Cefditoren

Cefditoren: Cefditoren

Systematic (IUPAC) name

(7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-((Z)-2-(4-methylthiazol-5-yl)vinyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Clinical data

Trade names Spectracef

AHFS/Drugs.com monograph

MedlinePlus a605003

Pregnancy cat. ?

Legal status ?

Identifiers

CAS number 104145-95-1^N

ATC code J01DD16

PubChem CID 9870843

ChemSpider 8046534^Y

UNII 81QS09V3YW^Y

KEGG D07639^N

ChEBI CHEBI:59343^Y

Chemical data

Formula C₁₉H₁₈N₆O₅S₃

Mol. mass 506.58 g/mol

SMILES eMolecules & PubChem

InChI

InChI=1S/C19H18N6O5S3/c1-8-11(33-7-21-8)4-3-9-5-31-17-13(16(27)25(17)14(9)18(28)29)23-15(26)12(24-30-2)10-6-32-19(20)22-10/h3-4,6-7,13,17H,5H2,1-2H3,(H2,20,22)(H,23,26)(H,28,29)/b4-3-,24-12-/t13-,17-/m1/s1^Y
Key:KMIPKYQIOVAHOP-YLGJWRNMSA-N^Y

N(what is this?) (verify)

Cefditoren is a third-generation cephalosporin antibiotic for oral use. It is commonly marketed under the trade name Spectracef by Cornerstone BioPharma.

Cefditoren is also marketed under the name Meiact.^[1]

Contents

1 Clinical use

1.1 Indications

1.2 Formulations

2 References

3 External links

Clinical use

Main article: Cephalosporin

Indications

Cefditoren is used to treat uncomplicated skin and skin structure infections, community-acquired pneumonia, acute bacterial exacerbation of chronic bronchitis (ABECB), pharyngitis, and tonsillitis.

Formulations

Cefditoren is available as 200 and 400 mg tablets. It can be formulated as the prodrug cefditoren pivoxil.

Chemical structure of cefditoren pivoxil

References

^ Meiact Full Description

External links

Manufacturer's Product website

Manufacturer's prescribing information for Spectracef

v · d · eAntibacterials: cell envelope antibiotics (J01C-J01D)

Intracellular
inhibit peptidoglycan subunit synthesis and transport: NAM synthesis inhibition (Fosfomycin) • DADAL/AR inhibitors (Cycloserine) • bactoprenol inhibitors (Bacitracin)

Glycopeptide
inhibit PG chain elongation: Vancomycin^# (Oritavancin, Telavancin) • Teicoplanin (Dalbavancin) • Ramoplanin

β-lactams/
(inhibit PBP
cross-links)

Penicillins/
(penams)

Extended sp.

aminopenicillins: Amoxicillin^# • Ampicillin^# (Pivampicillin, Hetacillin, Bacampicillin, Metampicillin, Talampicillin) • Epicillin

carboxypenicillins: Carbenicillin (Carindacillin) • Ticarcillin • Temocillin

ureidopenicillins: Azlocillin • Piperacillin • Mezlocillin
other: Mecillinam (Pivmecillinam) • Sulbenicillin

Narrow sp.

β-lactamase sensitive

Benzylpenicillin (G)^#: Clometocillin • Benzathine benzylpenicillin^# • Procaine benzylpenicillin^# • Azidocillin • Penamecillin
Phenoxymethylpenicillin (V)^#: Propicillin • Benzathine phenoxymethylpenicillin • Pheneticillin

β-lactamase resistant

Cloxacillin^# (Dicloxacillin, Flucloxacillin) • Oxacillin • Meticillin • Nafcillin

Penems

Faropenem

Carbapenems

Biapenem • Ertapenem • antipseudomonal (Doripenem • Imipenem • Meropenem) • Panipenem

Cephalosporins/
(cephems)

1st (P Ec K)

Cefazolin^# • Cefacetrile • Cefadroxil • Cefalexin • Cefaloglycin • Cefalonium • Cefaloridine • Cefalotin • Cefapirin • Cefatrizine • Cefazedone • Cefazaflur • Cefradine • Cefroxadine • Ceftezole

2nd (H E N)

Cefaclor • Cefamandole • Cefminox • Cefonicid • Ceforanide • Cefotiam • Cefprozil • Cefbuperazone • Cefuroxime • Cefuzonam • cephamycin (Cefoxitin, Cefotetan, Cefmetazole) • carbacephem (Loracarbef)

3rd

Cefixime^# • Ceftriaxone^# • antipseudomonal (Ceftazidime^# • Cefoperazone) • Cefcapene • Cefdaloxime • Cefdinir • Cefditoren • Cefetamet • Cefmenoxime • Cefodizime • Cefotaxime • Cefpimizole • Cefpiramide • Cefpodoxime • Cefsulodin • Cefteram • Ceftibuten • Ceftiolene • Ceftizoxime • oxacephem (Flomoxef, Latamoxef ^‡)

4th (antips-)

Cefepime • Cefozopran • Cefpirome • Cefquinome

5th

Ceftobiprole • Ceftaroline fosamil

Veterinary

Ceftiofur • Cefquinome • Cefovecin

Monobactams

Aztreonam • Tigemonam • Carumonam • Tabtoxin

β-lactamase inh.

penam (Sulbactam, Tazobactam) • clavam (Clavulanic acid)

Combinations

Amoxicillin/clavulanic acid^# • Imipenem/cilastatin^# • Ampicillin/flucloxacillin • Ampicillin/sulbactam (Sultamicillin) • Piperacillin/tazobactam

Other
polymyxins/detergent (Colistin, Polymyxin B) • depolarizing (Daptomycin) • hydrolyze NAM-NAG (Lysozyme) • Gramicidin

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: BAC

bact (clas)

gr+f/gr+a(t)/gr-p(c)/gr-o

drug(J1p, w, n, m, vacc)

Categories:
Cephalosporin antibiotics
Thiazoles

Cefditoren

Systematic (IUPAC) name
(7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-((Z)-2-(4-methylthiazol-5-yl)vinyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Clinical data
Trade names	Spectracef
AHFS/Drugs.com	monograph
MedlinePlus	a605003
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	104145-95-1^N
ATC code	J01DD16
PubChem	CID 9870843
ChemSpider	8046534^Y
UNII	81QS09V3YW^Y
KEGG	D07639^N
ChEBI	CHEBI:59343^Y
Chemical data
Formula	C₁₉H₁₈N₆O₅S₃
Mol. mass	506.58 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C19H18N6O5S3/c1-8-11(33-7-21-8)4-3-9-5-31-17-13(16(27)25(17)14(9)18(28)29)23-15(26)12(24-30-2)10-6-32-19(20)22-10/h3-4,6-7,13,17H,5H2,1-2H3,(H2,20,22)(H,23,26)(H,28,29)/b4-3-,24-12-/t13-,17-/m1/s1^Y Key:KMIPKYQIOVAHOP-YLGJWRNMSA-N^Y
N(what is this?) (verify)

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

cefditoren — noun A particular third generation cephalosporin antibiotic for oral use … Wiktionary
cefditoren pivoxil — cef·di·tor·en pi·vox·il (sef″dĭ torґən) a third generation cephalosporin antibiotic active against a wide range of bacteria, used for infections of the respiratory tract or skin … Medical dictionary
Cephalosporin — See also: Discovery and development of cephalosporins Core structure of the cephalosporins … Wikipedia
Pivmecillinam — Systematic (IUPAC) name 2,2 dimethylpropanoyloxymethyl (2S,5R,6R) 6 [(azepan 1 ylmethylene)amino] 3,3 dimethyl 7 oxo 4 thia 1 azabicyclo[3.2.0]heptane 2 carboxylate Cli … Wikipedia
Ampicillin — Systematic (IUPAC) name (2S,5R,6R) 6 ([(2R) 2 amino 2 phenylace … Wikipedia
Amoxicillin — Systematic (IUPAC) name (2S,5R,6R) 6 … Wikipedia
Penicillin — For the Japanese band, see Penicillin (band). Penicillin core structure. The R is the variable group. Penicillin (sometimes abbreviated PCN or pen) is a group of antibiotics derived from Penicillium fungi.[1] They include … Wikipedia
Meticillin — Systematic (IUPAC) name (2S,5R,6R) 6 [(2,6 dimethoxybenzoyl)amino] 3,3 dimethyl 7 oxo 4 thia 1 azabicyclo[3.2.0]heptane 2 carboxylic acid Clinical data … Wikipedia
Lysozyme — single crystal Identifiers EC number 3.2.1.17 … Wikipedia
Isoniazid — Systematic (IUPAC) name isonicotinohydrazide … Wikipedia

Academic Dictionaries and Encyclopedias

Cefditoren

Contents

Clinical use

Indications

Formulations

References

External links

Look at other dictionaries:

Share the article and excerpts

Academic Dictionaries and Encyclopedias

Wikipedia

Cefditoren

Contents

Clinical use

Indications

Formulations

References

External links

Look at other dictionaries:

Share the article and excerpts

Direct link