ALOX15B

Arachidonate 15-lipoxygenase, type B, also known as ALOX15B, is a human gene.cite web | title = Entrez Gene: ALOX15B arachidonate 15-lipoxygenase, type B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=247| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.cite web | title = Entrez Gene: ALOX15B arachidonate 15-lipoxygenase, type B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=247| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sigal E, Grunberger D, Highland E, "et al." |title=Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related. |journal=J. Biol. Chem. |volume=265 |issue= 9 |pages= 5113–20 |year= 1990 |pmid= 2318885 |doi=
*cite journal | author=Brash AR, Boeglin WE, Chang MS |title=Discovery of a second 15S-lipoxygenase in humans. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 12 |pages= 6148–52 |year= 1997 |pmid= 9177185 |doi=
*cite journal | author=Kilty I, Logan A, Vickers PJ |title=Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase. |journal=Eur. J. Biochem. |volume=266 |issue= 1 |pages= 83–93 |year= 2000 |pmid= 10542053 |doi=
*cite journal | author=Krieg P, Marks F, Fürstenberger G |title=A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression. |journal=Genomics |volume=73 |issue= 3 |pages= 323–30 |year= 2001 |pmid= 11350124 |doi= 10.1006/geno.2001.6519
*cite journal | author=Tang S, Bhatia B, Maldonado CJ, "et al." |title=Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 16189–201 |year= 2002 |pmid= 11839751 |doi= 10.1074/jbc.M111936200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Xu XC, Shappell SB, Liang Z, "et al." |title=Reduced 15S-lipoxygenase-2 expression in esophageal cancer specimens and cells and upregulation in vitro by the cyclooxygenase-2 inhibitor, NS398. |journal=Neoplasia |volume=5 |issue= 2 |pages= 121–7 |year= 2003 |pmid= 12659684 |doi=
*cite journal | author=Bhatia B, Maldonado CJ, Tang S, "et al." |title=Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants. |journal=J. Biol. Chem. |volume=278 |issue= 27 |pages= 25091–100 |year= 2003 |pmid= 12704195 |doi= 10.1074/jbc.M301920200
*cite journal | author=Tang S, Bhatia B, Zhou J, "et al." |title=Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cells. |journal=Oncogene |volume=23 |issue= 41 |pages= 6942–53 |year= 2004 |pmid= 15247906 |doi= 10.1038/sj.onc.1207913
*cite journal | author=Suzuki Y, Yamashita R, Shirota M, "et al." |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Limor R, Kaplan M, Sawamura T, "et al." |title=Angiotensin II increases the expression of lectin-like oxidized low-density lipoprotein receptor-1 in human vascular smooth muscle cells via a lipoxygenase-dependent pathway. |journal=Am. J. Hypertens. |volume=18 |issue= 3 |pages= 299–307 |year= 2005 |pmid= 15797645 |doi= 10.1016/j.amjhyper.2004.09.008
*cite journal | author=Subbarayan V, Xu XC, Kim J, "et al." |title=Inverse relationship between 15-lipoxygenase-2 and PPAR-gamma gene expression in normal epithelia compared with tumor epithelia. |journal=Neoplasia |volume=7 |issue= 3 |pages= 280–93 |year= 2005 |pmid= 15799828 |doi= 10.1593/neo.04457
*cite journal | author=Jiang WG, Watkins G, Douglas-Jones A, Mansel RE |title=Reduction of isoforms of 15-lipoxygenase (15-LOX)-1 and 15-LOX-2 in human breast cancer. |journal=Prostaglandins Leukot. Essent. Fatty Acids |volume=74 |issue= 4 |pages= 235–45 |year= 2006 |pmid= 16556493 |doi= 10.1016/j.plefa.2006.01.009
*cite journal | author=Subbarayan V, Krieg P, Hsi LC, "et al." |title=15-Lipoxygenase-2 gene regulation by its product 15-(S)-hydroxyeicosatetraenoic acid through a negative feedback mechanism that involves peroxisome proliferator-activated receptor gamma. |journal=Oncogene |volume=25 |issue= 44 |pages= 6015–25 |year= 2006 |pmid= 16682954 |doi= 10.1038/sj.onc.1209617
*cite journal | author=Lesueur F, Bouadjar B, Lefèvre C, "et al." |title=Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13. |journal=J. Invest. Dermatol. |volume=127 |issue= 4 |pages= 829–34 |year= 2007 |pmid= 17139268 |doi= 10.1038/sj.jid.5700640

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