Aldosterone synthase

Aldosterone synthase

Aldosterone synthase (or 18-hydroxylase) is a steroid hydroxylase cytochrome P450 oxidase enzyme involved in the generation of aldosterone.

section_title =
summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. [cite web | title = Entrez Gene: CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2| url =| accessdate = ]

It converts 11-deoxycorticosterone to corticosterone, to 18-hydroxycorticosterone, and finally to aldosterone:

It is found in the zona glomerulosa.



Further reading

citations =
*cite journal | author=Helmberg A |title=Twin genes and endocrine disease: CYP21 and CYP11B genes. |journal=Acta Endocrinol. |volume=129 |issue= 2 |pages= 97–108 |year= 1993 |pmid= 8372604 |doi=
*cite journal | author=Slight SH, Joseph J, Ganjam VK, Weber KT |title=Extra-adrenal mineralocorticoids and cardiovascular tissue. |journal=J. Mol. Cell. Cardiol. |volume=31 |issue= 6 |pages= 1175–84 |year= 1999 |pmid= 10371693 |doi= 10.1006/jmcc.1999.0963
*cite journal | author=Stowasser M, Gunasekera TG, Gordon RD |title=Familial varieties of primary aldosteronism. |journal=Clin. Exp. Pharmacol. Physiol. |volume=28 |issue= 12 |pages= 1087–90 |year= 2002 |pmid= 11903322 |doi=
*cite journal | author=Padmanabhan N, Padmanabhan S, Connell JM |title=Genetic basis of cardiovascular disease--the renin-angiotensin-aldosterone system as a paradigm. |journal=Journal of the renin-angiotensin-aldosterone system : JRAAS |volume=1 |issue= 4 |pages= 316–24 |year= 2002 |pmid= 11967817 |doi= 10.3317/jraas.2000.060
*cite journal | author=Lifton RP, Dluhy RG, Powers M, "et al." |title=Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase. |journal=Nat. Genet. |volume=2 |issue= 1 |pages= 66–74 |year= 1993 |pmid= 1303253 |doi= 10.1038/ng0992-66
*cite journal | author=Mitsuuchi Y, Kawamoto T, Naiki Y, "et al." |title=Congenitally defective aldosterone biosynthesis in humans: the involvement of point mutations of the P-450C18 gene (CYP11B2) in CMO II deficient patients. |journal=Biochem. Biophys. Res. Commun. |volume=182 |issue= 2 |pages= 974–9 |year= 1992 |pmid= 1346492 |doi=
*cite journal | author=Pascoe L, Curnow KM, Slutsker L, "et al." |title=Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 17 |pages= 8327–31 |year= 1992 |pmid= 1518866 |doi=
*cite journal | author=Pascoe L, Curnow KM, Slutsker L, "et al." |title=Mutations in the human CYP11B2 (aldosterone synthase) gene causing corticosterone methyloxidase II deficiency. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 11 |pages= 4996–5000 |year= 1992 |pmid= 1594605 |doi=
*cite journal | author=Kawamoto T, Mitsuuchi Y, Toda K, "et al." |title=Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 4 |pages= 1458–62 |year= 1992 |pmid= 1741400 |doi=
*cite journal | author=Curnow KM, Tusie-Luna MT, Pascoe L, "et al." |title=The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex. |journal=Mol. Endocrinol. |volume=5 |issue= 10 |pages= 1513–22 |year= 1992 |pmid= 1775135 |doi=
*cite journal | author=Kawainoto T, Mitsuuchi Y, Ohnishi T, "et al." |title=Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism. |journal=Biochem. Biophys. Res. Commun. |volume=173 |issue= 1 |pages= 309–16 |year= 1991 |pmid= 2256920 |doi=
*cite journal | author=Mornet E, Dupont J, Vitek A, White PC |title=Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta). |journal=J. Biol. Chem. |volume=264 |issue= 35 |pages= 20961–7 |year= 1990 |pmid= 2592361 |doi=
*cite journal | author=Martsev SP, Chashchin VL, Akhrem AA |title= [Reconstruction and study of a multi-enzyme system by 11 beta-hydroxylase steroids] |journal=Biokhimiia |volume=50 |issue= 2 |pages= 243–57 |year= 1985 |pmid= 3872685 |doi=
*cite journal | author=Shizuta Y, Kawamoto T, Mitsuuchi Y, "et al." |title=Inborn errors of aldosterone biosynthesis in humans. |journal=Steroids |volume=60 |issue= 1 |pages= 15–21 |year= 1995 |pmid= 7792802 |doi=
*cite journal | author=Mitsuuchi Y, Kawamoto T, Miyahara K, "et al." |title=Congenitally defective aldosterone biosynthesis in humans: inactivation of the P-450C18 gene (CYP11B2) due to nucleotide deletion in CMO I deficient patients. |journal=Biochem. Biophys. Res. Commun. |volume=190 |issue= 3 |pages= 864–9 |year= 1993 |pmid= 8439335 |doi=
*cite journal | author=Fardella CE, Rodriguez H, Montero J, "et al." |title=Genetic variation in P450c11AS in Chilean patients with low renin hypertension. |journal=J. Clin. Endocrinol. Metab. |volume=81 |issue= 12 |pages= 4347–51 |year= 1997 |pmid= 8954040 |doi=
*cite journal | author=Nomoto S, Massa G, Mitani F, "et al." |title=CMO I deficiency caused by a point mutation in exon 8 of the human CYP11B2 gene encoding steroid 18-hydroxylase (P450C18). |journal=Biochem. Biophys. Res. Commun. |volume=234 |issue= 2 |pages= 382–5 |year= 1997 |pmid= 9177280 |doi=
*cite journal | author=Peter M, Fawaz L, Drop SL, "et al." |title=Hereditary defect in biosynthesis of aldosterone: aldosterone synthase deficiency 1964-1997. |journal=J. Clin. Endocrinol. Metab. |volume=82 |issue= 11 |pages= 3525–8 |year= 1997 |pmid= 9360501 |doi=
*cite journal | author=Taymans SE, Pack S, Pak E, "et al." |title=Human CYP11B2 (aldosterone synthase) maps to chromosome 8q24.3. |journal=J. Clin. Endocrinol. Metab. |volume=83 |issue= 3 |pages= 1033–6 |year= 1998 |pmid= 9506770 |doi=

External links


update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes

Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • aldosterone synthase deficiency — al·dos·ter·one syn·thase de·fi·cien·cy (al dosґtər ōn sinґthās) a disorder of steroidogenesis caused by mutations in the CYP11B2 gene (locus: 8q21) that result in a deficiency of aldosterone synthase activity, impairing the… …   Medical dictionary

  • aldosterone synthase — al·dos·ter·one syn·thase (al dosґtər ōn sinґthās) an isozyme of steroid 11β monooxygenase that catalyzes the last three steps (11 hydroxylation, 18 hydroxylation, and 18 oxidation) in the synthesis of aldosterone from… …   Medical dictionary

  • Aldosterone — Aldostérone Aldostérone Molécule d aldostérone Général No CAS …   Wikipédia en Français

  • Aldostérone — Molécule d aldostérone Général No CAS …   Wikipédia en Français

  • Aldosterone — Chembox new ImageFile = Aldosterone 2D skeletal.svg ImageSize = IUPACName = 11β,21 dihydroxy 3,20 dioxopregn 4 en 18 al OtherNames = Section1 = Chembox Identifiers CASNo = 52 39 1 PubChem = 5839 SMILES = C [C@] 12CCC(=O)C=C1CC [C@@H] 3 [C@@H] 2… …   Wikipedia

  • ATP synthase — Molecular model of ATP synthase by X ray diffraction method ATP synthase (EC is an important enzyme that provides energy for the cell to use through the synthesis of adenosine triphosphate (ATP). ATP is the most commonly used energy… …   Wikipedia

  • Citrate synthase — Identifiers Symbol CS Entrez 1431 HUGO …   Wikipedia

  • N-Acetylglutamate synthase — Identifiers Symbol NAGS Entrez 162417 HUGO …   Wikipedia

  • 52-39-1 — Aldostérone Aldostérone Molécule d aldostérone Général No CAS …   Wikipédia en Français

  • Steroid 11-beta-hydroxylase — Cytochrome P450, family 11, subfamily B, polypeptide 1 Identifiers Symbols CYP11B1; CPN1; CYP11B; DKFZp686B05283; FHI; FLJ36771; P450C11 External IDs …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”