Dermatan sulfate

Dermatan sulfate: Dermatan sulfate

Clinical data

AHFS/Drugs.com International Drug Names

Pregnancy cat. ?

Legal status ?

Identifiers

CAS number 24967-94-0

ATC code B01AX04

ChemSpider 30361^Y

Chemical data

Formula ?

SMILES eMolecules & PubChem

InChI

InChI=1S/C14H23NO15S/c1-3(17)15-5-10(9(30-31(24,25)26)4(2-16)27-13(5)23)28-14-8(20)6(18)7(19)11(29-14)12(21)22/h4-11,13-14,16,18-20,23H,2H2,1H3,(H,15,17)(H,21,22)(H,24,25,26)/p-2/t4-,5-,6+,7+,8-,9+,10-,11-,13-,14-/m1/s1^Y
Key:AVJBPWGFOQAPRH-FWMKGIEWSA-L^Y

Y(what is this?) sulfate (verify)

Dermatan sulfate is a glycosaminoglycan (formerly called a mucopolysaccharide) found mostly in skin, but also in blood vessels, heart valves, tendons, and lungs.

It is also referred to as chondroitin sulfate B, ^[1] although it is no longer classified as a form of chondroitin sulfate by most sources.

Contents

1 Function

2 Pathology

3 See also

4 External links

5 References

Function

Dermatan sulfate may have roles in coagulation, cardiovascular disease, carcinogenesis, infection, wound repair, and fibrosis.^[2]

Pathology

Dermatan sulfate accumulates abnormally in several of the mucopolysaccharidosis disorders.

An excess of Dermatan Sulfate in the Mitral Valve is characteristic of myxomatous degeneration of the leaflets leading to redundancy of valve tissue and ultimately, Mitral Valve Prolapse (into the Left atrium) and insufficiency. This chronic prolapse occurs mainly in women over the age of 60, and can predispose the patient to mitral annular calcification. Mitral valve insufficiency can lead to eccentric (volume dependent or dilated) hypertrophy and eventually Left Heart failure if untreated.

See also

iduronic acid

External links

MeSH Dermatan+sulfate

References

^ Trowbridge, JM; Gallo, RL (September 2002). "Dermatan sulfate: new functions from an old glycosaminoglycan". Glycobiology 12 (9): 117R–25R. doi:10.1093/glycob/cwf066. PMID 12213784.

^ Janet M. Trowbridge and Richard L. Gallo (2002). "Dermatan sulfate: new functions from an old glycosaminoglycan". pp. 117R-125R. doi:10.1093/glycob/cwf066. http://glycob.oxfordjournals.org/content/12/9/117R.short.

v · d · eAntithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)

Antiplatelet drugs

Glycoprotein IIb/IIIa inhibitors

Abciximab • Eptifibatide • Tirofiban

ADP receptor/P2Y₁₂ inhibitors

thienopyridines (Clopidogrel, Prasugrel, Ticlopidine) • nucleotide/nucleoside analogs (Cangrelor, Elinogrel, Ticagrelor)

Prostaglandin analogue (PGI2)

Beraprost • Prostacyclin • Iloprost • Treprostinil

COX inhibitors

Acetylsalicylic acid/Aspirin^# • Aloxiprin • Carbasalate calcium • Indobufen • Triflusal

Thromboxane inhibitors

thromboxane synthase inhibitors (Dipyridamole, Picotamide) • receptor antagonist (Terutroban^†)

Phosphodiesterase inhibitors

Cilostazol • Dipyridamole • Triflusal

Other

Cloricromen • Ditazole

Anticoagulants

Vitamin K antagonists
(inhibit II, VII, IX, X)

coumarins: Acenocoumarol • Coumatetralyl • Dicoumarol • Ethyl biscoumacetate • Phenprocoumon • Warfarin^#

1,3-Indandiones: Clorindione • Diphenadione • Phenindione
other: Tioclomarol

Factor Xa inhibitors
(with some II inhibition)

Heparin group/
glycosaminoglycans/
(bind antithrombin)

low-molecular-weight heparin (Bemiparin, Certoparin, Dalteparin, Enoxaparin, Nadroparin, Parnaparin, Reviparin, Tinzaparin)

oligosaccharides (Fondaparinux, Idraparinux)
heparinoid (Danaparoid, Sulodexide, Dermatan sulfate)

Direct Xa inhibitors

xabans (Apixaban, Betrixaban, Edoxaban, Otamixaban, Rivaroxaban)

Direct thrombin (II) inhibitors

bivalent: Hirudin (Bivalirudin, Lepirudin, Desirudin)
univalent: Argatroban • Dabigatran • Melagatran^‡ • Ximelagatran^‡

Other

REG1 • Defibrotide • Ramatroban • Antithrombin III • Protein C (Drotrecogin alfa)

Thrombolytic drugs/
fibrinolytics

plasminogen activators: r-tPA (Alteplase, Reteplase, Tenecteplase) • UPA (Urokinase, Saruplase) • Streptokinase^# • Anistreplase • Monteplase

other serine endopeptidases: Ancrod • Fibrinolysin
Brinase

Non-medicinal
Citrate • EDTA • Oxalate

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: MYL

cell/phys (coag, heme, immu, gran), csfs

rbmg/mogr/tumr/hist, sysi/epon, btst

drug (B1/2/3+5+6), btst, trns

v · Polysaccharides: glycosaminoglycans

Unsulfated, extracellular
Hyaluronan

Sulfated, extracellular
Chondroitin (Chondroitin sulfate, Dermatan sulfate) · Heparan sulfate · Keratan sulfate

Sulfated, intracellular
Heparin

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

Categories:
Glycosaminoglycans
Blood and blood forming organ drug stubs
Biochemistry stubs

Dermatan sulfate


Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	24967-94-0
ATC code	B01AX04
ChemSpider	30361^Y
Chemical data
Formula	?
SMILES	eMolecules & PubChem
InChI InChI=1S/C14H23NO15S/c1-3(17)15-5-10(9(30-31(24,25)26)4(2-16)27-13(5)23)28-14-8(20)6(18)7(19)11(29-14)12(21)22/h4-11,13-14,16,18-20,23H,2H2,1H3,(H,15,17)(H,21,22)(H,24,25,26)/p-2/t4-,5-,6+,7+,8-,9+,10-,11-,13-,14-/m1/s1^Y Key:AVJBPWGFOQAPRH-FWMKGIEWSA-L^Y
Y(what is this?) sulfate (verify)

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Look at other dictionaries:

dermatan sulfate — der·ma·tan sul·fate (dur″mə tan) a glycosaminoglycan found mostly in the skin but also in blood vessels, tendons, heart valves, and pulmonary connective tissues. It consists of repeating disaccharide units in specific linkage, each… … Medical dictionary
sulfate — A salt or ester of sulfuric acid. acid s. SYN: bisulfate. active s. SYN: adenosine 3′ phosphate 5′ phosphosulfate. s. adenylyltransferase an enzyme that catalyzes a step in the pathway for the synthesis of active s.; the enzyme reacts ATP wit … Medical dictionary
Chondroitin sulfate — Chemical structure of one unit in a chondroitin sulfate chain. Chondroitin 4 sulfate: R1 = H; R2 = SO3H; R3 = H. Chondroitin 6 sulfate: R1 = SO3H; R2, R3 = H … Wikipedia
Heparan sulfate — (HS) is a linear polysaccharide found in all animal tissues. It occurs as a proteoglycan (PG) in which two or three HS chains are attached in close proximity to cell surface or extracellular matrix proteins. [cite book | title=Proteoglycans:… … Wikipedia
chondroitin sulfate — n any of several sulfated forms of chondroitin found in various tissues (as cartilage, adult bone, and tendons) * * * chon·dro·i·tin sul·fate (kon droґĭ tin) 1. a glycosaminoglycan that predominates in the ground substance of cartilage, bone … Medical dictionary
Chondroitin sulfate proteoglycan — Chondroitin sulfate proteoglycans (CSPGs) are proteoglycans[1] consisting of a core protein and chondroitin sulfate. They are structural components of a variety of human tissues, for example of cartilage. The following CSPGs have been identified … Wikipedia
Chondroitin-sulfate-ABC endolyase — Identifiers EC number 4.2.2.20 Databases IntEnz IntEnz view … Wikipedia
Chondroitin-sulfate-ABC exolyase — Identifiers EC number 4.2.2.21 Databases IntEnz IntEnz view … Wikipedia
DSE (gene) — Dermatan sulfate epimerase Identifiers Symbols DSE; DSEPI; SART2 External IDs OMIM … Wikipedia
CHST14 — Dermatan 4 sulfotransferase 1, also known as D4ST1, is a human gene.cite web | title = Entrez Gene: D4ST1 dermatan 4 sulfotransferase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=113189| accessdate = ] … Wikipedia

Academic Dictionaries and Encyclopedias

Dermatan sulfate

Contents

Function

Pathology

See also

External links

References

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Academic Dictionaries and Encyclopedias

Wikipedia

Dermatan sulfate

Contents

Function

Pathology

See also

External links

References

Look at other dictionaries:

Share the article and excerpts

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