CYP26A1

Cytochrome P450, family 26, subfamily A, polypeptide 1, also known as CYP26A1, is a human gene.cite web | title = Entrez Gene: CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1592| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported.cite web | title = Entrez Gene: CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1592| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Duell EA, Kang S, Voorhees JJ |title=Retinoic acid isomers applied to human skin in vivo each induce a 4-hydroxylase that inactivates only trans retinoic acid. |journal=J. Invest. Dermatol. |volume=106 |issue= 2 |pages= 316–20 |year= 1996 |pmid= 8601734 |doi=
*cite journal | author=White JA, Beckett-Jones B, Guo YD, "et al." |title=cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450. |journal=J. Biol. Chem. |volume=272 |issue= 30 |pages= 18538–41 |year= 1997 |pmid= 9228017 |doi=
*cite journal | author=Ray WJ, Bain G, Yao M, Gottlieb DI |title=CYP26, a novel mammalian cytochrome P450, is induced by retinoic acid and defines a new family. |journal=J. Biol. Chem. |volume=272 |issue= 30 |pages= 18702–8 |year= 1997 |pmid= 9228041 |doi=
*cite journal | author=White JA, Beckett B, Scherer SW, "et al." |title=P450RAI (CYP26A1) maps to human chromosome 10q23-q24 and mouse chromosome 19C2-3. |journal=Genomics |volume=48 |issue= 2 |pages= 270–2 |year= 1998 |pmid= 9521883 |doi= 10.1006/geno.1997.5157
*cite journal | author=Sonneveld E, van den Brink CE, van der Leede BM, "et al." |title=Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells. |journal=Cell Growth Differ. |volume=9 |issue= 8 |pages= 629–37 |year= 1998 |pmid= 9716180 |doi=
*cite journal | author=Trofimova-Griffin ME, Juchau MR |title=Expression of cytochrome P450RAI (CYP26) in human fetal hepatic and cephalic tissues. |journal=Biochem. Biophys. Res. Commun. |volume=252 |issue= 2 |pages= 487–91 |year= 1998 |pmid= 9826557 |doi= 10.1006/bbrc.1998.9659
*cite journal | author=Popa C, Dicker AJ, Dahler AL, Saunders NA |title=Cytochrome P450, CYP26AI, is expressed at low levels in human epidermal keratinocytes and is not retinoic acid-inducible. |journal=Br. J. Dermatol. |volume=141 |issue= 3 |pages= 460–8 |year= 2000 |pmid= 10583049 |doi=
*cite journal | author=McSorley LC, Daly AK |title=Identification of human cytochrome P450 isoforms that contribute to all-trans-retinoic acid 4-hydroxylation. |journal=Biochem. Pharmacol. |volume=60 |issue= 4 |pages= 517–26 |year= 2000 |pmid= 10874126 |doi=
*cite journal | author=Loudig O, Babichuk C, White J, "et al." |title=Cytochrome P450RAI(CYP26) promoter: a distinct composite retinoic acid response element underlies the complex regulation of retinoic acid metabolism. |journal=Mol. Endocrinol. |volume=14 |issue= 9 |pages= 1483–97 |year= 2001 |pmid= 10976925 |doi=
*cite journal | author=Deng L, Shipley GL, Loose-Mitchell DS, "et al." |title=Coordinate regulation of the production and signaling of retinoic acid by estrogen in the human endometrium. |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 5 |pages= 2157–63 |year= 2003 |pmid= 12727970 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Won JY, Nam EC, Yoo SJ, "et al." |title=The effect of cellular retinoic acid binding protein-I expression on the CYP26-mediated catabolism of all-trans retinoic acid and cell proliferation in head and neck squamous cell carcinoma. |journal=Metab. Clin. Exp. |volume=53 |issue= 8 |pages= 1007–12 |year= 2004 |pmid= 15281009 |doi=
*cite journal | author=Loudig O, Maclean GA, Dore NL, "et al." |title=Transcriptional co-operativity between distant retinoic acid response elements in regulation of Cyp26A1 inducibility. |journal=Biochem. J. |volume=392 |issue= Pt 1 |pages= 241–8 |year= 2006 |pmid= 16053444 |doi= 10.1042/BJ20050874
*cite journal | author=Ozpolat B, Mehta K, Lopez-Berestein G |title=Regulation of a highly specific retinoic acid-4-hydroxylase (CYP26A1) enzyme and all-trans-retinoic acid metabolism in human intestinal, liver, endothelial, and acute promyelocytic leukemia cells. |journal=Leuk. Lymphoma |volume=46 |issue= 10 |pages= 1497–506 |year= 2005 |pmid= 16194896 |doi= 10.1080/10428190500174737
*cite journal | author=Heise R, Mey J, Neis MM, "et al." |title=Skin retinoid concentrations are modulated by CYP26AI expression restricted to basal keratinocytes in normal human skin and differentiated 3D skin models. |journal=J. Invest. Dermatol. |volume=126 |issue= 11 |pages= 2473–80 |year= 2007 |pmid= 16778795 |doi= 10.1038/sj.jid.5700432
*cite journal | author=Rat E, Billaut-Laden I, Allorge D, "et al." |title=Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida. |journal=Birth Defects Res. Part A Clin. Mol. Teratol. |volume=76 |issue= 6 |pages= 491–8 |year= 2006 |pmid= 16933217 |doi= 10.1002/bdra.20275
*cite journal | author=Gomaa MS, Yee SW, Milbourne CE, "et al." |title=Homology model of human retinoic acid metabolising enzyme cytochrome P450 26A1 (CYP26A1): active site architecture and ligand binding. |journal=J Enzyme Inhib Med Chem |volume=21 |issue= 4 |pages= 361–9 |year= 2007 |pmid= 17059167 |doi=
*cite journal | author=Quere R, Baudet A, Cassinat B, "et al." |title=Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. |journal=Blood |volume=109 |issue= 10 |pages= 4450–60 |year= 2007 |pmid= 17218384 |doi= 10.1182/blood-2006-10-051086
*cite journal | author=Lee SJ, Perera L, Coulter SJ, "et al." |title=The discovery of new coding alleles of human CYP26A1 that are potentially defective in the metabolism of all-trans retinoic acid and their assessment in a recombinant cDNA expression system. |journal=Pharmacogenet. Genomics |volume=17 |issue= 3 |pages= 169–80 |year= 2007 |pmid= 17460545 |doi= 10.1097/FPC.0b013e32801152d6

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