D-alanine-D-alanine ligase

In enzymology, a D-alanine-D-alanine ligase (EC number|6.3.2.4) is an enzyme that catalyzes the chemical reaction

:ATP + 2 D-alanine $ightleftharpoons$ ADP + phosphate + D-alanyl-D-alanine

Thus, the two substrates of this enzyme are ATP and D-alanine, whereas its 3 products are ADP, phosphate, and D-alanyl-D-alanine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is D-alanine:D-alanine ligase (ADP-forming). Other names in common use include MurE synthetase [ambiguous] , alanine:alanine ligase (ADP-forming), and alanylalanine synthetase. This enzyme participates in d-alanine metabolism and peptidoglycan biosynthesis. At least one compound, Phosphinate is known to inhibit this enzyme.

tructural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1EHI, PDB link|1IOV, PDB link|1IOW, PDB link|2DLN, PDB link|2FB9, PDB link|2I80, PDB link|2I87, and PDB link|2I8C.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9023-63-6."

Gene Ontology (GO) codes