Uracil-DNA glycosylase

Uracil-DNA glycosylase

Uracil-DNA glycosylase, also known as UNG, is a human gene.cite web | title = Entrez Gene: UNG uracil-DNA glycosylase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7374| accessdate = ]

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summary_text = This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2.cite web | title = Entrez Gene: UNG uracil-DNA glycosylase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7374| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Caradonna S, Muller-Weeks S |title=The nature of enzymes involved in uracil-DNA repair: isoform characteristics of proteins responsible for nuclear and mitochondrial genomic integrity. |journal=Curr. Protein Pept. Sci. |volume=2 |issue= 4 |pages= 335–47 |year= 2002 |pmid= 12369930 |doi=
*cite journal | author=Kino T, Pavlakis GN |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 193–205 |year= 2004 |pmid= 15142377 |doi= 10.1089/104454904773819789
*cite journal | author=Van Maele B, Debyser Z |title=HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins. |journal=AIDS reviews |volume=7 |issue= 1 |pages= 26–43 |year= 2005 |pmid= 15875659 |doi=
*cite journal | author=Slupphaug G, Olsen LC, Helland D, "et al." |title=Cell cycle regulation and in vitro hybrid arrest analysis of the major human uracil-DNA glycosylase. |journal=Nucleic Acids Res. |volume=19 |issue= 19 |pages= 5131–7 |year= 1991 |pmid= 1923798 |doi=
*cite journal | author=Muller SJ, Caradonna S |title=Isolation and characterization of a human cDNA encoding uracil-DNA glycosylase. |journal=Biochim. Biophys. Acta |volume=1088 |issue= 2 |pages= 197–207 |year= 1991 |pmid= 2001396 |doi=
*cite journal | author=Olsen LC, Aasland R, Wittwer CU, "et al." |title=Molecular cloning of human uracil-DNA glycosylase, a highly conserved DNA repair enzyme. |journal=EMBO J. |volume=8 |issue= 10 |pages= 3121–5 |year= 1990 |pmid= 2555154 |doi=
*cite journal | author=Nagelhus TA, Slupphaug G, Lindmo T, Krokan HE |title=Cell cycle regulation and subcellular localization of the major human uracil-DNA glycosylase. |journal=Exp. Cell Res. |volume=220 |issue= 2 |pages= 292–7 |year= 1995 |pmid= 7556436 |doi= 10.1006/excr.1995.1318
*cite journal | author=Mol CD, Arvai AS, Sanderson RJ, "et al." |title=Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA. |journal=Cell |volume=82 |issue= 5 |pages= 701–8 |year= 1995 |pmid= 7671300 |doi=
*cite journal | author=Mol CD, Arvai AS, Slupphaug G, "et al." |title=Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis. |journal=Cell |volume=80 |issue= 6 |pages= 869–78 |year= 1995 |pmid= 7697717 |doi=
*cite journal | author=Haug T, Skorpen F, Lund H, Krokan HE |title=Structure of the gene for human uracil-DNA glycosylase and analysis of the promoter function. |journal=FEBS Lett. |volume=353 |issue= 2 |pages= 180–4 |year= 1994 |pmid= 7926048 |doi=
*cite journal | author=Slupphaug G, Markussen FH, Olsen LC, "et al." |title=Nuclear and mitochondrial forms of human uracil-DNA glycosylase are encoded by the same gene. |journal=Nucleic Acids Res. |volume=21 |issue= 11 |pages= 2579–84 |year= 1993 |pmid= 8332455 |doi=
*cite journal | author=Bouhamdan M, Benichou S, Rey F, "et al." |title=Human immunodeficiency virus type 1 Vpr protein binds to the uracil DNA glycosylase DNA repair enzyme. |journal=J. Virol. |volume=70 |issue= 2 |pages= 697–704 |year= 1996 |pmid= 8551605 |doi=
*cite journal | author=Kavli B, Slupphaug G, Mol CD, "et al." |title=Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase. |journal=EMBO J. |volume=15 |issue= 13 |pages= 3442–7 |year= 1996 |pmid= 8670846 |doi=
*cite journal | author=Haug T, Skorpen F, Kvaløy K, "et al." |title=Human uracil-DNA glycosylase gene: sequence organization, methylation pattern, and mapping to chromosome 12q23-q24.1. |journal=Genomics |volume=36 |issue= 3 |pages= 408–16 |year= 1997 |pmid= 8884263 |doi= 10.1006/geno.1996.0485
*cite journal | author=Slupphaug G, Mol CD, Kavli B, "et al." |title=A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA. |journal=Nature |volume=384 |issue= 6604 |pages= 87–92 |year= 1996 |pmid= 8900285 |doi= 10.1038/384087a0
*cite journal | author=Nilsen H, Otterlei M, Haug T, "et al." |title=Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene. |journal=Nucleic Acids Res. |volume=25 |issue= 4 |pages= 750–5 |year= 1997 |pmid= 9016624 |doi=
*cite journal | author=Nagelhus TA, Haug T, Singh KK, "et al." |title=A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit of replication protein A. |journal=J. Biol. Chem. |volume=272 |issue= 10 |pages= 6561–6 |year= 1997 |pmid= 9045683 |doi=
*cite journal | author=Selig L, Benichou S, Rogel ME, "et al." |title=Uracil DNA glycosylase specifically interacts with Vpr of both human immunodeficiency virus type 1 and simian immunodeficiency virus of sooty mangabeys, but binding does not correlate with cell cycle arrest. |journal=J. Virol. |volume=71 |issue= 6 |pages= 4842–6 |year= 1997 |pmid= 9151883 |doi=
*cite journal | author=Withers-Ward ES, Jowett JB, Stewart SA, "et al." |title=Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair. |journal=J. Virol. |volume=71 |issue= 12 |pages= 9732–42 |year= 1997 |pmid= 9371639 |doi=
*cite journal | author=Haug T, Skorpen F, Aas PA, "et al." |title=Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase. |journal=Nucleic Acids Res. |volume=26 |issue= 6 |pages= 1449–57 |year= 1998 |pmid= 9490791 |doi=

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