Beta-lactamase inhibitor

Beta-lactamase inhibitor

A beta-lactamase inhibitor is a drug given in conjunction with a beta-lactam antibiotic. Although the inhibitor does not usually have significant antibiotic activity on its own, [cite web |url=http://www.fhsu.edu/nursing/otitis/bl_inhibit.html |title=Beta-Lactamase Inhibitors |date=October 2000 |accessdate=2007-08-17 |publisher=Department of Nursing of the Fort Hays State University College of Health and Life Sciences] it still plays an important role by disabling or slowing down the action of beta-lactamase which would normally be a mechanism of bacterial resistance to beta-lactam antibiotics as it lyses them.

Beta-lactamase inhibitors in clinical use include clavulanic acid and its potassium salt (usually combined with amoxicillin or ticarcillin), sulbactam and tazobactam.

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