ATP1A4

ATP1A4

ATPase, Na+/K+ transporting, alpha 4 polypeptide, also known as ATP1A4, is a human gene.cite web | title = Entrez Gene: ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=480| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.cite web | title = Entrez Gene: ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=480| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lingrel JB, Orlowski J, Shull MM, Price EM |title=Molecular genetics of Na, K-ATPase. |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=38 |issue= |pages= 37–89 |year= 1990 |pmid= 2158121 |doi=
*cite journal | author=Buetow KH, Nishimura D, Nakamura Y, "et al." |title=A detailed multipoint gene map of chromosome 1q. |journal=Genomics |volume=8 |issue= 1 |pages= 13–21 |year= 1991 |pmid= 1981991 |doi=
*cite journal | author=Sverdlov ED, Broude NE, Sverdlov VE, "et al." |title=Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism. |journal=FEBS Lett. |volume=221 |issue= 1 |pages= 129–33 |year= 1987 |pmid= 2887455 |doi=
*cite journal | author=Shull MM, Lingrel JB |title=Multiple genes encode the human Na+,K+-ATPase catalytic subunit. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 12 |pages= 4039–43 |year= 1987 |pmid= 3035563 |doi=
*cite journal | author=Sverdlov ED, Monastyrskaya GS, Broude NE, "et al." |title=The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit. |journal=FEBS Lett. |volume=217 |issue= 2 |pages= 275–8 |year= 1987 |pmid= 3036582 |doi=
*cite journal | author=Shamraj OI, Lingrel JB |title=A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 26 |pages= 12952–6 |year= 1995 |pmid= 7809153 |doi=
*cite journal | author=Woo AL, James PF, Lingrel JB |title=Characterization of the fourth alpha isoform of the Na, K-ATPase. |journal=J. Membr. Biol. |volume=169 |issue= 1 |pages= 39–44 |year= 1999 |pmid= 10227850 |doi=
*cite journal | author=Woo AL, James PF, Lingrel JB |title=Sperm motility is dependent on a unique isoform of the Na, K-ATPase. |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20693–9 |year= 2000 |pmid= 10764792 |doi= 10.1074/jbc. M002323200
*cite journal | author=Woo AL, James PF, Lingrel JB |title=Roles of the Na, K-ATPase alpha4 isoform and the Na+/H+ exchanger in sperm motility. |journal=Mol. Reprod. Dev. |volume=62 |issue= 3 |pages= 348–56 |year= 2003 |pmid= 12112599 |doi= 10.1002/mrd.90002
*cite journal | author=Keryanov S, Gardner KL |title=Physical mapping and characterization of the human Na, K-ATPase isoform, ATP1A4. |journal=Gene |volume=292 |issue= 1-2 |pages= 151–66 |year= 2002 |pmid= 12119109 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Lingrel J, Moseley A, Dostanic I, "et al." |title=Functional roles of the alpha isoforms of the Na, K-ATPase. |journal=Ann. N. Y. Acad. Sci. |volume=986 |issue= |pages= 354–9 |year= 2003 |pmid= 12763850 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hlivko JT, Chakraborty S, Hlivko TJ, "et al." |title=The human Na, K-ATPase alpha 4 isoform is an ouabain-sensitive alpha isoform that is expressed in sperm. |journal=Mol. Reprod. Dev. |volume=73 |issue= 1 |pages= 101–15 |year= 2006 |pmid= 16175638 |doi= 10.1002/mrd.20383
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Rodova M, Nguyen AN, Blanco G |title=The transcription factor CREMtau and cAMP regulate promoter activity of the Na, K-ATPase alpha4 isoform. |journal=Mol. Reprod. Dev. |volume=73 |issue= 11 |pages= 1435–47 |year= 2006 |pmid= 16894555 |doi= 10.1002/mrd.20518

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