Thromboxane-A synthase

Thromboxane-A synthase

Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A), also known as TBXAS1, is a human gene.cite web | title = Entrez Gene: TBXAS1 thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6916| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The ccytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostaglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. The gene expresses two transcript variants.cite web | title = Entrez Gene: TBXAS1 thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6916| accessdate = ]

Pathway

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Shen RF, Tai HH |title=Thromboxanes: synthase and receptors. |journal=J. Biomed. Sci. |volume=5 |issue= 3 |pages= 153–72 |year= 1998 |pmid= 9678486 |doi=
*cite journal | author=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129–65 |year= 1999 |pmid= 9890157 |doi=
*cite journal | author=Wang LH, Kulmacz RJ |title=Thromboxane synthase: structure and function of protein and gene. |journal=Prostaglandins Other Lipid Mediat. |volume=68-69 |issue= |pages= 409–22 |year= 2003 |pmid= 12432933 |doi=
*cite journal | author=Itoh S, Yanagimoto T, Tagawa S, "et al." |title=Genomic organization of human fetal specific P-450IIIA7 (cytochrome P-450HFLa)-related gene(s) and interaction of transcriptional regulatory factor with its DNA element in the 5' flanking region. |journal=Biochim. Biophys. Acta |volume=1130 |issue= 2 |pages= 133–8 |year= 1992 |pmid= 1562592 |doi=
*cite journal | author=Yokoyama C, Miyata A, Ihara H, "et al." |title=Molecular cloning of human platelet thromboxane A synthase. |journal=Biochem. Biophys. Res. Commun. |volume=178 |issue= 3 |pages= 1479–84 |year= 1991 |pmid= 1714723 |doi=
*cite journal | author=Ohashi K, Ruan KH, Kulmacz RJ, "et al." |title=Primary structure of human thromboxane synthase determined from the cDNA sequence. |journal=J. Biol. Chem. |volume=267 |issue= 2 |pages= 789–93 |year= 1992 |pmid= 1730669 |doi=
*cite journal | author=Jones DA, Fitzpatrick FA, Malcolm KC |title=Thromboxane A2 synthesis in human erythroleukemia cells. |journal=Biochem. Biophys. Res. Commun. |volume=180 |issue= 1 |pages= 8–14 |year= 1991 |pmid= 1930241 |doi=
*cite journal | author=Wang LH, Ohashi K, Wu KK |title=Isolation of partial complementary DNA encoding human thromboxane synthase. |journal=Biochem. Biophys. Res. Commun. |volume=177 |issue= 1 |pages= 286–91 |year= 1991 |pmid= 2043115 |doi=
*cite journal | author=Nüsing R, Schneider-Voss S, Ullrich V |title=Immunoaffinity purification of human thromboxane synthase. |journal=Arch. Biochem. Biophys. |volume=280 |issue= 2 |pages= 325–30 |year= 1990 |pmid= 2195994 |doi=
*cite journal | author=Mestel F, Oetliker O, Beck E, "et al." |title=Severe bleeding associated with defective thromboxane synthetase. |journal=Lancet |volume=1 |issue= 8160 |pages= 157 |year= 1980 |pmid= 6101498 |doi=
*cite journal | author=Miyata A, Yokoyama C, Ihara H, "et al." |title=Characterization of the human gene (TBXAS1) encoding thromboxane synthase. |journal=Eur. J. Biochem. |volume=224 |issue= 2 |pages= 273–9 |year= 1994 |pmid= 7925341 |doi=
*cite journal | author=Wang LH, Tazawa R, Lang AQ, Wu KK |title=Alternate splicing of human thromboxane synthase mRNA. |journal=Arch. Biochem. Biophys. |volume=315 |issue= 2 |pages= 273–8 |year= 1995 |pmid= 7986068 |doi= 10.1006/abbi.1994.1500
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Lee KD, Baek SJ, Shen RF |title=Cloning and characterization of the human thromboxane synthase gene promoter. |journal=Biochem. Biophys. Res. Commun. |volume=201 |issue= 1 |pages= 379–87 |year= 1994 |pmid= 8198598 |doi= 10.1006/bbrc.1994.1712
*cite journal | author=Chase MB, Baek SJ, Purtell DC, "et al." |title=Mapping of the human thromboxane synthase gene (TBXAS1) to chromosome 7q34-q35 by two-color fluorescence in situ hybridization. |journal=Genomics |volume=16 |issue= 3 |pages= 771–3 |year= 1993 |pmid= 8325653 |doi= 10.1006/geno.1993.1264
*cite journal | author=Ruan KH, Wang LH, Wu KK, Kulmacz RJ |title=Amino-terminal topology of thromboxane synthase in the endoplasmic reticulum. |journal=J. Biol. Chem. |volume=268 |issue= 26 |pages= 19483–90 |year= 1993 |pmid= 8366093 |doi=
*cite journal | author=Tazawa R, Green ED, Ohashi K, "et al." |title=Characterization of the complete genomic structure of human thromboxane synthase gene and functional analysis of its promoter. |journal=Arch. Biochem. Biophys. |volume=334 |issue= 2 |pages= 349–56 |year= 1996 |pmid= 8900410 |doi= 10.1006/abbi.1996.0464
*cite journal | author=Baek SJ, Lee KD, Shen RF |title=Genomic structure and polymorphism of the human thromboxane synthase-encoding gene. |journal=Gene |volume=173 |issue= 2 |pages= 251–6 |year= 1996 |pmid= 8964509 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=

ee also

* Prostanoid

External links

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