UDP-N-acetylmuramate-L-alanine ligase

In enzymology, an UDP-N-acetylmuramate-L-alanine ligase (EC number|6.3.2.8) is an enzyme that catalyzes the chemical reaction

:ATP + UDP-N-acetylmuramate + L-alanine $ightleftharpoons$ ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine

The 3 substrates of this enzyme are ATP, UDP-N-acetylmuramate, and L-alanine, whereas its 3 products are ADP, phosphate, and UDP-N-acetylmuramoyl-L-alanine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is UDP-N-acetylmuramate:L-alanine ligase (ADP-forming). Other names in common use include MurC synthetase, UDP-N-acetylmuramoyl-L-alanine synthetase, uridine diphospho-N-acetylmuramoylalanine synthetase, UDP-N-acetylmuramoylalanine synthetase, L-alanine-adding enzyme, UDP-acetylmuramyl-L-alanine synthetase, UDPMurNAc-L-alanine synthetase, L-Ala ligase, uridine diphosphate N-acetylmuramate:L-alanine ligase, uridine 5'-diphosphate-N-acetylmuramyl-L-alanine synthetase, uridine-diphosphate-N-acetylmuramate:L-alanine ligase, UDP-MurNAc:L-alanine ligase, alanine-adding enzyme, and UDP-N-acetylmuramyl:L-alanine ligase. This enzyme participates in d-glutamine and d-glutamate metabolism and peptidoglycan biosynthesis.

tructural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1GQQ, PDB link|1GQY, PDB link|1J6U, PDB link|1P31, PDB link|1P3D, and PDB link|2F00.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9023-52-3."

Gene Ontology (GO) codes