- SULT1A1
Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1, also known as SULT1A1, is a human
gene .cite web | title = Entrez Gene: SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6817| accessdate = ]PBB_Summary
section_title =
summary_text = Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene.cite web | title = Entrez Gene: SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6817| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Weinshilboum RM, Otterness DM, Aksoy IA, "et al." |title=Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes. |journal=FASEB J. |volume=11 |issue= 1 |pages= 3–14 |year= 1997 |pmid= 9034160 |doi=
*cite journal | author=Windmill KF, Christiansen A, Teusner JT, "et al." |title=Localisation of aryl sulfotransferase expression in human tissues using hybridisation histochemistry and immunohistochemistry. |journal=Chem. Biol. Interact. |volume=109 |issue= 1-3 |pages= 341–6 |year= 1998 |pmid= 9566757 |doi=
*cite journal | author=Glatt H, Engelke CE, Pabel U, "et al." |title=Sulfotransferases: genetics and role in toxicology. |journal=Toxicol. Lett. |volume=112-113 |issue= |pages= 341–8 |year= 2000 |pmid= 10720750 |doi=
*cite journal | author=Glatt H |title=Sulfotransferases in the bioactivation of xenobiotics. |journal=Chem. Biol. Interact. |volume=129 |issue= 1-2 |pages= 141–70 |year= 2001 |pmid= 11154739 |doi=
*cite journal | author=Glatt H, Boeing H, Engelke CE, "et al." |title=Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects. |journal=Mutat. Res. |volume=482 |issue= 1-2 |pages= 27–40 |year= 2001 |pmid= 11535246 |doi=
*cite journal | author=Ozawa S, Nagata K, Shimada M, "et al." |title=Primary structures and properties of two related forms of aryl sulfotransferases in human liver. |journal=Pharmacogenetics |volume=5 Spec No |issue= |pages= S135–40 |year= 1995 |pmid= 7581483 |doi=
*cite journal | author=Jones AL, Hagen M, Coughtrie MW, "et al." |title=Human platelet phenolsulfotransferases: cDNA cloning, stable expression in V79 cells and identification of a novel allelic variant of the phenol-sulfating form. |journal=Biochem. Biophys. Res. Commun. |volume=208 |issue= 2 |pages= 855–62 |year= 1995 |pmid= 7695643 |doi= 10.1006/bbrc.1995.1414
*cite journal | author=Hwang SR, Kohn AB, Hook VY |title=Molecular cloning of an isoform of phenol sulfotransferase from human brain hippocampus. |journal=Biochem. Biophys. Res. Commun. |volume=207 |issue= 2 |pages= 701–7 |year= 1995 |pmid= 7864863 |doi=
*cite journal | author=Yamazoe Y, Nagata K, Ozawa S, Kato R |title=Structural similarity and diversity of sulfotransferases. |journal=Chem. Biol. Interact. |volume=92 |issue= 1-3 |pages= 107–17 |year= 1994 |pmid= 8033246 |doi=
*cite journal | author=Falany CN, Zhuang W, Falany JL |title=Characterization of expressed human phenol-sulfating phenol sulfotransferase: effect of mutating cys70 on activity and thermostability. |journal=Chem. Biol. Interact. |volume=92 |issue= 1-3 |pages= 57–66 |year= 1994 |pmid= 8033270 |doi=
*cite journal | author=Veronese ME, Burgess W, Zhu X, McManus ME |title=Functional characterization of two human sulphotransferase cDNAs that encode monoamine- and phenol-sulphating forms of phenol sulphotransferase: substrate kinetics, thermal-stability and inhibitor-sensitivity studies. |journal=Biochem. J. |volume=302 ( Pt 2) |issue= |pages= 497–502 |year= 1994 |pmid= 8093002 |doi=
*cite journal | author=Dooley TP, Obermoeller RD, Leiter EH, "et al." |title=Mapping of the phenol sulfotransferase gene (STP) to human chromosome 16p12.1-p11.2 and to mouse chromosome 7. |journal=Genomics |volume=18 |issue= 2 |pages= 440–3 |year= 1994 |pmid= 8288252 |doi= 10.1006/geno.1993.1494
*cite journal | author=Zhu X, Veronese ME, Bernard CC, "et al." |title=Identification of two human brain aryl sulfotransferase cDNAs. |journal=Biochem. Biophys. Res. Commun. |volume=195 |issue= 1 |pages= 120–7 |year= 1993 |pmid= 8363592 |doi=
*cite journal | author=Wilborn TW, Comer KA, Dooley TP, "et al." |title=Sequence analysis and expression of the cDNA for the phenol-sulfating form of human liver phenol sulfotransferase. |journal=Mol. Pharmacol. |volume=43 |issue= 1 |pages= 70–7 |year= 1993 |pmid= 8423770 |doi=
*cite journal | author=Zhu X, Veronese ME, Sansom LN, McManus ME |title=Molecular characterisation of a human aryl sulfotransferase cDNA. |journal=Biochem. Biophys. Res. Commun. |volume=192 |issue= 2 |pages= 671–6 |year= 1993 |pmid= 8484775 |doi=
*cite journal | author=Her C, Raftogianis R, Weinshilboum RM |title=Human phenol sulfotransferase STP2 gene: molecular cloning, structural characterization, and chromosomal localization. |journal=Genomics |volume=33 |issue= 3 |pages= 409–20 |year= 1996 |pmid= 8661000 |doi= 10.1006/geno.1996.0216
*cite journal | author=Dooley TP, Huang Z |title=Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16. |journal=Biochem. Biophys. Res. Commun. |volume=228 |issue= 1 |pages= 134–40 |year= 1996 |pmid= 8912648 |doi= 10.1006/bbrc.1996.1628
*cite journal | author=Bernier F, Soucy P, Luu-The V |title=Human phenol sulfotransferase gene contains two alternative promoters: Structure and expression of the gene. |journal=DNA Cell Biol. |volume=15 |issue= 5 |pages= 367–75 |year= 1996 |pmid= 8924211 |doi=
*cite journal | author=Raftogianis RB, Her C, Weinshilboum RM |title=Human phenol sulfotransferase pharmacogenetics: STP1 gene cloning and structural characterization. |journal=Pharmacogenetics |volume=6 |issue= 6 |pages= 473–87 |year= 1997 |pmid= 9014197 |doi=PBB_Controls
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