Stearoyl-CoA desaturase-1

Stearoyl-CoA desaturase (delta-9-desaturase)
Identifiers
Symbols	SCD; FADS5; MSTP008; SCD1; SCDOS
External IDs	OMIM: 604031 HomoloGene: 74538 GeneCards: SCD Gene
EC number	1.14.19.1
Gene Ontology Molecular function • stearoyl-CoA 9-desaturase activity • iron ion binding • oxidoreductase activity • oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water Cellular component • endoplasmic reticulum • endoplasmic reticulum membrane • membrane • integral to membrane Biological process • fatty acid biosynthetic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6319	20249
Ensembl	ENSG00000099194	ENSMUSG00000037071
UniProt	O00767	P13516
RefSeq (mRNA)	NM_005063.4	NM_009127.4
RefSeq (protein)	NP_005054.3	NP_033153.2
Location (UCSC)	Chr 10: 102.11 – 102.12 Mb	Chr 19: 44.47 – 44.48 Mb
PubMed search	[1]	[2]
This box: view · protein that in humans is encoded by the SCD gene.[1] Stearoyl-CoA desaturase-1is a key enzyme in fatty acid metabolism. It is responsible for forming a double bond in Stearoyl-CoA. This is how the monounsaturated fatty acid oleic acid is produced from the saturated fatty acid stearic acid. Stearoyl-CoA desaturase (SCD; EC 1.14.19.1) is an iron-containing enzyme that catalyzes a rate-limiting step in the synthesis of unsaturated fatty acids. The principal product of SCD is oleic acid, which is formed by desaturation of stearic acid. The ratio of stearic acid to oleic acid has been implicated in the regulation of cell growth and differentiation through effects on cell membrane fluidity and signal transduction. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 and SCD5 (MIM 608370), have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates.[2][3][1] References ^ a b "Entrez Gene: Stearoyl-CoA desaturase (delta-9-desaturase)". http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=6319. Retrieved 2011-09-29T21:11:57.607-07:00.  ^ Zhang, L.; Ge, L.; Parimoo, S.; Stenn, K.; Prouty, S. M. (1999). "Human stearoyl-CoA desaturase: Alternative transcripts generated from a single gene by usage of tandem polyadenylation sites". The Biochemical journal 340 ( Pt 1) (Pt 1): 255–264. PMC 1220244. PMID 10229681. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220244.  edit ^ Wang J, Yu L, Schmidt RE, Su C, Huang X, Gould K, Cao G (July 2005). "Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates". Biochem. Biophys. Res. Commun. 332 (3): 735–42. doi:10.1016/j.bbrc.2005.05.013. PMID 15907797.  Further reading Zhang, L.; Ge, L.; Parimoo, S.; Stenn, K.; Prouty, S. M. (1999). "Human stearoyl-CoA desaturase: Alternative transcripts generated from a single gene by usage of tandem polyadenylation sites". The Biochemical journal 340 ( Pt 1) (Pt 1): 255–264. PMC 1220244. PMID 10229681. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220244.  edit Mziaut, H.; Korza, G.; Ozols, J. (2000). "The N terminus of microsomal Δ9 stearoyl-CoA desaturase contains the sequence determinant for its rapid degradation". Proceedings of the National Academy of Sciences of the United States of America 97 (16): 8883–8888. PMC 16790. PMID 10922050. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16790.  edit Samuel, W.; Kutty, R. K.; Nagineni, S.; Gordon, J. S.; Prouty, S. M.; Chandraratna, R. A.; Wiggert, B. (2001). "Regulation of Stearoyl Coenzyme a Desaturase Expression in Human Retinal Pigment Epithelial Cells by Retinoic Acid". Journal of Biological Chemistry 276 (31): 28744–28750. doi:10.1074/jbc.M103587200. PMID 11397803.  edit Zhang, L.; Ge, L.; Tran, T.; Stenn, K.; Prouty, S. M. (2001). "Isolation and characterization of the human stearoyl-CoA desaturase gene promoter: Requirement of a conserved CCAAT cis-element". The Biochemical journal 357 (Pt 1): 183–193. PMC 1221940. PMID 11415448. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1221940.  edit Samuel, W.; Nagineni, C. N.; Kutty, R. K.; Parks, W. T.; Gordon, J. S.; Prouty, S. M.; Hooks, J. J.; Wiggert, B. (2001). "Transforming Growth Factor-beta Regulates Stearoyl Coenzyme a Desaturase Expression through a Smad Signaling Pathway". Journal of Biological Chemistry 277 (1): 59–66. doi:10.1074/jbc.M108730200. PMID 11677241.  edit Choi, Y.; Park, Y.; Storkson, J. M.; Pariza, M. W.; Ntambi, J. M. (2002). "Inhibition of stearoyl-CoA desaturase activity by the cis-9,trans-11 isomer and the trans-10,cis-12 isomer of conjugated linoleic acid in MDA-MB-231 and MCF-7 human breast cancer cells". Biochemical and Biophysical Research Communications 294 (4): 785–790. doi:10.1016/S0006-291X(02)00554-5. PMID 12061775.  edit Attie, A. D.; Krauss, R. M.; Gray-Keller, M. P.; Brownlie, A.; Miyazaki, M.; Kastelein, J. J.; Lusis, A. J.; Stalenhoef, A. F. et al. (2002). "Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia". Journal of lipid research 43 (11): 1899–1907. PMID 12401889.  edit Cohen, P.; Ntambi, J. M.; Friedman, J. M. (2003). "Stearoyl-CoA desaturase-1 and the metabolic syndrome". Current drug targets. Immune, endocrine and metabolic disorders 3 (4): 271–280. PMID 14683458.  edit Shiwaku, K.; Hashimoto, M.; Kitajima, K.; Nogi, A.; Anuurad, E.; Enkhmaa, B.; Kim, J. M.; Kim, I. S. et al. (2004). "Triglyceride levels are ethnic-specifically associated with an index of stearoyl-CoA desaturase activity and n-3 PUFA levels in Asians". The Journal of Lipid Research 45 (5): 914–922. doi:10.1194/jlr.M300483-JLR200. PMID 14967817.  edit Wang, Y.; Kurdi-Haidar, B.; Oram, J. F. (2004). "LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1". The Journal of Lipid Research 45 (5): 972–980. doi:10.1194/jlr.M400011-JLR200. PMID 14967823.  edit Rahman SM, Dobrzyn A, Dobrzyn P et al. (2003). "Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle". Proc. Natl. Acad. Sci. U.S.A. 100 (19): 11110–5. doi:10.1073/pnas.1934571100. PMC 196935. PMID 12960377. http://www.pnas.org/cgi/content/abstract/100/19/11110.  External links MeSH Stearoyl-CoA+Desaturase Wikimedia Foundation. 2010. Игры ⚽ Поможем сделать НИР St Andrew's and St George's Church St. John's Island, Egypt Look at other dictionaries: Stearoyl-CoA 9-desaturase — In enzymology, a stearoyl CoA 9 desaturase (EC number|1.14.19.1) is an enzyme that catalyzes the chemical reaction:stearoyl CoA + 2 ferrocytochrome b5 + O2 + 2 H+ ightleftharpoons oleoyl CoA + 2 ferricytochrome b5 + 2 H2OThe 4 substrates of this… …   Wikipedia stearoyl-CoA 9-desaturase — ste·a·ro·yl CoA 9 de·sat·u·rase (ste arґo əl ko aґ de sachґu rās) [EC 1.14.19.5] an enzyme activity of the oxidoreductase class that catalyzes the desaturation of stearoyl coenzyme A to form oleoyl coenzyme A. It is part of a complex in …   Medical dictionary acyl-CoA desaturase — acyl CoA de·sat·ur·ase (aґsəl ko aґ de sachґə rās) stearoyl CoA 9 desaturase …   Medical dictionary Desaturase — A Desaturase is an enzyme which removes two hydrogen atoms from an organic compound, creating a carbon/carbon double bond. Desaturases are classified as * delta indicating that the double bond is created at a fixed position from the carboxyl… …   Wikipedia desaturase — de·sat·ur·ase (de sachґə rās) an enzyme that, complexed with cytochrome b5 reductase and cytochrome b5, catalyzes the desaturation of fatty acids, e.g., stearoyl CoA desaturase …   Medical dictionary Fatty acid desaturase — Fatty acid desaturase, type 1 Identifiers Symbol Fatty acid desaturase 1 Pfam PF00487 InterPro …   Wikipedia Lipid — Structures of some common lipids. At the top are oleic acid[1] and cholesterol.[2] The middle structure is a triglyceride composed of oleoyl, stearoyl, and palmitoyl chains at …   Wikipedia Cholesterol side-chain cleavage enzyme — Cytochrome P450, family 11, subfamily A, polypeptide 1 Identifiers Symbols CYP11A1; CYP11A; P450SCC External IDs …   Wikipedia Cholesterol 7 alpha-hydroxylase — Cytochrome P450, family 7, subfamily A, polypeptide 1 PDB rendering based on 3dax …   Wikipedia Steroid 11-beta-hydroxylase — Cytochrome P450, family 11, subfamily B, polypeptide 1 Identifiers Symbols CYP11B1; CPN1; CYP11B; DKFZp686B05283; FHI; FLJ36771; P450C11 External IDs …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”