- CYP2C8
Cytochrome P4502C8 (abbreviated CYP2C8), a member of the
cytochrome P450 mixed-function oxidase system, is involved in the metabolism ofxenobiotic s in the body.CYP2C8 Ligands
See also
*
Cytochrome P450 oxidase References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Goldstein JA, de Morais SM |title=Biochemistry and molecular biology of the human CYP2C subfamily. |journal=Pharmacogenetics |volume=4 |issue= 6 |pages= 285–99 |year= 1995 |pmid= 7704034 |doi=
*cite journal | author=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129–65 |year= 1999 |pmid= 9890157 |doi=
*cite journal | author=García-Martín E, Martínez C, Ladero JM, Agúndez JA |title=Interethnic and intraethnic variability of CYP2C8 and CYP2C9 polymorphisms in healthy individuals. |journal=Molecular diagnosis & therapy |volume=10 |issue= 1 |pages= 29–40 |year= 2007 |pmid= 16646575 |doi=
*cite journal | author=Ged C, Beaune P |title=Isolation of the human cytochrome P-450 IIC8 gene: multiple glucocorticoid responsive elements in the 5' region. |journal=Biochim. Biophys. Acta |volume=1088 |issue= 3 |pages= 433–5 |year= 1991 |pmid= 1707679 |doi=
*cite journal | author=Romkes M, Faletto MB, Blaisdell JA, "et al." |title=Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily. |journal=Biochemistry |volume=30 |issue= 13 |pages= 3247–55 |year= 1991 |pmid= 2009263 |doi=
*cite journal | author=Kolyada AY |title=Sequence of a human liver cytochrome P-450 cDNA clone. |journal=Nucleic Acids Res. |volume=18 |issue= 18 |pages= 5550 |year= 1990 |pmid= 2216732 |doi=
*cite journal | author=Shephard EA, Phillips IR, Santisteban I, "et al." |title=Cloning, expression and chromosomal localization of a member of the human cytochrome P450IIC gene sub-family. |journal=Ann. Hum. Genet. |volume=53 |issue= Pt 1 |pages= 23–31 |year= 1989 |pmid= 2729895 |doi=
*cite journal | author=Ged C, Umbenhauer DR, Bellew TM, "et al." |title=Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase. |journal=Biochemistry |volume=27 |issue= 18 |pages= 6929–40 |year= 1989 |pmid= 3196692 |doi=
*cite journal | author=Okino ST, Quattrochi LC, Pendurthi UR, "et al." |title=Characterization of multiple human cytochrome P-450 1 cDNAs. The chromosomal localization of the gene and evidence for alternate RNA splicing. |journal=J. Biol. Chem. |volume=262 |issue= 33 |pages= 16072–9 |year= 1987 |pmid= 3500169 |doi=
*cite journal | author=Kimura S, Pastewka J, Gelboin HV, Gonzalez FJ |title=cDNA and amino acid sequences of two members of the human P450IIC gene subfamily. |journal=Nucleic Acids Res. |volume=15 |issue= 23 |pages= 10053–4 |year= 1988 |pmid= 3697070 |doi=
*cite journal | author=Zeldin DC, DuBois RN, Falck JR, Capdevila JH |title=Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform. |journal=Arch. Biochem. Biophys. |volume=322 |issue= 1 |pages= 76–86 |year= 1995 |pmid= 7574697 |doi= 10.1006/abbi.1995.1438
*cite journal | author=Inoue K, Inazawa J, Suzuki Y, "et al." |title=Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1. |journal=Jpn. J. Hum. Genet. |volume=39 |issue= 3 |pages= 337–43 |year= 1995 |pmid= 7841444 |doi=
*cite journal | author=Gray IC, Nobile C, Muresu R, "et al." |title=A 2.4-megabase physical map spanning the CYP2C gene cluster on chromosome 10q24. |journal=Genomics |volume=28 |issue= 2 |pages= 328–32 |year= 1996 |pmid= 8530044 |doi= 10.1006/geno.1995.1149
*cite journal | author=Wormhoudt LW, Ploemen JH, de Waziers I, "et al." |title=Inter-individual variability in the oxidation of 1,2-dibromoethane: use of heterologously expressed human cytochrome P450 and human liver microsomes. |journal=Chem. Biol. Interact. |volume=101 |issue= 3 |pages= 175–92 |year= 1996 |pmid= 8870687 |doi=
*cite journal | author=McFayden MC, Melvin WT, Murray GI |title=Regional distribution of individual forms of cytochrome P450 mRNA in normal adult human brain. |journal=Biochem. Pharmacol. |volume=55 |issue= 6 |pages= 825–30 |year= 1998 |pmid= 9586955 |doi=
*cite journal | author=Macé K, Bowman ED, Vautravers P, "et al." |title=Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues. |journal=Eur. J. Cancer |volume=34 |issue= 6 |pages= 914–20 |year= 1998 |pmid= 9797707 |doi=
*cite journal | author=Klose TS, Blaisdell JA, Goldstein JA |title=Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs. |journal=J. Biochem. Mol. Toxicol. |volume=13 |issue= 6 |pages= 289–95 |year= 1999 |pmid= 10487415 |doi=
*cite journal | author=Finta C, Zaphiropoulos PG |title=The human CYP2C locus: a prototype for intergenic and exon repetition splicing events. |journal=Genomics |volume=63 |issue= 3 |pages= 433–8 |year= 2000 |pmid= 10704292 |doi= 10.1006/geno.1999.6063PBB_Controls
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