IUPAC_name =

CAS_number = 9001-90-5
ATC_prefix =B01
ATC_suffix = AD05
ATC_supplemental =
molecular_weight = ~ 13,800 g/mol
bioavailability = virtually none
metabolism = local inactivation
elimination_half-life = almost completely inactivated after 24 hours
pregnancy_category = C
legal_status = Rx only (where available)
routes_of_administration = ointment for local application, in combination with desoxyribonuclease

Fibrinolysin is an enzyme derived from plasma of bovine origin or extracted from cultures of certain bacteria. It is used locally only and exclusively together with the enzyme desoxyribonuclease (extracted from bovine pancreas). Fibrinolysin and desoxyribonuclease both act as lytic enzymes. The combination is available as ointment containing 1 BU (Biological Unit) fibrinolysin and 666 BUs desoxyribonuclease per gram.

Fibrinolysin attacks and inactivates fibrin molecules occurring in undesirable exudates on the surface of the human body and on human mucosa, e.g., in superficial wounds and burns, while desoxyribonuclease targets and destroys (human) DNA. The combination of the two enzymes has a synergistic effect on necrotic but not on living tissue. According to the manufacturer the ointment provides enhanced wound cleaning and accelerates the healing process.

Both enzymes are marginally resorbed into systemic circulation because of their very high molecular weight and their macromolecular structure.

The activity of both enzymes is almost completely exhausted after 24 hours. Usually, it is necessary to repeat the application (and renew the dressing) every 6 to 8 hours until healing becomes complete.

The ointment is marketed by Pfizer under the brand name Fibrolan in a variety of countries (e.g. Switzerland). It is currently not approved in the USA.

Where approved, Fibrolan has been licensed on the basis of claimed good therapeutical experience, but adequate and well controlled studies are still lacking.

In the past, combinations with the antibiotic chloramphenicol were available, but because chloramphenicol in any form of application has led to aplastic anemia and death, these were banned. Additionally, combinations with the antifibrinolytic agent tranexamic acid have been withdrawn from pharma markets.


Enzymatic wound cleaning to assist healing of minor burns, superficial wounds, ulcus cruris, and superficial hematoma.

Contraindications and Precautions

The ointment should not be used in patients with a known hypersensitivity to any ingredient. It should be used with caution in patients with hypersensitivity to bovine proteins in general and in pregnant women (category C), because no human data is available.


Infrequently, local reactions such as increased pain or a stitching/burning sensation are noticed. No systemic anticoagulant activity has been seen due to the exclusively local character of treatment.


Not known.

External References

* Swiss scientific product information
* (on chemical/biochemical properties)

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Look at other dictionaries:

  • fibrinolysin — [fī΄brə näl′ə sin] n. [ FIBRINO + LYSIN] any of various enzymes, esp. plasmin, capable of digesting fibrin in the bloodstream …   English World dictionary

  • fibrinolysin — plazminas statusas T sritis chemija apibrėžtis Kraujo fibriną skaidantis proteolitinis fermentas. atitikmenys: angl. fibrinolysin; plasmin rus. плазмин; фибринолизин ryšiai: sinonimas – fibrinolizinas …   Chemijos terminų aiškinamasis žodynas

  • fibrinolysin — noun Etymology: International Scientific Vocabulary Date: 1915 any of several proteolytic enzymes that promote the dissolution of blood clots; especially plasmin …   New Collegiate Dictionary

  • fibrinolysin — /fuy breuh nol euh sin/, n. Biochem. a proteolytic enzyme, formed in the blood from plasminogen, that causes the breakdown of the fibrin in blood clots. Also called plasmin. [1910 15; FIBRINO + LYSIN] * * * …   Universalium

  • fibrinolysin — SYN: plasmin. streptococcal f. SYN: streptokinase. * * * fi·bri·no·ly·sin .fī brən əl īs ən n any of several proteolytic enzymes that promote the dissolution of blood clots esp PLASMIN * * * n. see …   Medical dictionary

  • Fibrinolysin — Fi|brino|lysi̱n s; s, e: mit Hilfe aktivierender Enzyme gebildete fibrinauflösende Substanz im Körper …   Das Wörterbuch medizinischer Fachausdrücke

  • Fibrinolysin — Fi|bri|no|ly|sin das; s, e: mithilfe aktivierender ↑Enzyme gebildete Fibrin auflösende Substanz im Körper (Med.) …   Das große Fremdwörterbuch

  • fibrinolysin — n. enzyme which aids in the breakdown of fibrin …   English contemporary dictionary

  • fibrinolysin — fi·bri·nol·y·sin …   English syllables

  • fibrinolysin — n.; see plasmin …   The new mediacal dictionary

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