- SLC24A5
protein
Name=solute carrier family 24, member 5
caption=
width=
HGNCid=20611
Symbol=SLC24A5
AltSymbols=
EntrezGene=283652
OMIM=609802
RefSeq=NM_205850
UniProt=Q71RS6
PDB=
ECnumber=
Chromosome=15
Arm=q
Band=15.2
LocusSupplementaryData=SLC24A5 (solute carrier family 24, member 5) is a
gene that is thought to explain between 25 and 38% ofskin pigmentation variation between Black African and White Europeanhuman s.Research done by a large team at
Penn State University and a number of other institutions discovered that the gene has two primaryallele s that differ in only onenucleotide , changing the 111thamino acid fromalanine tothreonine . [cite journal |author=Lamason RL, Mohideen MA, Mest JR, "et al" |title=SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans |journal=Science |volume=310 |issue=5755 |pages=1782–6 |year=2005 |pmid=16357253 |doi=10.1126/science.1116238] [ [http://news.bbc.co.uk/2/hi/health/4531966.stm BBC article] ] [ [http://live.psu.edu/story/15166 Penn State University article] ]The threonine allele was present in 98.7 to 100% among several European samples, while the alanine form was found in 93 to 100% of samples of Africans, East Asians and Indigenous Americans. The variation is a SNP polymorphism rs1426654, which had been previously shown to be second among 3011 tabulated SNPs ranked as
ancestry-informative marker s. They also showed that SLC24A5 explains between 25 and 38% of the European-African difference in skinmelanin index.The discovery of this gene may have interesting social consequences because of its bearing on the genetics of ethnic differences. It has obvious application to forensic science as well.
The SLC24A5 gene is located on the long (q) arm of chromosome 15 on position 21.1, from
base pair 46,200,461 to base pair 46,221,881.It is currently estimated that the threonine allele became predominant amongst Europeans 5,300 to 12,000 years ago. [cite journal |author=Gibbons A |title=American Association of Physical Anthropologists meeting. European skin turned pale only recently, gene suggests |journal=Science |volume=316 |issue=5823 |pages=364 |year=2007 |pmid=17446367 |doi=10.1126/science.316.5823.364a |url=http://img46.imageshack.us/img46/4784/eurospaleonlyrecentlypu0.jpg]
ee also
*Race
References
External links
*MeshName|SLC24A5+protein,+human
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