SLC22A1

Solute carrier family 22 (organic cation transporter), member 1
Identifiers
Symbols	SLC22A1; HOCT1; OCT1; oct1_cds
External IDs	OMIM: 602607 MGI: 108111 HomoloGene: 20665 GeneCards: SLC22A1 Gene
Gene Ontology Molecular function • protein binding • ion transmembrane transporter activity • organic cation transmembrane transporter activity • transmembrane transporter activity Cellular component • membrane fraction • plasma membrane • integral to plasma membrane • basolateral plasma membrane Biological process • organic cation transport • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6580	20517
Ensembl	ENSG00000175003	ENSMUSG00000023829
UniProt	O15245	n/a
RefSeq (mRNA)	NM_003057.2	NM_009202.5
RefSeq (protein)	NP_003048.1	NP_033228.2
Location (UCSC)	Chr 6: 160.54 – 160.58 Mb	Chr 17: 12.84 – 12.87 Mb
PubMed search	[1]	[2]

Solute carrier family 22 member 1 is a protein that in humans is encoded by the SLC22A1 gene.^[1][2]

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter.^[2]

See also

• Solute carrier family
• Organic cation transport proteins

References

1. ^ Koehler MR, Wissinger B, Gorboulev V, Koepsell H, Schmid M (Jun 1998). "The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26". Cytogenet Cell Genet 79 (3–4): 198–200. doi:10.1159/000134720. PMID 9605850. 
2. ^ ^{a b} "Entrez Gene: SLC22A1 solute carrier family 22 (organic cation transporter), member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6580. 

Further reading

• Berkhout B, Jeang KT (1992). "Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat". J. Virol. 66 (1): 139–49. PMC 238269. PMID 1727476. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=238269. 
• Jeang KT, Chun R, Lin NH et al. (1993). "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor". J. Virol. 67 (10): 6224–33. PMC 238044. PMID 7690421. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=238044. 
• Liu YZ, Lania L, Latchman DS (1997). "Functional interaction between the HIV-1 Tat transactivator and the inhibitory domain of the Oct-2 cellular transcription factor". AIDS 10 (12): 1323–9. doi:10.1097/00002030-199610000-00003. PMID 8902060. 
• Liu YZ, Latchman DS (1997). "The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat". Biochem. J. 322 ( Pt 1) (Pt 1): 155–8. PMC 1218171. PMID 9078256. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1218171. 
• Zhang L, Dresser MJ, Gray AT et al. (1997). "Cloning and functional expression of a human liver organic cation transporter". Mol. Pharmacol. 51 (6): 913–21. PMID 9187257. 
• Gorboulev V, Ulzheimer JC, Akhoundova A et al. (1997). "Cloning and characterization of two human polyspecific organic cation transporters". DNA Cell Biol. 16 (7): 871–81. doi:10.1089/dna.1997.16.871. PMID 9260930. 
• Verhaagh S, Schweifer N, Barlow DP, Zwart R (1999). "Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27". Genomics 55 (2): 209–18. doi:10.1006/geno.1998.5639. PMID 9933568. 
• Chasman D, Cepek K, Sharp PA, Pabo CO (1999). "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface". Genes Dev. 13 (20): 2650–7. doi:10.1101/gad.13.20.2650. PMC 317104. PMID 10541551. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=317104. 
• Tomilin A, Reményi A, Lins K et al. (2001). "Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration". Cell 103 (6): 853–64. doi:10.1016/S0092-8674(00)00189-6. PMID 11136971. 
• Hayer M, Bönisch H, Brüss M (2001). "Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1)". Ann. Hum. Genet. 63 (Pt 6): 473–82. doi:10.1017/S0003480099007770. PMID 11388889. 
• Pietig G, Mehrens T, Hirsch JR et al. (2001). "Properties and regulation of organic cation transport in freshly isolated human proximal tubules". J. Biol. Chem. 276 (36): 33741–6. doi:10.1074/jbc.M104617200. PMID 11447227. 
• Pan H, Qin WX, Huo KK et al. (2001). "Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1". Genomics 77 (1–2): 58–64. doi:10.1006/geno.2001.6614. PMID 11543633. 
• Xu XR, Huang J, Xu ZG et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=64988. 
• Schinkel AH, Jonker JW (2003). "Polymorphisms affecting function of the human organic cation transporter hOCT1 (SLC22A1): what are the consequences?". Pharmacogenetics 12 (8): 589–90. doi:10.1097/00008571-200211000-00001. PMID 12439217. 
• Kerb R, Brinkmann U, Chatskaia N et al. (2003). "Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences". Pharmacogenetics 12 (8): 591–5. doi:10.1097/00008571-200211000-00002. PMID 12439218. 
• Schaffer A, Kim EC, Wu X et al. (2003). "Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements". J. Biol. Chem. 278 (25): 23141–50. doi:10.1074/jbc.M212952200. PMID 12672812. 
• Shu Y, Leabman MK, Feng B et al. (2003). "Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 5902–7. doi:10.1073/pnas.0730858100. PMC 156299. PMID 12719534. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=156299. 
• Sakata T, Anzai N, Shin HJ et al. (2004). "Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions". Biochem. Biophys. Res. Commun. 313 (3): 789–93. doi:10.1016/j.bbrc.2003.11.175. PMID 14697261. 
• Bottalico B, Larsson I, Brodszki J et al. (2004). "Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies". Placenta 25 (6): 518–29. doi:10.1016/j.placenta.2003.10.017. PMID 15135235. 

SLC11–20
(11) proton coupled metal ion transporter (SLC11A1, SLC11A2) 11A3 (12) electroneutral cation-Cl cotransporter (SLC12A1, SLC12A1, SLC12A2, SLC12A3, SLC12A4, SLC12A5, SLC12A6, SLC12A7, SLC12A8, SLC12A9) (13) human Na+-sulfate/carboxylate cotransporter (SLC13A1, SLC13A2, SLC13A3, SLC13A4, SLC13A5) (14) urea transporter (SLC14A1, SLC14A2) (15) proton oligopeptide cotransporter (SLC15A1, SLC15A2, SLC15A3, SLC15A4) (16) monocarboxylate transporter (SLC16A1, SLC16A2, SLC16A3, SLC16A4, SLC16A5, SLC16A6, SLC16A7, SLC16A8, SLC16A9, SLC16A10, SLC16A11, SLC16A12, SLC16A13, SLC16A14) (17) vesicular glutamate transporter (SLC17A1, SLC17A2, SLC17A3, SLC17A4, SLC17A5, SLC17A6, SLC17A7, SLC17A8, SLC17A9) (18) vesicular amine transporter (SLC18A1, SLC18A2, SLC18A3) (19) folate/thiamine transporter (SLC19A1, SLC19A2, SLC19A3) (20) type III Na+-phosphate cotransporter (SLC20A1, SLC20A2)

SLC21–30
(21) organic anion transporting (SLCO1A2, SLCO1B1, SLCO1B3, SLCO1B4, SLCO1C1) (SLCO2A1, SLCO2B1) (SLCO3A1) (SLCO4A1, SLCO4C1) (SLCO5A1) (SLCO6A1) (22) organic cation/anion/zwitterion transporter (SLC22A1, SLC22A2, SLC22A3, SLC22A4, SLC22A5, SLC22A6, SLC22A7, SLC22A8, SLC22A9, SLC22A10, SLC22A11, SLC22A12, SLC22A13, SLC22A14, SLC22A15, SLC22A16, SLC22A17, SLC22A18, SLC22A19, SLC22A20) (23) Na+-dependent ascorbic acid transporter (SLC23A1, SLC23A2, SLC23A3, SLC23A4) (24) Na+/(Ca2+-K+) exchanger (SLC24A1, SLC24A2, SLC24A3, SLC24A4, SLC24A5, SLC24A6) (25) mitochondrial carrier (SLC25A1, SLC25A2, SLC25A3, SLC25A4, SLC25A5, SLC25A6, SLC25A7, SLC25A8, SLC25A9, SLC25A10, SLC25A11, SLC25A12, SLC25A13, SLC25A14, SLC25A15, SLC25A16, SLC25A17, SLC25A18, SLC25A19, SLC25A20, SLC25A21, SLC25A22, SLC25A23, SLC25A24, SLC25A25, SLC25A26, SLC25A27, SLC25A28, SLC25A29, SLC25A30, SLC25A31, SLC25A32, SLC25A33, SLC25A34, SLC25A35, SLC25A36, SLC25A37, SLC25A38, SLC25A39, SLC25A40, SLC25A41, SLC25A42, SLC25A43, SLC25A44, SLC25A45, SLC25A46) (26) multifunctional anion exchanger (SLC26A1, SLC26A2, SLC26A3, SLC26A4, SLC26A5, SLC26A6, SLC26A7, SLC26A8, SLC26A9, SLC26A10, SLC26A11) (27) fatty acid transport proteins (SLC27A1, SLC27A2, SLC27A3, SLC27A4, SLC27A5, SLC27A6) (28) Na+-coupled nucleoside transport (SLC28A1, SLC28A2, SLC28A3 (29) facilitative nucleoside transporter (SLC29A1, SLC29A2, SLC29A3, SLC29A4) (30) zinc efflux (SLC30A1, SLC30A2, SLC30A3, SLC30A4, SLC30A5, SLC30A6, SLC30A7, SLC30A8, SLC30A9, SLC30A10)

SLC31–40
(31) copper transporter (SLC31A1) (32) vesicular inhibitory amino-acid transporter (SLC32A1) (33) Acetyl-CoA transporter (SLC33A1) (34) type II Na+-phosphate cotransporter (SLC34A1, SLC34A2, SLC34A3) (35) nucleoside-sugar transporter (SLC35A1, SLC35A2, SLC35A3, SLC35A4, SLC35A5) (SLC35B1, SLC35B2, SLC35B3, SLC35B4) (SLC35C1, SLC35C2) (SLC35D1, SLC35D2, SLC35D3) (SLC35E1, SLC35E2, SLC35E3, SLC35E4) (36) proton-coupled amino-acid transporter (SLC36A1, SLC36A2, SLC36A3, SLC36A4)36A2 · (37) sugar-phosphate/phosphate exchanger (SLC37A1, SLC37A2, SLC37A3, SLC37A4) (38) System A & N, sodium-coupled neutral amino-acid transporter (SLC38A1, SLC38A2, SLC38A3, SLC38A4, SLC38A5, SLC38A6, SLC38A10) (39) metal ion transporter (SLC39A1, SLC39A2, SLC39A3, SLC39A4, SLC39A5, SLC39A6, SLC39A7, SLC39A8, SLC39A9, SLC39A10, SLC39A11, SLC39A12, SLC39A13, SLC39A14) (40) basolateral iron transporter (SLC40A1)

SLC41–48
(41) MgtE-like magnesium transporter (SLC41A1, SLC41A2, SLC41A3) (42) Ammonia transporter (RhAG, RhBG, RhCG) (43) Na+-independent, system-L like amino-acid transporter (SLC43A1, SLC43A2, SLC43A3) (44) Choline-like transporter (SLC44A1, SLC44A2, SLC44A3, SLC44A4, SLC44A5) (45) Putative sugar transporter (SLC45A1, SLC45A2, SLC54A3, SLC45A4) (46) Folate transporter (SLC46A1, SLC46A2) (47) multidrug and toxin extrusion (SLC47A1, SLC47A2) (48) Heme transporter

SLCO1–4
O1A2 · O1B1 · O1B3 · O2B1 · O431 · O4A1

Ion pumps
Symporter, Cotransporter Na+/K+/2Cl- - Na/Pi3 - Na+/Cl- - Na/glucose - Na+/I- - Cl-/K+ (4, 5) Antiporter (exchanger) Na+/H+ - Na+/Ca2+ (Na+/(Ca2+-K+)) - Cl-/HCO3- (Band 3) - Cl-formate exchanger - Cl-oxalate exchanger

see also solute carrier disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), othr