SLC19A1

Solute carrier family 19 (folate transporter), member 1, also known as SLC19A1, is a human gene.

PBB_Summary
section_title =
summary_text = Transport of folate compounds into mammalian cells can occur via receptor-mediated (see MIM 136430) or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate. [supplied by OMIM] cite web | title = Entrez Gene: SLC19A1 solute carrier family 19 (folate transporter), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6573| accessdate = ]

ee also

* Solute carrier family

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Matherly LH, Hou Z, Deng Y |title=Human reduced folate carrier: translation of basic biology to cancer etiology and therapy. |journal=Cancer Metastasis Rev. |volume=26 |issue= 1 |pages= 111–28 |year= 2007 |pmid= 17334909 |doi= 10.1007/s10555-007-9046-2
*cite journal | author=Wong SC, Proefke SA, Bhushan A, Matherly LH |title=Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells. |journal=J. Biol. Chem. |volume=270 |issue= 29 |pages= 17468–75 |year= 1995 |pmid= 7615551 |doi=
*cite journal | author=Moscow JA, Gong M, He R, "et al." |title=Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells. |journal=Cancer Res. |volume=55 |issue= 17 |pages= 3790–4 |year= 1995 |pmid= 7641195 |doi=
*cite journal | author=Yang-Feng TL, Ma YY, Liang R, "et al." |title=Assignment of the human folate transporter gene to chromosome 21q22.3 by somatic cell hybrid analysis and in situ hybridization. |journal=Biochem. Biophys. Res. Commun. |volume=210 |issue= 3 |pages= 874–9 |year= 1995 |pmid= 7763259 |doi=
*cite journal | author=Prasad PD, Ramamoorthy S, Leibach FH, Ganapathy V |title=Molecular cloning of the human placental folate transporter. |journal=Biochem. Biophys. Res. Commun. |volume=206 |issue= 2 |pages= 681–7 |year= 1995 |pmid= 7826387 |doi= 10.1006/bbrc.1995.1096
*cite journal | author=Williams FM, Flintoff WF |title=Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake. |journal=J. Biol. Chem. |volume=270 |issue= 7 |pages= 2987–92 |year= 1995 |pmid= 7852378 |doi=
*cite journal | author=Dixon KH, Lanpher BC, Chiu J, "et al." |title=A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells. |journal=J. Biol. Chem. |volume=269 |issue= 1 |pages= 17–20 |year= 1994 |pmid= 8276792 |doi=
*cite journal | author=Nguyen TT, Dyer DL, Dunning DD, "et al." |title=Human intestinal folate transport: cloning, expression, and distribution of complementary RNA. |journal=Gastroenterology |volume=112 |issue= 3 |pages= 783–91 |year= 1997 |pmid= 9041240 |doi=
*cite journal | author=Lapenta V, Sossi V, Gosset P, "et al." |title=Construction of a 2.5-Mb integrated physical and gene map of distal 21q22.3. |journal=Genomics |volume=49 |issue= 1 |pages= 1–13 |year= 1998 |pmid= 9570943 |doi= 10.1006/geno.1997.5185
*cite journal | author=Tolner B, Roy K, Sirotnak FM |title=Structural analysis of the human RFC-1 gene encoding a folate transporter reveals multiple promoters and alternatively spliced transcripts with 5' end heterogeneity. |journal=Gene |volume=211 |issue= 2 |pages= 331–41 |year= 1998 |pmid= 9602167 |doi=
*cite journal | author=Zhang L, Wong SC, Matherly LH |title=Structure and organization of the human reduced folate carrier gene. |journal=Biochim. Biophys. Acta |volume=1442 |issue= 2-3 |pages= 389–93 |year= 1998 |pmid= 9804996 |doi=
*cite journal | author=Ferguson PL, Flintoff WF |title=Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion. |journal=J. Biol. Chem. |volume=274 |issue= 23 |pages= 16269–78 |year= 1999 |pmid= 10347183 |doi=
*cite journal | author=Hattori M, Fujiyama A, Taylor TD, "et al." |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518
*cite journal | author=Whetstine JR, Gifford AJ, Witt T, "et al." |title=Single nucleotide polymorphisms in the human reduced folate carrier: characterization of a high-frequency G/A variant at position 80 and transport properties of the His(27) and Arg(27) carriers. |journal=Clin. Cancer Res. |volume=7 |issue= 11 |pages= 3416–22 |year= 2002 |pmid= 11705857 |doi=
*cite journal | author=Shaw GM, Lammer EJ, Zhu H, "et al." |title=Maternal periconceptional vitamin use, genetic variation of infant reduced folate carrier (A80G), and risk of spina bifida. |journal=Am. J. Med. Genet. |volume=108 |issue= 1 |pages= 1–6 |year= 2002 |pmid= 11857541 |doi=
*cite journal | author=Marchant JS, Subramanian VS, Parker I, Said HM |title=Intracellular trafficking and membrane targeting mechanisms of the human reduced folate carrier in Mammalian epithelial cells. |journal=J. Biol. Chem. |volume=277 |issue= 36 |pages= 33325–33 |year= 2002 |pmid= 12087110 |doi= 10.1074/jbc.M205955200
*cite journal | author=Rothem L, Ifergan I, Kaufman Y, "et al." |title=Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines. |journal=Biochem. J. |volume=367 |issue= Pt 3 |pages= 741–50 |year= 2002 |pmid= 12139489 |doi= 10.1042/BJ20020801
*cite journal | author=Whetstine JR, Flatley RM, Matherly LH |title=The human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: identification of seven non-coding exons and characterization of a novel promoter. |journal=Biochem. J. |volume=367 |issue= Pt 3 |pages= 629–40 |year= 2002 |pmid= 12144527 |doi= 10.1042/BJ20020512
*cite journal | author=Liu XY, Matherly LH |title=Analysis of membrane topology of the human reduced folate carrier protein by hemagglutinin epitope insertion and scanning glycosylation insertion mutagenesis. |journal=Biochim. Biophys. Acta |volume=1564 |issue= 2 |pages= 333–42 |year= 2002 |pmid= 12175915 |doi=
*cite journal | author=Liu XY, Witt TL, Matherly LH |title=Restoration of high-level transport activity by human reduced folate carrier/ThTr1 thiamine transporter chimaeras: role of the transmembrane domain 6/7 linker region in reduced folate carrier function. |journal=Biochem. J. |volume=369 |issue= Pt 1 |pages= 31–7 |year= 2003 |pmid= 12227830 |doi= 10.1042/BJ20020419

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