ChGn

Chondroitin sulfate N-acetylgalactosaminyltransferase 1
Identifiers
Symbols	CSGALNACT1; CSGalNAcT-1; ChGn; FLJ11264; FLJ13760; beta4GalNAcT
External IDs	MGI: 2442354 HomoloGene: 23099 GeneCards: CSGALNACT1 Gene
EC number	2.4.1.174
Gene Ontology Molecular function • acetylgalactosaminyltransferase activity • acetylgalactosaminyltransferase activity • peptidoglycan glycosyltransferase activity • glucuronosyltransferase activity • transferase activity • metal ion binding • glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity • glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity Cellular component • intracellular • soluble fraction • Golgi apparatus • membrane • integral to membrane • integral to Golgi membrane • Golgi cisterna membrane Biological process • nervous system development • cell recognition • cell proliferation • anatomical structure morphogenesis • heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process • UDP-N-acetylgalactosamine metabolic process • proteoglycan biosynthetic process • extracellular matrix organization • chondroitin sulfate biosynthetic process • heparin biosynthetic process • UDP-glucuronate metabolic process • chondroitin sulfate proteoglycan biosynthetic process • dermatan sulfate proteoglycan biosynthetic process • chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55790	234356
Ensembl	ENSG00000147408	ENSMUSG00000036356
UniProt	Q8TDX6	Q3UNQ5
RefSeq (mRNA)	NM_001130518.1	NM_172753.4
RefSeq (protein)	NP_001123990.1	NP_766341.4
Location (UCSC)	Chr 8: 19.26 – 19.62 Mb	Chr 8: 70.88 – 71.26 Mb
PubMed search	[1]	[2]

Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the CSGALNACT1 gene.^[1][2][3]

References

1. ^ Sakai K, Kimata K, Sato T, Gotoh M, Narimatsu H, Shinomiya K, Watanabe H (Feb 2007). "Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage". J Biol Chem 282 (6): 4152–61. doi:10.1074/jbc.M606870200. PMID 17145758. 
2. ^ Sato T, Gotoh M, Kiyohara K, Akashima T, Iwasaki H, Kameyama A, Mochizuki H, Yada T, Inaba N, Togayachi A, Kudo T, Asada M, Watanabe H, Imamura T, Kimata K, Narimatsu H (Jan 2003). "Differential roles of two N-acetylgalactosaminyltransferases, CSGalNAcT-1, and a novel enzyme, CSGalNAcT-2. Initiation and elongation in synthesis of chondroitin sulfate". J Biol Chem 278 (5): 3063–71. doi:10.1074/jbc.M208886200. PMID 12446672. 
3. ^ "Entrez Gene: ChGn chondroitin beta1,4 N-acetylgalactosaminyltransferase". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55790. 

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gotoh M, Sato T, Akashima T, et al. (2002). "Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis.". J. Biol. Chem. 277 (41): 38189–96. doi:10.1074/jbc.M203619200. PMID 12163485. 
• Uyama T, Kitagawa H, Tamura Ji J, Sugahara K (2002). "Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate.". J. Biol. Chem. 277 (11): 8841–6. doi:10.1074/jbc.M111434200. PMID 11788602. 
• Kitagawa H, Uyama T, Sugahara K (2001). "Molecular cloning and expression of a human chondroitin synthase.". J. Biol. Chem. 276 (42): 38721–6. doi:10.1074/jbc.M106871200. PMID 11514575.