- FMO4
Flavin containing monooxygenase 4, also known as FMO4, is a human
gene .cite web | title = Entrez Gene: FMO4 flavin containing monooxygenase 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2329| accessdate = ]PBB_Summary
section_title =
summary_text = Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.cite web | title = Entrez Gene: FMO4 flavin containing monooxygenase 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2329| accessdate = ]References
Further reading
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citations =
*cite journal | author=Hines RN, Cashman JR, Philpot RM, "et al." |title=The mammalian flavin-containing monooxygenases: molecular characterization and regulation of expression. |journal=Toxicol. Appl. Pharmacol. |volume=125 |issue= 1 |pages= 1–6 |year= 1994 |pmid= 8128486 |doi= 10.1006/taap.1994.1042
*cite journal | author=Dolphin CT, Shephard EA, Povey S, "et al." |title=Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family. |journal=Biochem. J. |volume=287 ( Pt 1) |issue= |pages= 261–7 |year= 1992 |pmid= 1417778 |doi=
*cite journal | author=Phillips IR, Dolphin CT, Clair P, "et al." |title=The molecular biology of the flavin-containing monooxygenases of man. |journal=Chem. Biol. Interact. |volume=96 |issue= 1 |pages= 17–32 |year= 1995 |pmid= 7720101 |doi=
*cite journal | author=Lawton MP, Cashman JR, Cresteil T, "et al." |title=A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities. |journal=Arch. Biochem. Biophys. |volume=308 |issue= 1 |pages= 254–7 |year= 1994 |pmid= 8311461 |doi=
*cite journal | author=Itagaki K, Carver GT, Philpot RM |title=Expression and characterization of a modified flavin-containing monooxygenase 4 from humans. |journal=J. Biol. Chem. |volume=271 |issue= 33 |pages= 20102–7 |year= 1996 |pmid= 8702731 |doi=
*cite journal | author=Janmohamed A, Dolphin CT, Phillips IR, Shephard EA |title=Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450. |journal=Biochem. Pharmacol. |volume=62 |issue= 6 |pages= 777–86 |year= 2001 |pmid= 11551524 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Furnes B, Feng J, Sommer SS, Schlenk D |title=Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans. |journal=Drug Metab. Dispos. |volume=31 |issue= 2 |pages= 187–93 |year= 2003 |pmid= 12527699 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727PBB_Controls
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