SCO2

SCO cytochrome oxidase deficient homolog 2 (yeast), also known as SCO2, is a human gene.cite web | title = Entrez Gene: SCO2 SCO cytochrome oxidase deficient homolog 2 (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9997| accessdate = ]

PBB_Summary
section_title =
summary_text = Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog of the yeast SCO2 gene.cite web | title = Entrez Gene: SCO2 SCO cytochrome oxidase deficient homolog 2 (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9997| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Paret C, Ostermann K, Krause-Buchholz U, "et al." |title=Human members of the SCO1 gene family: complementation analysis in yeast and intracellular localization. |journal=FEBS Lett. |volume=447 |issue= 1 |pages= 65–70 |year= 1999 |pmid= 10218584 |doi=
*cite journal | author=Papadopoulou LC, Sue CM, Davidson MM, "et al." |title=Fatal infantile cardioencephalomyopathy with COX deficiency and mutations in SCO2, a COX assembly gene. |journal=Nat. Genet. |volume=23 |issue= 3 |pages= 333–7 |year= 1999 |pmid= 10545952 |doi= 10.1038/15513
*cite journal | author=Jaksch M, Ogilvie I, Yao J, "et al." |title=Mutations in SCO2 are associated with a distinct form of hypertrophic cardiomyopathy and cytochrome c oxidase deficiency. |journal=Hum. Mol. Genet. |volume=9 |issue= 5 |pages= 795–801 |year= 2000 |pmid= 10749987 |doi=
*cite journal | author=Jaksch M, Horvath R, Horn N, "et al." |title=Homozygosity (E140K) in SCO2 causes delayed infantile onset of cardiomyopathy and neuropathy. |journal=Neurology |volume=57 |issue= 8 |pages= 1440–6 |year= 2001 |pmid= 11673586 |doi=
*cite journal | author=Jaksch M, Paret C, Stucka R, "et al." |title=Cytochrome c oxidase deficiency due to mutations in SCO2, encoding a mitochondrial copper-binding protein, is rescued by copper in human myoblasts. |journal=Hum. Mol. Genet. |volume=10 |issue= 26 |pages= 3025–35 |year= 2002 |pmid= 11751685 |doi=
*cite journal | author=Salviati L, Hernandez-Rosa E, Walker WF, "et al." |title=Copper supplementation restores cytochrome c oxidase activity in cultured cells from patients with SCO2 mutations. |journal=Biochem. J. |volume=363 |issue= Pt 2 |pages= 321–7 |year= 2002 |pmid= 11931660 |doi=
*cite journal | author=Salviati L, Sacconi S, Rasalan MM, "et al." |title=Cytochrome c oxidase deficiency due to a novel SCO2 mutation mimics Werdnig-Hoffmann disease. |journal=Arch. Neurol. |volume=59 |issue= 5 |pages= 862–5 |year= 2002 |pmid= 12020273 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Collins JE, Goward ME, Cole CG, "et al." |title=Reevaluating human gene annotation: a second-generation analysis of chromosome 22. |journal=Genome Res. |volume=13 |issue= 1 |pages= 27–36 |year= 2003 |pmid= 12529303 |doi= 10.1101/gr.695703
*cite journal | author=Sacconi S, Salviati L, Sue CM, "et al." |title=Mutation screening in patients with isolated cytochrome c oxidase deficiency. |journal=Pediatr. Res. |volume=53 |issue= 2 |pages= 224–30 |year= 2003 |pmid= 12538779 |doi=
*cite journal | author=Tarnopolsky MA, Bourgeois JM, Fu MH, "et al." |title=Novel SCO2 mutation (G1521A) presenting as a spinal muscular atrophy type I phenotype. |journal=Am. J. Med. Genet. A |volume=125 |issue= 3 |pages= 310–4 |year= 2004 |pmid= 14994243 |doi= 10.1002/ajmg.a.20466
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Leary SC, Kaufman BA, Pellecchia G, "et al." |title=Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase. |journal=Hum. Mol. Genet. |volume=13 |issue= 17 |pages= 1839–48 |year= 2005 |pmid= 15229189 |doi= 10.1093/hmg/ddh197
*cite journal | author=Collins JE, Wright CL, Edwards CA, "et al." |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Stiburek L, Vesela K, Hansikova H, "et al." |title=Tissue-specific cytochrome c oxidase assembly defects due to mutations in SCO2 and SURF1. |journal=Biochem. J. |volume=392 |issue= Pt 3 |pages= 625–32 |year= 2006 |pmid= 16083427 |doi= 10.1042/BJ20050807
*cite journal | author=Horng YC, Leary SC, Cobine PA, "et al." |title=Human Sco1 and Sco2 function as copper-binding proteins. |journal=J. Biol. Chem. |volume=280 |issue= 40 |pages= 34113–22 |year= 2005 |pmid= 16091356 |doi= 10.1074/jbc.M506801200
*cite journal | author=Matoba S, Kang JG, Patino WD, "et al." |title=p53 regulates mitochondrial respiration. |journal=Science |volume=312 |issue= 5780 |pages= 1650–3 |year= 2006 |pmid= 16728594 |doi= 10.1126/science.1126863
*cite journal | author=Leary SC, Cobine PA, Kaufman BA, "et al." |title=The human cytochrome c oxidase assembly factors SCO1 and SCO2 have regulatory roles in the maintenance of cellular copper homeostasis. |journal=Cell Metab. |volume=5 |issue= 1 |pages= 9–20 |year= 2007 |pmid= 17189203 |doi= 10.1016/j.cmet.2006.12.001
*cite journal | author=Banci L, Bertini I, Ciofi-Baffoni S, "et al." |title=A structural characterization of human SCO2. |journal=Structure |volume=15 |issue= 9 |pages= 1132–40 |year= 2007 |pmid= 17850752 |doi= 10.1016/j.str.2007.07.011

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