Ramoplanin

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CAS_number = 76168-82-6
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PubChem = 16132338
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C=106 | H=170 | Cl=1 | N=21 | O=30
molecular_weight = 2254.05 g/mol
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legal_US = Rx-only
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routes_of_administration = Oral

Ramoplanin (INN) is a glycolipodepsipeptide antibiotic drug derived from strain ATCC 33076 of "Actinoplanes". [Farver DK, Hedge DD, Lee SC. Ramoplanin: a lipoglycodepsipeptide antibiotic. "Annals of Pharmacotherapy". 2005 May;39(5):863-8. PMID 15784805] It exerts its bacteriocidal effect by inhibiting cell wall biosynthesis, acting by inhibiting the transglycosylation step of peptidoglycan synthesis. [Fang X, Tiyanont K, Zhang Y, Wanner J, Boger D, Walker S. The mechanism of action of ramoplanin and enduracidin. "Molecular Biosystems". 2006 Jan;2(1):69-76. PMID 16880924] Its development has been fast tracked by the FDA as a treatment for multi-antibiotic resistant "Clostridium difficile" infection of the gastrointestinal tract, [Fulco P, Wenzel RP. Ramoplanin: a topical lipoglycodepsipeptide antibacterial agent. "Expert Review of Anti Infective Therapy". 2006 Dec;4(6):939-45. PMID 17181409] although it is unstable in the bloodstream and so can only be taken orally against GI tract infections. [Scheinfeld N. A comparison of available and investigational antibiotics for complicated skin infections and treatment-resistant Staphylococcus aureus and enterococcus. "Journal of Drugs in Dermatology". 2007 Jan;6(1):97-103. PMID 17373167] [Balagopal A, Sears CL. Clostridium difficile: new therapeutic options. "Current Opinion in Pharmacology". 2007 Oct;7(5):455-8. PMID 17644040] [Gerding DN, Muto CA, Owens RC Jr. Treatment of Clostridium difficile infection. "Clinical Infectious Diseases". 2008 Jan 15;46 Suppl 1:S32-42. PMID 18177219]

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