Ferroportin

Ferroportin is a transmembrane protein that transports iron from the inside of a cell to the outside of it. It is found on the surface of cells that store or transport iron, including:

*Enterocytes in the duodenum
*Hepatocytes
*Macrophages of the reticuloendothelial system.

Recent research suggests that ferroportin is inhibited by hepcidin, which therefore is the "master regulator" of human iron metabolism. Hepcidin binds to ferroportin, and results in the internalisation of ferroportin within the cell. This results in retention of iron within the cell, and a reduction in iron levels within the plasma. This is part of the mechanism that causes anaemia of chronic disease; hepcidin is released from the liver in response to inflammatory cytokines, namely interleukin-6, which results in an increased hepcidin concentration and a consequent decrease in plasma iron levels.

Clinical significance

Ferroportin can be associated with African iron overload.

References

Further reading

*cite journal | author=Schimanski LM "et al." |title="In vitro" functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations. |journal=Blood |volume=105 |issue= 10 |pages= 4096–4102 |year= 2005 |pmid= |doi= PBB_Further_reading
citations =
*cite journal | author=Pietrangelo A |title=The ferroportin disease. |journal=Blood Cells Mol. Dis. |volume=32 |issue= 1 |pages= 131–8 |year= 2004 |pmid= 14757427 |doi=
*cite journal | author=Robson KJ, Merryweather-Clarke AT, Cadet E, "et al." |title=Recent advances in understanding haemochromatosis: a transition state. |journal=J. Med. Genet. |volume=41 |issue= 10 |pages= 721–30 |year= 2005 |pmid= 15466004 |doi= 10.1136/jmg.2004.020644
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Donovan A, Brownlie A, Zhou Y, "et al." |title=Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. |journal=Nature |volume=403 |issue= 6771 |pages= 776–81 |year= 2000 |pmid= 10693807 |doi= 10.1038/35001596
*cite journal | author=Abboud S, Haile DJ |title=A novel mammalian iron-regulated protein involved in intracellular iron metabolism. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 19906–12 |year= 2000 |pmid= 10747949 |doi= 10.1074/jbc.M000713200
*cite journal | author=Haile DJ |title=Assignment of Slc11a3 to mouse chromosome 1 band 1B and SLC11A3 to human chromosome 2q32 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3-4 |pages= 328–9 |year= 2000 |pmid= 10828623 |doi=
*cite journal | author=McKie AT, Marciani P, Rolfs A, "et al." |title=A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. |journal=Mol. Cell |volume=5 |issue= 2 |pages= 299–309 |year= 2000 |pmid= 10882071 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058
*cite journal | author=Njajou OT, Vaessen N, Joosse M, "et al." |title=A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis. |journal=Nat. Genet. |volume=28 |issue= 3 |pages= 213–4 |year= 2001 |pmid= 11431687 |doi= 10.1038/90038
*cite journal | author=Montosi G, Donovan A, Totaro A, "et al." |title=Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene. |journal=J. Clin. Invest. |volume=108 |issue= 4 |pages= 619–23 |year= 2001 |pmid= 11518736 |doi=
*cite journal | author=Press RD |title=Hemochromatosis caused by mutations in the iron-regulatory proteins ferroportin and H ferritin. |journal=Mol. Diagn. |volume=6 |issue= 4 |pages= 347 |year= 2002 |pmid= 11774199 |doi=
*cite journal | author=Lee PL, Gelbart T, West C, "et al." |title=A study of genes that may modulate the expression of hereditary hemochromatosis: transferrin receptor-1, ferroportin, ceruloplasmin, ferritin light and heavy chains, iron regulatory proteins (IRP)-1 and -2, and hepcidin. |journal=Blood Cells Mol. Dis. |volume=27 |issue= 5 |pages= 783–802 |year= 2003 |pmid= 11783942 |doi= 10.1006/bcmd.2001.0445
*cite journal | author=Rolfs A, Bonkovsky HL, Kohlroser JG, "et al." |title=Intestinal expression of genes involved in iron absorption in humans. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=282 |issue= 4 |pages= G598–607 |year= 2002 |pmid= 11897618 |doi= 10.1152/ajpgi.00371.2001
*cite journal | author=Thomas C, Oates PS |title=IEC-6 cells are an appropriate model of intestinal iron absorption in rats. |journal=J. Nutr. |volume=132 |issue= 4 |pages= 680–7 |year= 2002 |pmid= 11925460 |doi=
*cite journal | author=Wallace DF, Pedersen P, Dixon JL, "et al." |title=Novel mutation in ferroportin1 is associated with autosomal dominant hemochromatosis. |journal=Blood |volume=100 |issue= 2 |pages= 692–4 |year= 2002 |pmid= 12091366 |doi=
*cite journal | author=Devalia V, Carter K, Walker AP, "et al." |title=Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3). |journal=Blood |volume=100 |issue= 2 |pages= 695–7 |year= 2002 |pmid= 12091367 |doi= 10.1182/blood-2001-11-0132
*cite journal | author=Roetto A, Merryweather-Clarke AT, Daraio F, "et al." |title=A valine deletion of ferroportin 1: a common mutation in hemochromastosis type 4. |journal=Blood |volume=100 |issue= 2 |pages= 733–4 |year= 2002 |pmid= 12123233 |doi=

External links

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