CYP1B1

Cytochrome P450, family 1, subfamily B, polypeptide 1
Identifiers
Symbols	CYP1B1; CP1B; GLC3A; P4501B1
External IDs	OMIM: 601771 MGI: 88590 HomoloGene: 68035 GeneCards: CYP1B1 Gene
EC number	1.14.14.1
Gene Ontology Molecular function • monooxygenase activity • protein binding • electron carrier activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • oxygen binding • oxygen binding • heme binding • metal ion binding • aromatase activity Cellular component • endoplasmic reticulum • endoplasmic reticulum membrane • microsome • membrane Biological process • angiogenesis • cellular aromatic compound metabolic process • xenobiotic metabolic process • visual perception • estrogen metabolic process • toxin metabolic process • response to toxin • response to organic substance • endothelial cell migration • oxidation-reduction process • retina vasculature development in camera-type eye • endothelial cell-cell adhesion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1545	13078
Ensembl	ENSG00000138061	ENSMUSG00000024087
UniProt	Q16678	Q3UTK2
RefSeq (mRNA)	NM_000104.3	NM_009994.1
RefSeq (protein)	NP_000095.2	NP_034124.1
Location (UCSC)	Chr 2: 38.29 – 38.34 Mb	Chr 17: 80.11 – 80.11 Mb
PubMed search	[1]	[2]

Cytochrome P450 1B1 is an enzyme that in humans is encoded by the CYP1B1 gene.^[1]

Function

CYP1B1 belongs to the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol.

Despite over 20 years of research of CYP1A1 and CYP1A2, CYP1B1 was not identified and sequenced until 1994. Nucleic and amino acid analysis showed approximately 40% identity with CYP1A1. Despite this similarity, these two enzymes have very different catalytic efficiencies and metabolites when incubated with common substrates, such as retinoic acid and arachidonic acid. Recently CYP1B1 has been shown to be physiologically important in fetal development, since mutations in CYP1B1 are linked with a form of primary congenital glaucoma.

CYP1A1 and CYP1B1 are regulated by the Aryl hydrocarbon receptor, a ligand activated transcription factor. They are part of the Phase I reactions in drug metabolism.

Clinical significance

Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid.^[1]

References

1. ^ ^{a b} "Entrez Gene: cytochrome P450". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1545. 

Further reading

• Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily.". Xenobiotica 28 (12): 1129–65. doi:10.1080/004982598238868. PMID 9890157. 
• Sasaki M, Kaneuchi M, Fujimoto S, et al. (2004). "CYP1B1 gene in endometrial cancer.". Mol. Cell. Endocrinol. 202 (1-2): 171–6. doi:10.1016/S0303-7207(03)00079-0. PMID 12770747. 
• Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.". Pharmacogenetics 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046. 
• Paracchini V, Raimondi S, Gram IT, et al. (2007). "Meta- and pooled analyses of the cytochrome P-450 1B1 Val432Leu polymorphism and breast cancer: a HuGE-GSEC review.". Am. J. Epidemiol. 165 (2): 115–25. doi:10.1093/aje/kwj365. PMID 17053044. 
• Coca-Prados M, Escribano J (2007). "New perspectives in aqueous humor secretion and in glaucoma: the ciliary body as a multifunctional neuroendocrine gland.". Progress in retinal and eye research 26 (3): 239–62. doi:10.1016/j.preteyeres.2007.01.002. PMID 17321191. 
• Sutter TR, Guzman K, Dold KM, Greenlee WF (1991). "Targets for dioxin: genes for plasminogen activator inhibitor-2 and interleukin-1 beta.". Science 254 (5030): 415–8. doi:10.1126/science.1925598. PMID 1925598. 
• Sutter TR, Tang YM, Hayes CL, et al. (1994). "Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2.". J. Biol. Chem. 269 (18): 13092–9. PMID 8175734. 
• Tang YM, Wo YY, Stewart J, et al. (1996). "Isolation and characterization of the human cytochrome P450 CYP1B1 gene.". J. Biol. Chem. 271 (45): 28324–30. doi:10.1074/jbc.271.45.28324. PMID 8910454. 
• Stoilov I, Akarsu AN, Sarfarazi M (1997). "Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21.". Hum. Mol. Genet. 6 (4): 641–7. doi:10.1093/hmg/6.4.641. PMID 9097971. 
• Bejjani BA, Lewis RA, Tomey KF, et al. (1998). "Mutations in CYP1B1, the gene for cytochrome P4501B1, are the predominant cause of primary congenital glaucoma in Saudi Arabia.". Am. J. Hum. Genet. 62 (2): 325–33. doi:10.1086/301725. PMC 1376900. PMID 9463332. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1376900. 
• Stoilov I, Akarsu AN, Alozie I, et al. (1998). "Sequence analysis and homology modeling suggest that primary congenital glaucoma on 2p21 results from mutations disrupting either the hinge region or the conserved core structures of cytochrome P4501B1.". Am. J. Hum. Genet. 62 (3): 573–84. doi:10.1086/301764. PMC 1376958. PMID 9497261. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1376958. 
• Bailey LR, Roodi N, Dupont WD, Parl FF (1998). "Association of cytochrome P450 1B1 (CYP1B1) polymorphism with steroid receptor status in breast cancer.". Cancer Res. 58 (22): 5038–41. PMID 9823305. 
• Plásilová M, Stoilov I, Sarfarazi M, et al. (1999). "Identification of a single ancestral CYP1B1 mutation in Slovak Gypsies (Roms) affected with primary congenital glaucoma.". J. Med. Genet. 36 (4): 290–4. doi:10.1136/jmg.36.4.290. PMC 1734351. PMID 10227395. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1734351. 
• Lewis DF, Lake BG, George SG, et al. (2000). "Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6 and CYP1B1 based on sequence homology with CYP102.". Toxicology 139 (1-2): 53–79. doi:10.1016/S0300-483X(99)00098-0. PMID 10614688. 
• Vincent A, Billingsley G, Priston M, et al. (2001). "Phenotypic heterogeneity of CYP1B1: mutations in a patient with Peters' anomaly.". J. Med. Genet. 38 (5): 324–6. doi:10.1136/jmg.38.5.324. PMC 1734880. PMID 11403040. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1734880. 
• Bofinger DP, Feng L, Chi LH, et al. (2001). "Effect of TCDD exposure on CYP1A1 and CYP1B1 expression in explant cultures of human endometrium.". Toxicol. Sci. 62 (2): 299–314. doi:10.1093/toxsci/62.2.299. PMID 11452143. 
• Michels-Rautenstrauss KG, Mardin CY, Zenker M, et al. (2002). "Primary congenital glaucoma: three case reports on novel mutations and combinations of mutations in the GLC3A (CYP1B1) gene.". J. Glaucoma 10 (4): 354–7. doi:10.1097/00061198-200108000-00017. PMID 11558822. 
• Lai J, Vesprini D, Chu W, et al. (2002). "CYP gene polymorphisms and early menarche.". Mol. Genet. Metab. 74 (4): 449–57. doi:10.1006/mgme.2001.3260. PMID 11749050. 
• Vincent AL, Billingsley G, Buys Y, et al. (2002). "Digenic inheritance of early-onset glaucoma: CYP1B1, a potential modifier gene.". Am. J. Hum. Genet. 70 (2): 448–60. doi:10.1086/338709. PMC 384919. PMID 11774072. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=384919. 

External links

• MeSH cytochrome+P-450+CYP1B1
• MeSH CYP1B1+protein,+human
• GeneReview/NCBI/NIH/UW entry on Primary Congenital Glaucoma

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This enzyme-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Human proteins Enzyme stubs Cytochrome P450 Wikimedia Foundation. 2010. Игры ⚽ Нужен реферат? Kane Phillips Thomas P. O'Neill Jr. Tunnel Look at other dictionaries: CYP1B1 — Saltar a navegación, búsqueda CYP1B1 Identificadores Símbolo CYP1B1 Símbolos alt. CP1B; GLC3A Entrez 154 …   Wikipedia Español Benzopyrene — Chembox new Name = Benzopyrene ImageFile = Benzo a pyrene.svg ImageSize = 180px ImageName = Benzopyrene IUPACName = Benzo [a] pyrene Section1 = Chembox Identifiers CASNo=50 32 8 SMILES = c1cc2cc/cc3ccc4cc5ccccc5c1c4c23 Section2 = Chembox… …   Wikipedia Benzo(a)pyrene — The correct title of this article is Benzo[a]pyrene. The substitution or omission of any < > [ ] { } is due to technical restrictions. Benzo[a]pyrene …   Wikipedia Cytochrome P450 — Oxidase (CYP2C9) Identifiers Symbol p450 Pfam …   Wikipedia Aryl hydrocarbon receptor — AHR redirects here. For other uses, see Ahr (disambiguation). Aryl hydrocarbon receptor Identifiers Symbols AHR; External IDs …   Wikipedia Estradiol — Strukturformel Allgemeines Freiname Estradiol Andere Namen …   Deutsch Wikipedia Lung cancer — Classification and external resources Cross section of a human lung. The white area in the upper lobe is cancer; the black areas are discoloration due to smoking. ICD 10 C …   Wikipedia Polychlorinated biphenyl — PCBs redirects here. For printed circuit boards, see printed circuit board. Labelling transformers containing PCBs …   Wikipedia CYP1A1 — is a gene. It encodes a member of the cytochrome P450 superfamily of enzymes. It is primarily involved in xenobiotic and drug metabolism (one substrate of it is theophylline). It is inhibited by fluoroquinolones and macrolides; induced by… …   Wikipedia PITX2 — Paired like homeodomain transcription factor 2, also known as PITX2, is a human gene. PBB Summary section title = summary text = This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins.… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”