FMO2

Flavin containing monooxygenase 2 (non-functional), also known as FMO2, is a human gene.cite web | title = Entrez Gene: FMO2 flavin containing monooxygenase 2 (non-functional)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2327| accessdate = ]

PBB_Summary
section_title =
summary_text = The flavin-containing monooxygenases are NADPH-dependent enzymes that catalyze the oxidation of many drugs and xenobiotics. In most mammals, there is a flavin-containing monooxygenase that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, in humans, this enzyme is truncated and is probably rapidly degraded. The protein encoded by this gene represents the truncated form and apparently has no catalytic activity. A functional allele found in African Americans has been reported, but no sequence evidence has been deposited to support the finding. This gene is found in a cluster with the FMO1, FMO3, and FMO4 genes on chromosome 1.cite web | title = Entrez Gene: FMO2 flavin containing monooxygenase 2 (non-functional)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2327| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hines RN, Cashman JR, Philpot RM, "et al." |title=The mammalian flavin-containing monooxygenases: molecular characterization and regulation of expression. |journal=Toxicol. Appl. Pharmacol. |volume=125 |issue= 1 |pages= 1–6 |year= 1994 |pmid= 8128486 |doi= 10.1006/taap.1994.1042
*cite journal | author=Dolphin CT, Shephard EA, Povey S, "et al." |title=Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family. |journal=Biochem. J. |volume=287 ( Pt 1) |issue= |pages= 261–7 |year= 1992 |pmid= 1417778 |doi=
*cite journal | author=Lomri N, Gu Q, Cashman JR |title=Molecular cloning of the flavin-containing monooxygenase (form II) cDNA from adult human liver. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 5 |pages= 1685–9 |year= 1992 |pmid= 1542660 |doi=
*cite journal | author=Phillips IR, Dolphin CT, Clair P, "et al." |title=The molecular biology of the flavin-containing monooxygenases of man. |journal=Chem. Biol. Interact. |volume=96 |issue= 1 |pages= 17–32 |year= 1995 |pmid= 7720101 |doi=
*cite journal | author=Lawton MP, Cashman JR, Cresteil T, "et al." |title=A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities. |journal=Arch. Biochem. Biophys. |volume=308 |issue= 1 |pages= 254–7 |year= 1994 |pmid= 8311461 |doi=
*cite journal | author=McCombie RR, Dolphin CT, Povey S, "et al." |title=Localization of human flavin-containing monooxygenase genes FMO2 and FMO5 to chromosome 1q. |journal=Genomics |volume=34 |issue= 3 |pages= 426–9 |year= 1996 |pmid= 8786146 |doi= 10.1006/geno.1996.0308
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Dolphin CT, Beckett DJ, Janmohamed A, "et al." |title=The flavin-containing monooxygenase 2 gene (FMO2) of humans, but not of other primates, encodes a truncated, nonfunctional protein. |journal=J. Biol. Chem. |volume=273 |issue= 46 |pages= 30599–607 |year= 1998 |pmid= 9804831 |doi=
*cite journal | author=Whetstine JR, Yueh MF, McCarver DG, "et al." |title=Ethnic differences in human flavin-containing monooxygenase 2 (FMO2) polymorphisms: detection of expressed protein in African-Americans. |journal=Toxicol. Appl. Pharmacol. |volume=168 |issue= 3 |pages= 216–24 |year= 2000 |pmid= 11042094 |doi= 10.1006/taap.2000.9050
*cite journal | author=Krueger SK, Martin SR, Yueh MF, "et al." |title=Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein. |journal=Drug Metab. Dispos. |volume=30 |issue= 1 |pages= 34–41 |year= 2002 |pmid= 11744609 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Furnes B, Feng J, Sommer SS, Schlenk D |title=Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans. |journal=Drug Metab. Dispos. |volume=31 |issue= 2 |pages= 187–93 |year= 2003 |pmid= 12527699 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Krueger SK, Siddens LK, Henderson MC, "et al." |title=Haplotype and functional analysis of four flavin-containing monooxygenase isoform 2 (FMO2) polymorphisms in Hispanics. |journal=Pharmacogenet. Genomics |volume=15 |issue= 4 |pages= 245–56 |year= 2005 |pmid= 15864117 |doi=
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727

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