Thymine-DNA glycosylase

Thymine-DNA glycosylase

Thymine-DNA glycosylase, also known as TDG, is a human gene.cite web | title = Entrez Gene: TDG thymine-DNA glycosylase| url =| accessdate = ]

section_title =
summary_text = The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.cite web | title = Entrez Gene: TDG thymine-DNA glycosylase| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Lindahl T |title=DNA repair enzymes. |journal=Annu. Rev. Biochem. |volume=51 |issue= |pages= 61–87 |year= 1982 |pmid= 6287922 |doi= 10.1146/
*cite journal | author=Hardeland U, Bentele M, Lettieri T, "et al." |title=Thymine DNA glycosylase. |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=68 |issue= |pages= 235–53 |year= 2001 |pmid= 11554300 |doi=
*cite journal | author=Chevray PM, Nathans D |title=Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 13 |pages= 5789–93 |year= 1992 |pmid= 1631061 |doi=
*cite journal | author=Neddermann P, Jiricny J |title=Efficient removal of uracil from G.U mispairs by the mismatch-specific thymine DNA glycosylase from HeLa cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 5 |pages= 1642–6 |year= 1994 |pmid= 8127859 |doi=
*cite journal | author=Neddermann P, Jiricny J |title=The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells. |journal=J. Biol. Chem. |volume=268 |issue= 28 |pages= 21218–24 |year= 1993 |pmid= 8407958 |doi=
*cite journal | author=Neddermann P, Gallinari P, Lettieri T, "et al." |title=Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase. |journal=J. Biol. Chem. |volume=271 |issue= 22 |pages= 12767–74 |year= 1996 |pmid= 8662714 |doi=
*cite journal | author=Sard L, Tornielli S, Gallinari P, "et al." |title=Chromosomal localizations and molecular analysis of TDG gene-related sequences. |journal=Genomics |volume=44 |issue= 2 |pages= 222–6 |year= 1997 |pmid= 9299239 |doi= 10.1006/geno.1997.4843
*cite journal | author=Barrett TE, Savva R, Panayotou G, "et al." |title=Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions. |journal=Cell |volume=92 |issue= 1 |pages= 117–29 |year= 1998 |pmid= 9489705 |doi=
*cite journal | author=Missero C, Pirro MT, Simeone S, "et al." |title=The DNA glycosylase T:G mismatch-specific thymine DNA glycosylase represses thyroid transcription factor-1-activated transcription. |journal=J. Biol. Chem. |volume=276 |issue= 36 |pages= 33569–75 |year= 2001 |pmid= 11438542 |doi= 10.1074/jbc.M104963200
*cite journal | author=Tini M, Benecke A, Um SJ, "et al." |title=Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. |journal=Mol. Cell |volume=9 |issue= 2 |pages= 265–77 |year= 2002 |pmid= 11864601 |doi=
*cite journal | author=Hardeland U, Steinacher R, Jiricny J, Schär P |title=Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover. |journal=EMBO J. |volume=21 |issue= 6 |pages= 1456–64 |year= 2002 |pmid= 11889051 |doi= 10.1093/emboj/21.6.1456
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Abu M, Waters TR |title=The main role of human thymine-DNA glycosylase is removal of thymine produced by deamination of 5-methylcytosine and not removal of ethenocytosine. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8739–44 |year= 2003 |pmid= 12493755 |doi= 10.1074/jbc.M211084200
*cite journal | author=Shimizu Y, Iwai S, Hanaoka F, Sugasawa K |title=Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase. |journal=EMBO J. |volume=22 |issue= 1 |pages= 164–73 |year= 2003 |pmid= 12505994 |doi= 10.1093/emboj/cdg016
*cite journal | author=Chen D, Lucey MJ, Phoenix F, "et al." |title=T:G mismatch-specific thymine-DNA glycosylase potentiates transcription of estrogen-regulated genes through direct interaction with estrogen receptor alpha. |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 38586–92 |year= 2003 |pmid= 12874288 |doi= 10.1074/jbc.M304286200
*cite journal | author=Lehner B, Semple JI, Brown SE, "et al." |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Krześniak M, Butkiewicz D, Samojedny A, "et al." |title=Polymorphisms in TDG and MGMT genes - epidemiological and functional study in lung cancer patients from Poland. |journal=Ann. Hum. Genet. |volume=68 |issue= Pt 4 |pages= 300–12 |year= 2005 |pmid= 15225156 |doi= 10.1046/j.1529-8817.2004.00079.x

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