Chloride potassium symporter 4

Solute carrier family 12 (potassium/chloride transporters), member 4
Identifiers
Symbols	SLC12A4; FLJ17069; FLJ40489; KCC1
External IDs	OMIM: 604119 MGI: 1309465 HomoloGene: 21056 GeneCards: SLC12A4 Gene
Gene Ontology Molecular function • transporter activity • symporter activity • potassium:chloride symporter activity Cellular component • membrane fraction • plasma membrane • integral to plasma membrane Biological process • transport • ion transport • potassium ion transport • sodium ion transport • chloride transport • cell volume homeostasis • transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6560	20498
Ensembl	ENSG00000124067	ENSMUSG00000017765
UniProt	Q9UP95	Q3TJG5
RefSeq (mRNA)	NM_001145961.1	NM_009195.2
RefSeq (protein)	NP_001139433.1	NP_033221.1
Location (UCSC)	Chr 16: 67.98 – 68 Mb	Chr 8: 108.47 – 108.49 Mb
PubMed search	[1]	[2]

Potassium-chloride transporter, member 4 is a chloride potassium symporter. It is encoded by the gene SLC12A4.^[1]

See also

• Solute carrier family

References

1. ^ "Entrez Gene: SLC12A4 solute carrier family 12 (potassium/chloride transporters), member 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6560. 

Further reading

• Larsen F, Solheim J, Kristensen T, et al. (1994). "A tight cluster of five unrelated human genes on chromosome 16q22.1.". Hum. Mol. Genet. 2 (10): 1589–95. doi:10.1093/hmg/2.10.1589. PMID 8268911. 
• Gillen CM, Brill S, Payne JA, Forbush B (1996). "Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family.". J. Biol. Chem. 271 (27): 16237–44. doi:10.1074/jbc.271.27.16237. PMID 8663127. 
• Pellegrino CM, Rybicki AC, Musto S, et al. (1998). "Molecular identification and expression of erythroid K:Cl cotransporter in human and mouse erythroleukemic cells.". Blood Cells Mol. Dis. 24 (1): 31–40. doi:10.1006/bcmd.1998.0168. PMID 9516379. 
• Su W, Shmukler BE, Chernova MN, et al. (1999). "Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation.". Am. J. Physiol. 277 (5 Pt 1): C899–912. PMID 10564083. 
• Casula S, Shmukler BE, Wilhelm S, et al. (2001). "A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity.". J. Biol. Chem. 276 (45): 41870–8. doi:10.1074/jbc.M107155200. PMID 11551954. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Bräuer M, Frei E, Claes L, et al. (2003). "Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts". Am. J. Physiol., Cell Physiol. 285 (1): C22–30. doi:10.1152/ajpcell.00289.2002. PMID 12637262. 
• Shen MR, Chou CY, Hsu KF, et al. (2003). "KCl cotransport is an important modulator of human cervical cancer growth and invasion". J. Biol. Chem. 278 (41): 39941–50. doi:10.1074/jbc.M308232200. PMID 12902337. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Zhou GP, Wong C, Su R, et al. (2004). "Human potassium chloride cotransporter 1 (SLC12A4) promoter is regulated by AP-2 and contains a functional downstream promoter element". Blood 103 (11): 4302–9. doi:10.1182/blood-2003-01-0107. PMID 14976052. 
• Khan AI, Drew C, Ball SE, et al. (2005). "Oxygen dependence of K(+)-Cl- cotransport in human red cell ghosts and sickle cells". Bioelectrochemistry (Amsterdam, Netherlands) 62 (2): 141–6. doi:10.1016/j.bioelechem.2003.07.005. PMID 15039017. 
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148. 
• Shen MR, Lin AC, Hsu YM, et al. (2004). "Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells". J. Biol. Chem. 279 (38): 40017–25. doi:10.1074/jbc.M406706200. PMID 15262997. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 

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