Peptidoglycan glycosyltransferase
- Peptidoglycan glycosyltransferase
In enzymology, a peptidoglycan glycosyltransferase (EC number|2.4.1.129) is an enzyme that catalyzes the chemical reaction
: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)] n- diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)- diphosphoundecaprenol [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)] n+1- diphosphoundecaprenol + undecaprenyl diphosphate
The 4 substrates of this enzyme are [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)] n-, diphosphoundecaprenol, GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-, and diphosphoundecaprenol, whereas its 3 products are [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)] n+1-, diphosphoundecaprenol, and undecaprenyl diphosphate.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-mu ramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-( 1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase. Other names in common use include PG-II, bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-, pentapeptide:peptidoglycan, N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase, penicillin binding protein (3 or 1B), and peptidoglycan transglycosylase. This enzyme participates in peptidoglycan biosynthesis.
tructural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2BG1, PDB link|2UWX, and PDB link|2UWY.
References
*
*
*
External links
::"The CAS registry number for this enzyme class is CAS registry|79079-04-2."
Gene Ontology (GO) codes
Wikimedia Foundation.
2010.
Look at other dictionaries:
Glycosyltransferase — [ PDB3|1f0k). Blue plane shows hydrocarbon boundary of the lipid bilayer] Glycosyltransferases are enzymes (EC 2.4) that act as a catalyst for the transfer of a monosaccharide unit from an activated sugar phosphate (known as the glycosyl donor )… … Wikipedia
List of EC numbers (EC 2) — This list contains a list of EC numbers for the second group, EC 2, transferases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 2.1: Transferring One… … Wikipedia
ChGn — Chondroitin sulfate N acetylgalactosaminyltransferase 1 Identifiers Symbols CSGALNACT1; CSGalNAcT 1; ChGn; FLJ11264; FLJ13760; beta4GalNAcT External IDs … Wikipedia
Glycans — The term glycan refers to a polysaccharide or oligosaccharide. Glycan may also be used to refer to the carbohydrate portion of a glycoconjugate, such as a glycoprotein, glycolipid, or a proteoglycan. Glycans usually consist solely of O glycosidic … Wikipedia
Glycan — Not to be confused with glucan. The term glycan refers to a polysaccharide or oligosaccharide. Glycans usually consist solely of O glycosidic linkages of monosaccharides. For example, cellulose is a glycan (or, to be more specific, a glucan)… … Wikipedia
Glycogen — is a polysaccharide of glucose (Glc) which functions as the secondary short term energy storage in animal cells. It is made primarily by the liver and the muscles, but can also be made by the brain, uterus, and the vagina. [Anatomy and Physiology … Wikipedia
Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase — In enzymology, an undecaprenyldiphospho muramoylpentapeptide beta N acetylglucosaminyltransferase (EC number|2.4.1.227) is an enzyme that catalyzes the chemical reaction:UDP N acetylglucosamine + Mur2Ac(oyl L Ala gamma D Glu L Lys D Ala D Ala)… … Wikipedia
