Cefprozil

Cefprozil

Systematic (IUPAC) name
7-[2-amino-2-(4-hydroxyphenyl)-acetyl]amino-8-oxo-3-prop-1-enyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Clinical data
Trade names	Cefzil
AHFS/Drugs.com	monograph
MedlinePlus	a698022
Licence data	US FDA:link
Pregnancy cat.	B(US)
Legal status	℞-only (US)
Routes	Oral
Pharmacokinetic data
Bioavailability	95%
Protein binding	36%
Half-life	1.3 hours
Identifiers
CAS number	92665-29-7 Y
ATC code	J01DC10
PubChem	CID 9887643
DrugBank	APRD00461
ChemSpider	8063315 Y
UNII	1M698F4H4E Y
KEGG	D07651 Y
ChEMBL	CHEMBL1742 N
Chemical data
Formula	C18H19N3O5S
Mol. mass	389.427 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C18H19N3O5S.H2O/c1-2-3-10-8-27-17-13(16(24)21(17)14(10)18(25)26)20-15(23)12(19)9-4-6-11(22)7-5-9;/h2-7,12-13,17,22H,8,19H2,1H3,(H,20,23)(H,25,26);1H2/b3-2-;/t12-,13-,17-;/m1./s1 Y Key:ALYUMNAHLSSTOU-HERYOFLYSA-N Y
N(what is this?)  (verify)

Cefprozil, sometimes spelled cefproxil and marketed under the trade name Cefzil, is a second-generation cephalosporin type antibiotic. In Europe it is marketed using the trade names Procef and Cronocef.^{[citation needed]} It can be used to treat bronchitis, ear infections, skin infections, and other bacterial infections.^{[citation needed]} It comes as a tablet and as a liquid suspension.

Although there is a widely quoted cross-allergy risk of 10% between cephalosporins and penicillin, an article in the Journal of Family Practice^[1] has shown no increased risk for cross-allergy for cefprozil and several other second-generation or later cephalosporins.

References

1. ^ Pichichero, ME (February 2006). "Cephalosporins can be prescribed safely for penicillin-allergic patients". J Fam Pract 55 (2): 106–12. PMID 16451776. http://www.jfponline.com/pdf%2F5502%2F5502JFP%5FAppliedEvidence1%2Epdf. 

External links

• Cefprozil MedlinePlus Drug Information

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