Pantoate-beta-alanine ligase

In enzymology, a pantoate-beta-alanine ligase (EC number|6.3.2.1) is an enzyme that catalyzes the chemical reaction

:ATP + (R)-pantoate + beta-alanine $ightleftharpoons$ AMP + diphosphate + (R)-pantothenate

The 3 substrates of this enzyme are ATP, (R)-pantoate, and beta-alanine, whereas its 3 products are AMP, diphosphate, and (R)-pantothenate.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is (R)-pantoate:beta-alanine ligase (AMP-forming). Other names in common use include pantothenate synthetase, pantoate activating enzyme, pantoic-activating enzyme, and D-pantoate:beta-alanine ligase (AMP-forming). This enzyme participates in beta-alanine metabolism and pantothenate and coa biosynthesis.

tructural studies

As of late 2007, 15 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1IHO, PDB link|1MOP, PDB link|1N2B, PDB link|1N2E, PDB link|1N2G, PDB link|1N2H, PDB link|1N2I, PDB link|1N2J, PDB link|1N2O, PDB link|1UFV, PDB link|1V8F, PDB link|2A7X, PDB link|2A84, PDB link|2A86, and PDB link|2A88.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9023-49-8."

Gene Ontology (GO) codes