CYP4A11

Cytochrome P450, family 4, subfamily A, polypeptide 11, also known as CYP4A11, is a human gene.cite web | title = Entrez Gene: CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1579| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate.cite web | title = Entrez Gene: CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1579| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kawashima H, Kusunose E, Kubota I, "et al." |title=Purification and NH2-terminal amino acid sequences of human and rat kidney fatty acid omega-hydroxylases. |journal=Biochim. Biophys. Acta |volume=1123 |issue= 2 |pages= 156–62 |year= 1992 |pmid= 1739747 |doi=
*cite journal | author=Palmer CN, Richardson TH, Griffin KJ, "et al." |title=Characterization of a cDNA encoding a human kidney, cytochrome P-450 4A fatty acid omega-hydroxylase and the cognate enzyme expressed in Escherichia coli. |journal=Biochim. Biophys. Acta |volume=1172 |issue= 1-2 |pages= 161–6 |year= 1993 |pmid= 7679927 |doi=
*cite journal | author=Kawashima H, Kusunose E, Kikuta Y, "et al." |title=Purification and cDNA cloning of human liver CYP4A fatty acid omega-hydroxylase. |journal=J. Biochem. |volume=116 |issue= 1 |pages= 74–80 |year= 1995 |pmid= 7798189 |doi=
*cite journal | author=Imaoka S, Ogawa H, Kimura S, Gonzalez FJ |title=Complete cDNA sequence and cDNA-directed expression of CYP4A11, a fatty acid omega-hydroxylase expressed in human kidney. |journal=DNA Cell Biol. |volume=12 |issue= 10 |pages= 893–9 |year= 1994 |pmid= 8274222 |doi=
*cite journal | author=Bell DR, Plant NJ, Rider CG, "et al." |title=Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs. |journal=Biochem. J. |volume=294 ( Pt 1) |issue= |pages= 173–80 |year= 1993 |pmid= 8363569 |doi=
*cite journal | author=Powell PK, Wolf I, Lasker JM |title=Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes. |journal=Arch. Biochem. Biophys. |volume=335 |issue= 1 |pages= 219–26 |year= 1996 |pmid= 8914854 |doi= 10.1006/abbi.1996.0501
*cite journal | author=Powell PK, Wolf I, Jin R, Lasker JM |title=Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11. |journal=J. Pharmacol. Exp. Ther. |volume=285 |issue= 3 |pages= 1327–36 |year= 1998 |pmid= 9618440 |doi=
*cite journal | author=Chang YT, Loew GH |title=Homology modeling and substrate binding study of human CYP4A11 enzyme. |journal=Proteins |volume=34 |issue= 3 |pages= 403–15 |year= 1999 |pmid= 10024026 |doi=
*cite journal | author=Lasker JM, Chen WB, Wolf I, "et al." |title=Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11. |journal=J. Biol. Chem. |volume=275 |issue= 6 |pages= 4118–26 |year= 2000 |pmid= 10660572 |doi=
*cite journal | author=Kawashima H, Naganuma T, Kusunose E, "et al." |title=Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein. |journal=Arch. Biochem. Biophys. |volume=378 |issue= 2 |pages= 333–9 |year= 2000 |pmid= 10860550 |doi= 10.1006/abbi.2000.1831
*cite journal | author=Hoch U, Ortiz De Montellano PR |title=Covalently linked heme in cytochrome p4504a fatty acid hydroxylases. |journal=J. Biol. Chem. |volume=276 |issue= 14 |pages= 11339–46 |year= 2001 |pmid= 11139583 |doi= 10.1074/jbc.M009969200
*cite journal | author=Gonzalez MC, Marteau C, Franchi J, Migliore-Samour D |title=Cytochrome P450 4A11 expression in human keratinocytes: effects of ultraviolet irradiation. |journal=Br. J. Dermatol. |volume=145 |issue= 5 |pages= 749–57 |year= 2001 |pmid= 11736898 |doi=
*cite journal | author=LeBrun LA, Hoch U, Ortiz de Montellano PR |title=Autocatalytic mechanism and consequences of covalent heme attachment in the cytochrome P4504A family. |journal=J. Biol. Chem. |volume=277 |issue= 15 |pages= 12755–61 |year= 2002 |pmid= 11821421 |doi= 10.1074/jbc.M112155200
*cite journal | author=Savas U, Hsu MH, Johnson EF |title=Differential regulation of human CYP4A genes by peroxisome proliferators and dexamethasone. |journal=Arch. Biochem. Biophys. |volume=409 |issue= 1 |pages= 212–20 |year= 2003 |pmid= 12464261 |doi=
*cite journal | author=Bellamine A, Wang Y, Waterman MR, "et al." |title=Characterization of the CYP4A11 gene, a second CYP4A gene in humans. |journal=Arch. Biochem. Biophys. |volume=409 |issue= 1 |pages= 221–7 |year= 2003 |pmid= 12464262 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Jin P, Fu GK, Wilson AD, "et al." |title=PCR isolation and cloning of novel splice variant mRNAs from known drug target genes. |journal=Genomics |volume=83 |issue= 4 |pages= 566–71 |year= 2004 |pmid= 15028279 |doi= 10.1016/j.ygeno.2003.09.023
*cite journal | author=Ramírez J, Innocenti F, Schuetz EG, "et al." |title=CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes. |journal=Drug Metab. Dispos. |volume=32 |issue= 9 |pages= 930–6 |year= 2005 |pmid= 15319333 |doi=
*cite journal | author=Gainer JV, Bellamine A, Dawson EP, "et al." |title=Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. |journal=Circulation |volume=111 |issue= 1 |pages= 63–9 |year= 2005 |pmid= 15611369 |doi= 10.1161/01.CIR.0000151309.82473.59
*cite journal | author=Mayer B, Lieb W, Götz A, "et al." |title=Association of the T8590C polymorphism of CYP4A11 with hypertension in the MONICA Augsburg echocardiographic substudy. |journal=Hypertension |volume=46 |issue= 4 |pages= 766–71 |year= 2005 |pmid= 16144986 |doi= 10.1161/01.HYP.0000182658.04299.15

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