PLAT domain

PLAT domain

Pfam_box
Symbol = PLAT
Name = PLAT/LH2 domain


width =
caption =
Pfam= PF01477
InterPro= IPR001024
SMART=
PROSITE = PDOC50095
SCOP = 1lpa
TCDB =
OPM family= 88
OPM protein= 1zq4
PDB=PDB3|1zq4A:374-490 PDB3|1lox :2-112 PDB3|1bu8A:356-468PDB3|1hplB:351-461 PDB3|1ethC:339-450 PDB3|1lpaB:355-465PDB3|1gpl :355-465 PDB3|1n8sA:355-465 PDB3|1lpbB:355-465PDB3|1rp1 :356-467 PDB3|1y4kA:40-143 PDB3|2sblB:40-143PDB3|1fgoA:40-143 PDB3|1fgmA:40-143 PDB3|1yge :40-143PDB3|1fgtA:40-143 PDB3|1f8nA:40-143 PDB3|1fgqA:40-143PDB3|1fgrA:40-143 PDB3|1rrhA:58-161 PDB3|1rovA:58-161PDB3|1lnh :58-161 PDB3|1no3A:58-161 PDB3|1n8qA:58-161PDB3|1rrlB:58-161 PDB3|1hu9A:58-161 PDB3|1ik3A:58-161PDB3|1jnqA:58-161

PLAT domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domaincite journal |author=Bateman A, Sandford R |title=The PLAT domain: a new piece in the PKD1 puzzle |journal=Curr. Biol. |volume=9 |issue=16 |pages=- |year=1999 |pmid=10469604 |doi=10.1016/S0960-9822(99)80380-7] or LH2 (Lipoxygenase homology) domaincite journal |author=Ponting CP, Hofmann K, Bork P |title=A latrophilin/CL-1-like GPS domain in polycystin-1 |journal=Curr. Biol. |volume=9 |issue=16 |pages=R585–8 |year=1999 |month=August |pmid=10469603 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(99)80379-0] . The known structureof pancreatic lipase shows this domain binds to procolipase Pfam|PF01114, which mediates membrane association.

This domain is found in a variety of membrane or lipid associated proteins. It forms a beta-sandwich composed of two sheets of four strands eachcite journal |author=Delrieu I, Waller CC, Mota MM, Grainger M, Langhorne J, Holder AA |title=PSLAP, a protein with multiple adhesive motifs, is expressed in Plasmodium falciparum gametocytes |journal=Mol. Biochem. Parasitol. |volume=121 |issue=1 |pages=- |year=2002 |pmid=11985859 |doi=10.1016/S0166-6851(02)00016-6] cite journal |author=Minor W, Tomchick DR, Phan P, Cymborowski M, Holman TR |title=Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1 |journal=Biochemistry |volume=40 |issue=25 |pages=7509–7517 |year=2001 |pmid=11412104 |doi=10.1021/bi002893d] .

Human proteins containing this domain

ALOX12; ALOX12B; ALOX12P2; ALOX15; ALOX15B; ALOX5; ALOXE3; LIPC;
LIPG; LOXHD1; LPL; PKD1; PKD1L1; PKD1L2; PKD1L3; PKDREJ;
PNLIP; PNLIPRP1; PNLIPRP2; PNLIPRP3; RAB6IP1;

References


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