Ticagrelor

Ticagrelor

Drugbox
IUPAC_name = (1S,2S,3R,5S)-3- [7- [(1R,2S)-2-(3,4-Difluorophenyl)cyclopropylamino] -5-(propylthio)-3H- [1,2,3] triazolo [4,5-d] pyrimidin-3-yl] -5-(2-hydroxyethoxy)cyclopentane-1,2-diol


CAS_number = 274693-27-5
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chemical_formula =
C=23 | H=28 | F=2 | N=6 | O=4 | S=1
molecular_weight = 522.567 g/mol
smiles = Fc2ccc(cc2F)C3CC3Nc5nc(SCCC)nc4c5nnn4C1CC(C(O)C1O)OCCO
bioavailability =
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routes_of_administration = oral

Ticagrelor (AZD6140) is a platelet aggregation inhibitor produced by AstraZeneca. as of|February 2008, a clinical trial clinical trial (PLATO: Platelet inhibition and patient outcomes) is comparing a combination of ticagrelor plus aspirin to clopidogrel plus aspirin for the prevention of thromboembolism.

Method of action

Like clopidogrel and ticlopidine, ticagrelor blocks ADP receptors of subtype P2Y12. In contrast to the other antiplatelet drugs, it blocks the receptor reversibly. Moreover, does not need hepatic activation, which could reduce the risk of drug interactions.

References

* cite journal
author = H. Spreitzer
date = February 4, 2008
title = Neue Wirkstoffe - AZD6140
journal = Österreichische Apothekerzeitung
issue = 3/2008
pages = 135
language = German
* cite journal
author = Owen, RT, Serradell, N, Bolos, J
title = AZD6140
journal = Drugs of the Future
year = 2007
volume = 32
issue = 10
pages = 845-853


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