- CYP3A
Cytochrome P450, family 3, subfamily A, also known as CYP3A, is a human
gene .cite web | title = Entrez Gene: CYP3A cytochrome P450, family 3, subfamily A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1574| accessdate = ]The CYP3A locus includes all the known members of the 3A subfamily of the
cytochrome P450 superfamily of genes. These genes encodemonooxygenase s which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The CYP3A cluster consists of four genes:
*CYP3A4
*CYP3A5 ,
*CYP3A7 , and
*CYP3A43 . The region also contains twopseudogene s:
* and
*, as well as several extra exons which may or may not be included in transcripts produced from this region. Previously another CYP3A member, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4.cite web | title = Entrez Gene: CYP3A cytochrome P450, family 3, subfamily A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1574| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129–65 |year= 1999 |pmid= 9890157 |doi=
*cite journal | author=Lamba JK, Lin YS, Schuetz EG, Thummel KE |title=Genetic contribution to variable human CYP3A-mediated metabolism. |journal=Adv. Drug Deliv. Rev. |volume=54 |issue= 10 |pages= 1271–94 |year= 2003 |pmid= 12406645 |doi=
*cite journal | author=Finta C, Zaphiropoulos PG |title=The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons. |journal=Gene |volume=260 |issue= 1-2 |pages= 13–23 |year= 2001 |pmid= 11137287 |doi=
*cite journal | author=Gellner K, Eiselt R, Hustert E, "et al." |title=Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene. |journal=Pharmacogenetics |volume=11 |issue= 2 |pages= 111–21 |year= 2001 |pmid= 11266076 |doi=
*cite journal | author=Miyazawa M, Shindo M, Shimada T |title=Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes. |journal=Xenobiotica |volume=31 |issue= 10 |pages= 713–23 |year= 2002 |pmid= 11695850 |doi=
*cite journal | author=Reid JM, Kuffel MJ, Ruben SL, "et al." |title=Rat and human liver cytochrome P-450 isoform metabolism of ecteinascidin 743 does not predict gender-dependent toxicity in humans. |journal=Clin. Cancer Res. |volume=8 |issue= 9 |pages= 2952–62 |year= 2002 |pmid= 12231541 |doi=
*cite journal | author=Martínez C, García-Martín E, Pizarro RM, "et al." |title=Expression of paclitaxel-inactivating CYP3A activity in human colorectal cancer: implications for drug therapy. |journal=Br. J. Cancer |volume=87 |issue= 6 |pages= 681–6 |year= 2002 |pmid= 12237780 |doi= 10.1038/sj.bjc.6600494
*cite journal | author=Dowling TC, Briglia AE, Fink JC, "et al." |title=Characterization of hepatic cytochrome p4503A activity in patients with end-stage renal disease. |journal=Clin. Pharmacol. Ther. |volume=73 |issue= 5 |pages= 427–34 |year= 2003 |pmid= 12732843 |doi=
*cite journal | author=Sunman JA, Hawke RL, LeCluyse EL, Kashuba AD |title=Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes. |journal=Drug Metab. Dispos. |volume=32 |issue= 3 |pages= 359–63 |year= 2004 |pmid= 14977871 |doi= 10.1124/dmd.32.3.359
*cite journal | author=Somogyi AA, Menelaou A, Fullston SV |title=CYP3A4 mediates dextropropoxyphene N-demethylation to nordextropropoxyphene: human in vitro and in vivo studies and lack of CYP2D6 involvement. |journal=Xenobiotica |volume=34 |issue= 10 |pages= 875–87 |year= 2005 |pmid= 15764408 |doi= 10.1080/00498250400008371
*cite journal | author=Thompson EE, Kuttab-Boulos H, Yang L, "et al." |title=Sequence diversity and haplotype structure at the human CYP3A cluster. |journal=Pharmacogenomics J. |volume=6 |issue= 2 |pages= 105–14 |year= 2006 |pmid= 16314882 |doi= 10.1038/sj.tpj.6500347
*cite journal | author=Bochud M, Eap CB, Elston RC, "et al." |title=Association of CYP3A5 genotypes with blood pressure and renal function in African families. |journal=J. Hypertens. |volume=24 |issue= 5 |pages= 923–9 |year= 2006 |pmid= 16612255 |doi= 10.1097/01.hjh.0000222763.84605.4a
*cite journal | author=Cheung CY, Op den Buijsch RA, Wong KM, "et al." |title=Influence of different allelic variants of the CYP3A and ABCB1 genes on the tacrolimus pharmacokinetic profile of Chinese renal transplant recipients. |journal=Pharmacogenomics |volume=7 |issue= 4 |pages= 563–74 |year= 2006 |pmid= 16753004 |doi= 10.2217/14622416.7.4.563
*cite journal | author=Rais N, Chawla YK, Kohli KK |title=CYP3A phenotypes and genotypes in North Indians. |journal=Eur. J. Clin. Pharmacol. |volume=62 |issue= 6 |pages= 417–22 |year= 2007 |pmid= 16758258 |doi= 10.1007/s00228-006-0105-3
*cite journal | author=Kirby B, Kharasch ED, Thummel KT, "et al." |title=Simultaneous measurement of in vivo P-glycoprotein and cytochrome P450 3A activities. |journal=Journal of clinical pharmacology |volume=46 |issue= 11 |pages= 1313–9 |year= 2007 |pmid= 17050796 |doi= 10.1177/0091270006292625
*cite journal | author=He P, Court MH, Greenblatt DJ, von Moltke LL |title=Human pregnane X receptor: genetic polymorphisms, alternative mRNA splice variants, and cytochrome P450 3A metabolic activity. |journal=Journal of clinical pharmacology |volume=46 |issue= 11 |pages= 1356–69 |year= 2007 |pmid= 17050801 |doi= 10.1177/0091270006292125
*cite journal | author=Watanabe A, Nakamura K, Okudaira N, "et al." |title=Risk assessment for drug-drug interaction caused by metabolism-based inhibition of CYP3A using automated in vitro assay systems and its application in the early drug discovery process. |journal=Drug Metab. Dispos. |volume=35 |issue= 7 |pages= 1232–8 |year= 2007 |pmid= 17392390 |doi= 10.1124/dmd.107.015016
*cite journal | author=Kharasch ED, Walker A, Isoherranen N, "et al." |title=Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam. |journal=Clin. Pharmacol. Ther. |volume=82 |issue= 4 |pages= 410–26 |year= 2007 |pmid= 17554244 |doi= 10.1038/sj.clpt.6100237PBB_Controls
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