Cefadroxil

Cefadroxil
Cefadroxil
Systematic (IUPAC) name
(6R,7R)-7-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Clinical data
Trade names Duricef
AHFS/Drugs.com monograph
MedlinePlus a682730
Pregnancy cat.  ?
Legal status  ?
Routes Oral
Pharmacokinetic data
Protein binding plasma protein
Metabolism unknown
Half-life 1.5 hours
Identifiers
CAS number 66592-87-8 YesY
ATC code J01DB05
PubChem CID 47964
DrugBank APRD00196
ChemSpider 43629 YesY
UNII 280111G160 YesY
KEGG D02353 YesY
ChEBI CHEBI:53667 YesY
ChEMBL CHEMBL1644 N
Chemical data
Formula C16H17N3O5S 
Mol. mass 363.389 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Cefadroxil is a broad-spectrum antibiotic of the cephalosporin type, effective in Gram-positive and Gram-negative bacterial infections. It is a bactericidal antibiotic.

Contents

General use

Cefadroxil is a first-generation cephalosporin antibacterial drug that is the para-hydroxy derivative of cefalexin, and is used similarly in the treatment of mild to moderate susceptible infections such as the bacterium Streptococcus pyogenes, causing the disease popularly called strep throat or Streptococcal tonsillitis, urinary tract infection, reproductive tract infection and skin infections.

Pharmacokinetics

Cefadroxil is almost completely absorbed from the gastrointestinal tract. After doses of 500 mg and 1 g by mouth, peak plasma concentrations of about 16 and 30 micrograms/mL respectively are obtained after 1.5 to 2 hours. Although peak concentrations are similar to those of cefalexin, plasma concentrations are more sustained. Dosage with food does not appear to affect the absorption of cefadroxil. About 20% of cefadroxil is reported to be bound to plasma proteins. The plasma half-life of cefadroxil is about 1.5 hours and is prolonged in patients with renal impairment.

Cefadroxil is widely distributed to body tissues and fluids. It crosses the placenta and appears in breast milk.

More than 90% of a dose of cefadroxil may be excreted unchanged in the urine within 24 hours by glomerular filtration and tubular secretion; peak urinary concentrations of 1.8 mg/mL have been reported after a dose of 500 mg. Cefadroxil is removed by haemodialysis.

Dosage

Cefadroxil is given by mouth, and doses are expressed in terms of the anhydrous substance; 1.04 g of cefadroxil monohydrate is equivalent to about 1 g of anhydrous cefadroxil.

Side effects

The most common side effects of Cefadroxil are diarrhoea (which, less commonly, may be bloody), nausea, upset stomach, and vomiting. Other side effects include[1]:

  • Rashes
  • Hives
  • Itching

Dental use

Cefadroxil is used as an antibiotic prophylaxis before dental procedures.

(Always consider Amoxicillin plus Metronidazole as first line of treatment for dental procedures. In Case of penicillin allergy consider "Cefadroxil" for prophylaxis.)[citation needed]

Veterinary use

Can be used for treating infected wounds on animals. Usually in powder form mixed with water has a color and smell similar to Tang. Given orally to animals, amount dependent on their weight and severity of infection.

References


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Look at other dictionaries:

  • Céfadroxil — Général Nom IUPAC acide 7β {[(2R) 2 amino 2 (4 hydroxyphényl)acétyl]amino} 2,3 didéhydrocépham 2 carboxylique S …   Wikipédia en Français

  • Cefadroxil — См. Цефадроксил (Источник: «Словарь терминов микробиологии») …   Словарь микробиологии

  • Cefadroxil — Strukturformeln klassischer Cephalosporine. Cephalosporine sind eine Gruppe von Breitband Antibiotika für den medizinischen Einsatz. Wie auch die Penicilline gehören sie der Gruppe der β Lactam Antibiotika an. Sie wirken bakterizid auf… …   Deutsch Wikipedia

  • cefadroxil monohidrato — Antibiótico del grupo de las cefalosporinas indicado en el tratamiento de ciertas infecciones bacterianas. Diccionario Mosby Medicina, Enfermería y Ciencias de la Salud, Ediciones Hancourt, S.A. 1999 …   Diccionario médico

  • cefadroxil — cef·a·drox·il (sĕf ə drŏkʹsəl) n. A semisynthetic analogue of cephalosporin, C16H17N3O3S, that is administered orally and has a broad spectrum of antibiotic activity.   [Alteration of cephalosporin + alteration of hydroxyl.] * * * …   Universalium

  • cefadroxil — noun A broad spectrum cephalosporin antibiotic …   Wiktionary

  • cefadroxil — A semisynthetic broad spectrum antibiotic derived from cephalosporin C; used orally. * * * n. a cephalosporin antibiotic used in the treatment of urinary tract infections, skin infections, pharyngitis, and tonsillitis. It is administered by… …   Medical dictionary

  • cefadroxil — n. a cephalosporin antibiotic used in the treatment of urinary tract infections, skin infections, pharyngitis, and tonsillitis. It is administered by mouth; side effects include skin rash and generalized itching. Trade names: Baxan …   The new mediacal dictionary

  • cefadroxil — noun a cephalosporin antibiotic (trade name Ultracef) • Syn: ↑Ultracef • Usage Domain: ↑trade name (for: ↑Ultracef) • Hypernyms: ↑cephalosporin, ↑Mefo …   Useful english dictionary

  • Cephalosporin — See also: Discovery and development of cephalosporins Core structure of the cephalosporins …   Wikipedia

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