Thymine-DNA glycosylase

Thymine-DNA glycosylase

Thymine-DNA glycosylase, also known as TDG, is a human gene.cite web | title = Entrez Gene: TDG thymine-DNA glycosylase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6996| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.cite web | title = Entrez Gene: TDG thymine-DNA glycosylase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6996| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lindahl T |title=DNA repair enzymes. |journal=Annu. Rev. Biochem. |volume=51 |issue= |pages= 61–87 |year= 1982 |pmid= 6287922 |doi= 10.1146/annurev.bi.51.070182.000425
*cite journal | author=Hardeland U, Bentele M, Lettieri T, "et al." |title=Thymine DNA glycosylase. |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=68 |issue= |pages= 235–53 |year= 2001 |pmid= 11554300 |doi=
*cite journal | author=Chevray PM, Nathans D |title=Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 13 |pages= 5789–93 |year= 1992 |pmid= 1631061 |doi=
*cite journal | author=Neddermann P, Jiricny J |title=Efficient removal of uracil from G.U mispairs by the mismatch-specific thymine DNA glycosylase from HeLa cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 5 |pages= 1642–6 |year= 1994 |pmid= 8127859 |doi=
*cite journal | author=Neddermann P, Jiricny J |title=The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells. |journal=J. Biol. Chem. |volume=268 |issue= 28 |pages= 21218–24 |year= 1993 |pmid= 8407958 |doi=
*cite journal | author=Neddermann P, Gallinari P, Lettieri T, "et al." |title=Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase. |journal=J. Biol. Chem. |volume=271 |issue= 22 |pages= 12767–74 |year= 1996 |pmid= 8662714 |doi=
*cite journal | author=Sard L, Tornielli S, Gallinari P, "et al." |title=Chromosomal localizations and molecular analysis of TDG gene-related sequences. |journal=Genomics |volume=44 |issue= 2 |pages= 222–6 |year= 1997 |pmid= 9299239 |doi= 10.1006/geno.1997.4843
*cite journal | author=Barrett TE, Savva R, Panayotou G, "et al." |title=Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions. |journal=Cell |volume=92 |issue= 1 |pages= 117–29 |year= 1998 |pmid= 9489705 |doi=
*cite journal | author=Missero C, Pirro MT, Simeone S, "et al." |title=The DNA glycosylase T:G mismatch-specific thymine DNA glycosylase represses thyroid transcription factor-1-activated transcription. |journal=J. Biol. Chem. |volume=276 |issue= 36 |pages= 33569–75 |year= 2001 |pmid= 11438542 |doi= 10.1074/jbc.M104963200
*cite journal | author=Tini M, Benecke A, Um SJ, "et al." |title=Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. |journal=Mol. Cell |volume=9 |issue= 2 |pages= 265–77 |year= 2002 |pmid= 11864601 |doi=
*cite journal | author=Hardeland U, Steinacher R, Jiricny J, Schär P |title=Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover. |journal=EMBO J. |volume=21 |issue= 6 |pages= 1456–64 |year= 2002 |pmid= 11889051 |doi= 10.1093/emboj/21.6.1456
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Abu M, Waters TR |title=The main role of human thymine-DNA glycosylase is removal of thymine produced by deamination of 5-methylcytosine and not removal of ethenocytosine. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8739–44 |year= 2003 |pmid= 12493755 |doi= 10.1074/jbc.M211084200
*cite journal | author=Shimizu Y, Iwai S, Hanaoka F, Sugasawa K |title=Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase. |journal=EMBO J. |volume=22 |issue= 1 |pages= 164–73 |year= 2003 |pmid= 12505994 |doi= 10.1093/emboj/cdg016
*cite journal | author=Chen D, Lucey MJ, Phoenix F, "et al." |title=T:G mismatch-specific thymine-DNA glycosylase potentiates transcription of estrogen-regulated genes through direct interaction with estrogen receptor alpha. |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 38586–92 |year= 2003 |pmid= 12874288 |doi= 10.1074/jbc.M304286200
*cite journal | author=Lehner B, Semple JI, Brown SE, "et al." |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Krześniak M, Butkiewicz D, Samojedny A, "et al." |title=Polymorphisms in TDG and MGMT genes - epidemiological and functional study in lung cancer patients from Poland. |journal=Ann. Hum. Genet. |volume=68 |issue= Pt 4 |pages= 300–12 |year= 2005 |pmid= 15225156 |doi= 10.1046/j.1529-8817.2004.00079.x

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • Thymine DNA glycosylase — Figure 1: Exemple de membres de la famille des glycosylases humaines. La thymine DNA glycosylase ou G/T mismatch specific thymine DNA glycosylse (TDG) est une enzyme. Chez l homme c est une protéine monomérique de 410 acides aminés codés par 1233 …   Wikipédia en Français

  • DNA glycosylase — DNA glycosylases are a family of enzymes involved in base excision repair, classified under EC number EC 3.2.2. Base excision repair is the mechanism by which damaged bases in DNA are removed and replaced. DNA glycosylases catalyze the first step …   Wikipedia

  • Uracil-DNA glycosylase — Uracil DNA glycosylase, also known as UNG, is a human gene.cite web | title = Entrez Gene: UNG uracil DNA glycosylase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=7374| accessdate = ] PBB Summary section …   Wikipedia

  • DNA demethylation — is a process of removal of methyl group from nucleotide in DNA. DNA demethylation could be passive and active. Passive process takes place in the absence of methylation of newly synthesised DNA strands by DNMT1 during several replication rounds… …   Wikipedia

  • Glycosylase — Exemple de membres de la famille des glycosylases humaines. Les glycosylases d ADN sont une famille d enzymes hydrolases découverte par un Thomas Lindhal autour des années 1975 lorsqu il étudiait le processus de réparation de l ADN mise en œuvre… …   Wikipédia en Français

  • Glycosylase d'ADN — Exemple de membres de la famille des glycosylases humaines. Les glycosylases d ADN sont une famille d enzymes hydrolases découverte par un Thomas Lindhal autour des années 1975 lorsqu il étudiait le processus de réparation de l ADN mise en œuvre… …   Wikipédia en Français

  • DNA repair — For the journal, see DNA Repair (journal). DNA damage resulting in multiple broken chromosomes DNA repair refers to a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human… …   Wikipedia

  • TDG — (= thymine DNA glycosylase.) Enzyme responsible for repair of G/T mispairings …   Dictionary of molecular biology

  • Base excision repair — (BER) is a cellular mechanism that repairs damaged DNA throughout the cell cycle. Repairing DNA sequence errors is necessary so that mutations are not propagated or to remove lesions that may lead to breaks in the DNA during replication.Single… …   Wikipedia

  • Deamination — is the removal of an amine group from a molecule. Enzymes which catalyse this reaction are called deaminases. In the human body, deamination takes place primarily in the liver, however glutamate is also deaminated in the kidneys. Deamination is… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”