ALDH1A2

Aldehyde dehydrogenase 1 family, member A2, also known as ALDH1A2, is a human gene.cite web | title = Entrez Gene: ALDH1A2 aldehyde dehydrogenase 1 family, member A2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8854| accessdate = ]

PBB_Summary
section_title =
summary_text = This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Three transcript variants encoding distinct isoforms have been identified for this gene.cite web | title = Entrez Gene: ALDH1A2 aldehyde dehydrogenase 1 family, member A2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8854| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wang X, Penzes P, Napoli JL |title=Cloning of a cDNA encoding an aldehyde dehydrogenase and its expression in Escherichia coli. Recognition of retinal as substrate. |journal=J. Biol. Chem. |volume=271 |issue= 27 |pages= 16288–93 |year= 1996 |pmid= 8663198 |doi=
*cite journal | author=Zhao D, McCaffery P, Ivins KJ, "et al." |title=Molecular identification of a major retinoic-acid-synthesizing enzyme, a retinaldehyde-specific dehydrogenase. |journal=Eur. J. Biochem. |volume=240 |issue= 1 |pages= 15–22 |year= 1996 |pmid= 8797830 |doi=
*cite journal | author=Ono Y, Fukuhara N, Yoshie O |title=TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3. |journal=Mol. Cell. Biol. |volume=18 |issue= 12 |pages= 6939–50 |year= 1998 |pmid= 9819382 |doi=
*cite journal | author=Niederreither K, Subbarayan V, Dollé P, Chambon P |title=Embryonic retinoic acid synthesis is essential for early mouse post-implantation development. |journal=Nat. Genet. |volume=21 |issue= 4 |pages= 444–8 |year= 1999 |pmid= 10192400 |doi= 10.1038/7788
*cite journal | author=Niederreither K, Abu-Abed S, Schuhbaur B, "et al." |title=Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development. |journal=Nat. Genet. |volume=31 |issue= 1 |pages= 84–8 |year= 2002 |pmid= 11953746 |doi= 10.1038/ng876
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Anderson NL, Polanski M, Pieper R, "et al." |title=The human plasma proteome: a nonredundant list developed by combination of four separate sources. |journal=Mol. Cell Proteomics |volume=3 |issue= 4 |pages= 311–26 |year= 2004 |pmid= 14718574 |doi= 10.1074/mcp.M300127-MCP200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Deak KL, Dickerson ME, Linney E, "et al." |title=Analysis of ALDH1A2, CYP26A1, CYP26B1, CRABP1, and CRABP2 in human neural tube defects suggests a possible association with alleles in ALDH1A2. |journal=Birth Defects Res. Part A Clin. Mol. Teratol. |volume=73 |issue= 11 |pages= 868–75 |year= 2006 |pmid= 16237707 |doi= 10.1002/bdra.20183
*cite journal | author=Ribes V, Wang Z, Dollé P, Niederreither K |title=Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signaling. |journal=Development |volume=133 |issue= 2 |pages= 351–61 |year= 2006 |pmid= 16368932 |doi= 10.1242/dev.02204

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