CYP4B1

Cytochrome P450, family 4, subfamily B, polypeptide 1, also known as CYP4B1, is a human gene.cite web | title = Entrez Gene: CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1580| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined.cite web | title = Entrez Gene: CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1580| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Windmill KF, McKinnon RA, Zhu X, "et al." |title=The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies. |journal=Mutat. Res. |volume=376 |issue= 1-2 |pages= 153–60 |year= 1997 |pmid= 9202751 |doi=
*cite journal | author=Hakkola J, Pelkonen O, Pasanen M, Raunio H |title=Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: role in intrauterine toxicity. |journal=Crit. Rev. Toxicol. |volume=28 |issue= 1 |pages= 35–72 |year= 1998 |pmid= 9493761 |doi=
*cite journal | author=Yokotani N, Sogawa K, Matsubara S, "et al." |title=cDNA cloning of cytochrome P-450 related to P-450p-2 from the cDNA library of human placenta. Gene structure and expression. |journal=Eur. J. Biochem. |volume=187 |issue= 1 |pages= 23–9 |year= 1990 |pmid= 2298205 |doi=
*cite journal | author=Nhamburo PT, Gonzalez FJ, McBride OW, "et al." |title=Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping. |journal=Biochemistry |volume=28 |issue= 20 |pages= 8060–6 |year= 1990 |pmid= 2574990 |doi=
*cite journal | author=McKinnon RA, Burgess WM, Gonzalez FJ, "et al." |title=Species-specific expression of CYP4B1 in rabbit and human gastrointestinal tissues. |journal=Pharmacogenetics |volume=4 |issue= 5 |pages= 260–70 |year= 1995 |pmid= 7894498 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Czerwinski M, McLemore TL, Gelboin HV, Gonzalez FJ |title=Quantification of CYP2B7, CYP4B1, and CYPOR messenger RNAs in normal human lung and lung tumors. |journal=Cancer Res. |volume=54 |issue= 4 |pages= 1085–91 |year= 1994 |pmid= 8313365 |doi=
*cite journal | author=Hakkola J, Raunio H, Purkunen R, "et al." |title=Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy. |journal=Biochem. Pharmacol. |volume=52 |issue= 2 |pages= 379–83 |year= 1996 |pmid= 8694864 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Hukkanen J, Hakkola J, Anttila S, "et al." |title=Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes. |journal=Mol. Carcinog. |volume=20 |issue= 2 |pages= 224–30 |year= 1997 |pmid= 9364212 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Hukkanen J, Mäntylä M, Kangas L, "et al." |title=Expression of cytochrome P450 genes encoding enzymes active in the metabolism of tamoxifen in human uterine endometrium. |journal=Pharmacol. Toxicol. |volume=82 |issue= 2 |pages= 93–7 |year= 1998 |pmid= 9498238 |doi=
*cite journal | author=Thum T, Borlak J |title=Gene expression in distinct regions of the heart. |journal=Lancet |volume=355 |issue= 9208 |pages= 979–83 |year= 2000 |pmid= 10768437 |doi=
*cite journal | author=Imaoka S, Yoneda Y, Sugimoto T, "et al." |title=CYP4B1 is a possible risk factor for bladder cancer in humans. |journal=Biochem. Biophys. Res. Commun. |volume=277 |issue= 3 |pages= 776–80 |year= 2000 |pmid= 11062028 |doi= 10.1006/bbrc.2000.3740
*cite journal | author=Henne KR, Kunze KL, Zheng YM, "et al." |title=Covalent linkage of prosthetic heme to CYP4 family P450 enzymes. |journal=Biochemistry |volume=40 |issue= 43 |pages= 12925–31 |year= 2001 |pmid= 11669629 |doi=
*cite journal | author=Finnström N, Bjelfman C, Söderström TG, "et al." |title=Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR. |journal=Eur. J. Clin. Invest. |volume=31 |issue= 10 |pages= 880–6 |year= 2002 |pmid= 11737226 |doi=
*cite journal | author=Iscan M, Klaavuniemi T, Coban T, "et al." |title=The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue. |journal=Breast Cancer Res. Treat. |volume=70 |issue= 1 |pages= 47–54 |year= 2002 |pmid= 11767004 |doi=
*cite journal | author=Lo-Guidice JM, Allorge D, Cauffiez C, "et al." |title=Genetic polymorphism of the human cytochrome P450 CYP4B1: evidence for a non-functional allelic variant. |journal=Pharmacogenetics |volume=12 |issue= 5 |pages= 367–74 |year= 2003 |pmid= 12142726 |doi=

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