AKAP4

A kinase (PRKA) anchor protein 4, also known as AKAP4, is a human gene.cite web | title = Entrez Gene: AKAP4 A kinase (PRKA) anchor protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8852| accessdate = ]

PBB_Summary
section_title =
summary_text = The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms.cite web | title = Entrez Gene: AKAP4 A kinase (PRKA) anchor protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8852| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lester LB, Scott JD |title=Anchoring and scaffold proteins for kinases and phosphatases. |journal=Recent Prog. Horm. Res. |volume=52 |issue= |pages= 409–29; discussion 429–30 |year= 1997 |pmid= 9238861 |doi=
*cite journal | author=Michel JJ, Scott JD |title=AKAP mediated signal transduction. |journal=Annu. Rev. Pharmacol. Toxicol. |volume=42 |issue= |pages= 235–57 |year= 2002 |pmid= 11807172 |doi= 10.1146/annurev.pharmtox.42.083101.135801
*cite journal | author=Mohapatra B, Verma S, Shankar S, Suri A |title=Molecular cloning of human testis mRNA specifically expressed in haploid germ cells, having structural homology with the A-kinase anchoring proteins. |journal=Biochem. Biophys. Res. Commun. |volume=244 |issue= 2 |pages= 540–5 |year= 1998 |pmid= 9514854 |doi= 10.1006/bbrc.1998.8079
*cite journal | author=Turner RM, Johnson LR, Haig-Ladewig L, "et al." |title=An X-linked gene encodes a major human sperm fibrous sheath protein, hAKAP82. Genomic organization, protein kinase A-RII binding, and distribution of the precursor in the sperm tail. |journal=J. Biol. Chem. |volume=273 |issue= 48 |pages= 32135–41 |year= 1998 |pmid= 9822690 |doi=
*cite journal | author=Miki K, Eddy EM |title=Identification of tethering domains for protein kinase A type Ialpha regulatory subunits on sperm fibrous sheath protein FSC1. |journal=J. Biol. Chem. |volume=273 |issue= 51 |pages= 34384–90 |year= 1999 |pmid= 9852104 |doi=
*cite journal | author=Turner RM, Foster JA, Gerton GL, "et al." |title=Molecular evaluation of two major human sperm fibrous sheath proteins, pro-hAKAP82 and hAKAP82, in stump tail sperm. |journal=Fertil. Steril. |volume=76 |issue= 2 |pages= 267–74 |year= 2001 |pmid= 11476771 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ficarro S, Chertihin O, Westbrook VA, "et al." |title=Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11579–89 |year= 2003 |pmid= 12509440 |doi= 10.1074/jbc.M202325200
*cite journal | author=Brown PR, Miki K, Harper DB, Eddy EM |title=A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum. |journal=Biol. Reprod. |volume=68 |issue= 6 |pages= 2241–8 |year= 2004 |pmid= 12606363 |doi= 10.1095/biolreprod.102.013466
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ross MT, Grafham DV, Coffey AJ, "et al." |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440
*cite journal | author=Lefièvre L, Chen Y, Conner SJ, "et al." |title=Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide? |journal=Proteomics |volume=7 |issue= 17 |pages= 3066–84 |year= 2007 |pmid= 17683036 |doi= 10.1002/pmic.200700254
*cite journal | author=Moretti E, Scapigliati G, Pascarelli NA, "et al." |title=Localization of AKAP4 and tubulin proteins in sperm with reduced motility. |journal=Asian J. Androl. |volume=9 |issue= 5 |pages= 641–9 |year= 2007 |pmid= 17712481 |doi= 10.1111/j.1745-7262.2007.267.x

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