Ureidopenicillin

Ureidopenicillin

The ureidopenicillins are a group of penicillins which are active against "Pseudomonas aeruginosa". There are three ureidopenicillins in clinical use:
*Azlocillin
*Piperacillin
*Mezlocillin

They are mostly ampicillin derivatives in which the D-side amino chain has been converted to a variety of ureas. It is speculated that the added side chain mimics a longer segment of the peptidoglycan chain, more than ampicillin, and thus would bind more easily to the penicillin-binding proteins. Ureidopenicillins are not resistant to beta-lactamases.

They are used parenterally, and are particularly indicated in infections caused by Gram-negative bacteria.


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  • ureidopenicillin — noun Any of a class of penicillin antibiotics in which an amino group has been replaced by a urea moiety …   Wiktionary

  • ureidopenicillin — ure·id·o·pen·i·cil·lin (u re″ĭ do pen″ĭ silґin) [ureide + penicillin] any in a group of penicillin derivatives in which a urea has replaced an amino side chain …   Medical dictionary

  • Piperacillin — drugbox IUPAC name = (2 S ,5 R ,6 R ) 6 { [(2 R ) 2 [(4 ethyl 2,3 dioxo piperazine 1 carbonyl)amino] 2 phenyl acetyl] amino} 3,3 dimethyl 7 oxo 4 thia 1 azabicyclo [3.2.0] heptane 2 carboxylic acid CAS number = 66258 76 2 ATC prefix = J01 ATC… …   Wikipedia

  • Piperacillin/tazobactam — Drugbox type = combo component1 = Piperacillin class1 = Ureidopenicillin antibiotic component2 = Tazobactam class2 = Beta lactamase inhibitor CAS number = 123683 33 0 ATC prefix = J01 ATC suffix = CR05 PubChem = 153901 DrugBank = pregnancy AU =… …   Wikipedia

  • Ventilator-associated pneumonia — (VAP) is a sub type of hospital acquired pneumonia (HAP) which occurs in people who are on mechanical ventilation through an endotracheal or tracheostomy tube for at least 48 hours. VAP is a medical condition that results from infection which… …   Wikipedia

  • piperacillin — noun A particular ureidopenicillin antibiotic …   Wiktionary

  • mezlocillin sodium — C21H24NaN5O8S2; an extended spectrum penicillin antibiotic used intravenously and intramuscularly. * * * mez·lo·cil·lin so·di·um (mez″lo silґin) [USP] a semisynthetic, broad spectrum penicillin of the ureidopenicillin group, effective… …   Medical dictionary

  • azlocillin — az·lo·cil·lin (az″lo silґin) a broad spectrum penicillin of the ureidopenicillin group, effective against a wide variety of gram positive and gram negative organisms but used primarily in the treatment of Pseudomonas aeruginosa infections;… …   Medical dictionary

  • piperacillin — pi·per·a·cil·lin (pi perґə sil″in) [USP] a semisynthetic broad spectrum penicillin of the ureidopenicillin group, effective against a wide variety of gram positive and gram negative aerobic and anaerobic bacteria …   Medical dictionary

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