- SLC23A1
Solute carrier family 23 (nucleobase transporters), member 1, also known as SLC23A1, is a human
gene .cite web | title = Entrez Gene: SLC23A1 solute carrier family 23 (nucleobase transporters), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9963| accessdate = ]PBB_Summary
section_title =
summary_text = The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2.cite web | title = Entrez Gene: SLC23A1 solute carrier family 23 (nucleobase transporters), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9963| accessdate = ]ee also
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Solute carrier family References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Liang WJ, Johnson D, Jarvis SM |title=Vitamin C transport systems of mammalian cells. |journal=Mol. Membr. Biol. |volume=18 |issue= 1 |pages= 87–95 |year= 2001 |pmid= 11396616 |doi=
*cite journal | author=Faaland CA, Race JE, Ricken G, "et al." |title=Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters. |journal=Biochim. Biophys. Acta |volume=1442 |issue= 2-3 |pages= 353–60 |year= 1998 |pmid= 9804989 |doi=
*cite journal | author=Tsukaguchi H, Tokui T, Mackenzie B, "et al." |title=A family of mammalian Na+-dependent L-ascorbic acid transporters. |journal=Nature |volume=399 |issue= 6731 |pages= 70–5 |year= 1999 |pmid= 10331392 |doi= 10.1038/19986
*cite journal | author=Hogue DL, Ling V |title=A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals. |journal=Genomics |volume=59 |issue= 1 |pages= 18–23 |year= 1999 |pmid= 10395795 |doi= 10.1006/geno.1999.5847
*cite journal | author=Rajan DP, Huang W, Dutta B, "et al." |title=Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function. |journal=Biochem. Biophys. Res. Commun. |volume=262 |issue= 3 |pages= 762–8 |year= 1999 |pmid= 10471399 |doi= 10.1006/bbrc.1999.1272
*cite journal | author=Wang H, Dutta B, Huang W, "et al." |title=Human Na(+)-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non-functional splice variant. |journal=Biochim. Biophys. Acta |volume=1461 |issue= 1 |pages= 1–9 |year= 1999 |pmid= 10556483 |doi=
*cite journal | author=Daruwala R, Song J, Koh WS, "et al." |title=Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2. |journal=FEBS Lett. |volume=460 |issue= 3 |pages= 480–4 |year= 1999 |pmid= 10556521 |doi=
*cite journal | author=Wang Y, Mackenzie B, Tsukaguchi H, "et al." |title=Human vitamin C (L-ascorbic acid) transporter SVCT1. |journal=Biochem. Biophys. Res. Commun. |volume=267 |issue= 2 |pages= 488–94 |year= 2000 |pmid= 10631088 |doi= 10.1006/bbrc.1999.1929
*cite journal | author=Erichsen HC, Eck P, Levine M, Chanock S |title=Characterization of the genomic structure of the human vitamin C transporter SVCT1 (SLC23A2). |journal=J. Nutr. |volume=131 |issue= 10 |pages= 2623–7 |year= 2001 |pmid= 11584081 |doi=
*cite journal | author=Hediger MA |title=New view at C. |journal=Nat. Med. |volume=8 |issue= 5 |pages= 445–6 |year= 2002 |pmid= 11984580 |doi= 10.1038/nm0502-445
*cite journal | author=Maulén NP, Henríquez EA, Kempe S, "et al." |title=Up-regulation and polarized expression of the sodium-ascorbic acid transporter SVCT1 in post-confluent differentiated CaCo-2 cells. |journal=J. Biol. Chem. |volume=278 |issue= 11 |pages= 9035–41 |year= 2003 |pmid= 12381735 |doi= 10.1074/jbc.M205119200
*cite journal | author=Liang WJ, Johnson D, Ma LS, "et al." |title=Regulation of the human vitamin C transporters expressed in COS-1 cells by protein kinase C [corrected] . |journal=Am. J. Physiol., Cell Physiol. |volume=283 |issue= 6 |pages= C1696–704 |year= 2002 |pmid= 12388072 |doi= 10.1152/ajpcell.00461.2001
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Subramanian VS, Marchant JS, Boulware MJ, Said HM |title=A C-terminal region dictates the apical plasma membrane targeting of the human sodium-dependent vitamin C transporter-1 in polarized epithelia. |journal=J. Biol. Chem. |volume=279 |issue= 26 |pages= 27719–28 |year= 2004 |pmid= 15084584 |doi= 10.1074/jbc.M400876200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Boyer JC, Campbell CE, Sigurdson WJ, Kuo SM |title=Polarized localization of vitamin C transporters, SVCT1 and SVCT2, in epithelial cells. |journal=Biochem. Biophys. Res. Commun. |volume=334 |issue= 1 |pages= 150–6 |year= 2005 |pmid= 15993839 |doi= 10.1016/j.bbrc.2005.06.069
*cite journal | author=Erichsen HC, Engel SA, Eck PK, "et al." |title=Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery. |journal=Am. J. Epidemiol. |volume=163 |issue= 3 |pages= 245–54 |year= 2006 |pmid= 16357110 |doi= 10.1093/aje/kwj035
*cite journal | author=Kang JS, Kim HN, Jung da J, "et al." |title=Regulation of UVB-induced IL-8 and MCP-1 production in skin keratinocytes by increasing vitamin C uptake via the redistribution of SVCT-1 from the cytosol to the membrane. |journal=J. Invest. Dermatol. |volume=127 |issue= 3 |pages= 698–706 |year= 2007 |pmid= 17008880 |doi= 10.1038/sj.jid.5700572PBB_Controls
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