Tazobactam

Tazobactam

drugbox
IUPAC_name = (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4$l^{6}-thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid


CAS_number = 89786-04-9
ATC_prefix = J01
ATC_suffix = CG02
ATC_supplemental =
PubChem =
DrugBank = EXPT03012
C=10 | H=12 | N=4 | O=5 | S=1
molecular_weight = 300.289 g/mol
bioavailability =
protein_bound =
metabolism =
elimination_half-life =
pregnancy_category =
legal_status =
routes_of_administration =

Tazobactam is a compound which inhibits the action of bacterial beta-lactamases. It is added to the extended spectrum beta-lactam antibiotic piperacillin to produce Tazocin or Zosyn. It broadens the spectrum of piperacillin by making it effective against organisms that express beta-lactamase and would normally degrade piperacillin.

Tazobactam sodium is a derivative of the penicillin nucleus and is a penicillanic acid sulfone.

External links

* [http://www.zosyn.com Zosyn (piperacillin / tazobactam)]


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  • Tazobactam — Strukturformel Allgemeines Freiname Tazobactam Andere Namen …   Deutsch Wikipedia

  • tazobactam sodium — the sodium salt of tazobactam, used in combination with piperacillin sodium to broaden its spectrum of activity against beta lactamase–producing organisms …   Medical dictionary

  • tazobactam — noun A compound that inhibits the action of bacterial beta lactamases, used in antibiotics …   Wiktionary

  • tazobactam — taz·o·bac·tam (taz″o bakґtam) a penicillanic acid sulfone derivative similar to sulbactam that acts as a beta lactamase inhibitor …   Medical dictionary

  • Piperacillin/tazobactam — Drugbox type = combo component1 = Piperacillin class1 = Ureidopenicillin antibiotic component2 = Tazobactam class2 = Beta lactamase inhibitor CAS number = 123683 33 0 ATC prefix = J01 ATC suffix = CR05 PubChem = 153901 DrugBank = pregnancy AU =… …   Wikipedia

  • piperacillin-tazobactam — A drug combination that is used to treat infection in people with cancer. Piperacillin is a synthetic penicillin; tazobactam enhances the effectiveness of piperacillin …   English dictionary of cancer terms

  • Beta-lactamase — Beta lactamases are enzymes (EC number|3.5.2.6) produced by some bacteria and are responsible for their resistance to beta lactam antibiotics like penicillins, cephalosporins, cephamycins, ertapenems and carbapenems. These antibiotics have a… …   Wikipedia

  • Piperacillin — drugbox IUPAC name = (2 S ,5 R ,6 R ) 6 { [(2 R ) 2 [(4 ethyl 2,3 dioxo piperazine 1 carbonyl)amino] 2 phenyl acetyl] amino} 3,3 dimethyl 7 oxo 4 thia 1 azabicyclo [3.2.0] heptane 2 carboxylic acid CAS number = 66258 76 2 ATC prefix = J01 ATC… …   Wikipedia

  • Piperacilina — Saltar a navegación, búsqueda Piperacilina …   Wikipedia Español

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