Cefoxitin

Cefoxitin

Systematic (IUPAC) name
(6S,7R)-4-(carbamoyloxymethyl)-7-methoxy- 8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia- 1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Clinical data
Trade names	Mefoxin
AHFS/Drugs.com	monograph
MedlinePlus	a682737
Pregnancy cat.	B
Legal status	?
Routes	IV
Pharmacokinetic data
Metabolism	minimal
Half-life	41-59 min
Excretion	85% urine
Identifiers
CAS number	35607-66-0 Y
ATC code	J01DC01
PubChem	CID 441199
DrugBank	DB01331
ChemSpider	389981 Y
UNII	6OEV9DX57Y Y
KEGG	D02345 N
ChEBI	CHEBI:209807 N
ChEMBL	CHEMBL996 N
Chemical data
Formula	C16H17N3O7S2
Mol. mass	427.454 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C16H17N3O7S2/c1-25-16(18-10(20)5-9-3-2-4-27-9)13(23)19-11(12(21)22)8(6-26-15(17)24)7-28-14(16)19/h2-4,14H,5-7H2,1H3,(H2,17,24)(H,18,20)(H,21,22)/t14-,16+/m1/s1 Y Key:WZOZEZRFJCJXNZ-ZBFHGGJFSA-N Y
N(what is this?)  (verify)

Cefoxitin is a cephamycin antibiotic developed by Merck & Co., Inc., often grouped with the second−generation cephalosporins. It is sold under the brand name Mefoxin.

Microbiology

Cefoxitin acts by interfering with cell wall synthesis. Its activity spectrum includes a broad range of gram-negative and gram-positive bacteria including anaerobes. It is inactive in vitro to most strains of Pseudomonas aeruginosa and enterococci and many strains of Enterobacter cloacae. Staphylococci resistant to methicillin/oxacillin should be considered resistant to cefoxitin. ^[1]

Cefoxitin is considered a strong beta-lactamase inducer, as are certain other antibiotics (such as imipenem).^[2]

References

1. ^ Mefoxin Official FDA information at Drugs.com
2. ^ Phillips I, Shannon K (1993). "Importance of beta-lactamase induction". Eur J Clin Microbiol Infect Dis 12 Suppl 1: S19–26. PMID 8477758. 

This systemic antibacterial-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Cephalosporin antibiotics Thiazoles Antibiotic stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? Herb Pearson Hip Hip Hooray (EP) Look at other dictionaries: Cefoxitin — См. Цефокситин (Источник: «Словарь терминов микробиологии») …   Словарь микробиологии cefoxitin sodium — A semisynthetic antibiotic derived from cephamycin C, but structurally and pharmacologically similar to the cephalosporins; used by injection. * * * [USP] the monosodium salt of cefoxitin, used to treat infections caused by susceptible organisms; …   Medical dictionary Cefoxitin — ЦЕФОКСИТИН ( Сеfохitin )*. (7S) 3 [(Карбамоилокси)метил] 7 метокси 7 (2 тиенилацетамидо) 3 цефем 4 карбоновая кислота. Синонимы: Мефоксин (название препарата фирмы МЕRCK & СО., INC. , Rahway N. J., U.S.А.), Аtralxitin, Веtасеf, Воnсеfin, Сеfосtin …   Словарь медицинских препаратов cefoxitin — /seuh fok si tin/, n. Pharm. a broad spectrum, crystalline, semisynthetic cephalosporin antibiotic, C16H17N3O7, used in the treatment of serious infections caused by susceptible Gram positive and Gram negative bacteria. [cef (see CEFACLOR) + OX + …   Universalium cefoxitin — noun A particular cephalosporin antibiotic …   Wiktionary cefoxitin — ce·fox·i·tin si fäk sət ən n a semisynthetic cephamycin antibiotic that is administered parenterally in the form of its sodium salt C16H16N3NaO7S2 * * * ce·fox·i·tin (sə fokґsĭ tin) a cephamycin antibiotic derived from cephamycin C and… …   Medical dictionary cefoxitin — /seuh fok si tin/, n. Pharm. a broad spectrum, crystalline, semisynthetic cephalosporin antibiotic, C16H17N3O7, used in the treatment of serious infections caused by susceptible Gram positive and Gram negative bacteria. [cef (see CEFACLOR) + OX + …   Useful english dictionary cycloserine-cefoxitin-fructose–egg yolk agar — an agar medium containing peptone, sodium chloride, magnesium sulfate, fructose, neutral red, and phosphate buffer, supplemented with cycloserine, cefoxitin, and egg yolk, used as a selective medium for Clostridium difficile …   Medical dictionary Cephamycin — Cefoxitin Cefotetan …   Wikipedia CFX — cefoxitin; circumflex coronary artery …   Medical dictionary 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”