Stearoyl-CoA 9-desaturase
- Stearoyl-CoA 9-desaturase
In enzymology, a stearoyl-CoA 9-desaturase (EC number|1.14.19.1) is an enzyme that catalyzes the chemical reaction
:stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
The 4 substrates of this enzyme are stearoyl-CoA, ferrocytochrome b5, O2, and H+, whereas its 3 products are oleoyl-CoA, ferricytochrome b5, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with oxidation of a pair of donors resulting in the reduction of O to two molecules of water. The systematic name of this enzyme class is stearoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (9,10-dehydrogenating). Other names in common use include Delta9-desaturase, acyl-CoA desaturase, fatty acid desaturase, and stearoyl-CoA, hydrogen-donor:oxygen oxidoreductase. This enzyme participates in polyunsaturated fatty acid biosynthesis and ppar signaling pathway. It employs one cofactor, iron.
References
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External links
::"The CAS registry number for this enzyme class is CAS registry|9014-34-0."
Gene Ontology (GO) codes
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stearoyl-CoA 9-desaturase — ste·a·ro·yl CoA 9 de·sat·u·rase (ste arґo əl ko aґ de sachґu rās) [EC 1.14.19.5] an enzyme activity of the oxidoreductase class that catalyzes the desaturation of stearoyl coenzyme A to form oleoyl coenzyme A. It is part of a complex in … Medical dictionary
Stearoyl-CoA desaturase-1 — Stearoyl CoA desaturase (delta 9 desaturase) Identifiers Symbols SCD; FADS5; MSTP008; SCD1; SCDOS External IDs … Wikipedia
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desaturase — de·sat·ur·ase (de sachґə rās) an enzyme that, complexed with cytochrome b5 reductase and cytochrome b5, catalyzes the desaturation of fatty acids, e.g., stearoyl CoA desaturase … Medical dictionary
acyl-CoA desaturase — acyl CoA de·sat·ur·ase (aґsəl ko aґ de sachґə rās) stearoyl CoA 9 desaturase … Medical dictionary
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Cytochrome b5 — Rat cytochrome b5 bound to heme Identifiers Symbol CYB5A Alt. symbols CYB5 … Wikipedia
Oleic acid — Oleic acid … Wikipedia
Lipid — Structures of some common lipids. At the top are oleic acid[1] and cholesterol.[2] The middle structure is a triglyceride composed of oleoyl, stearoyl, and palmitoyl chains at … Wikipedia
