SLC22A3

SLC22A3

Solute carrier family 22 (extraneuronal monoamine transporter), member 3, also known as SLC22A3, is a human gene.cite web | title = Entrez Gene: SLC22A3 solute carrier family 22 (extraneuronal monoamine transporter), member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6581| accessdate = ]

PBB_Summary
section_title =
summary_text = Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein.cite web | title = Entrez Gene: SLC22A3 solute carrier family 22 (extraneuronal monoamine transporter), member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6581| accessdate = ]

ee also

* Solute carrier family

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kekuda R, Prasad PD, Wu X, "et al." |title=Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. |journal=J. Biol. Chem. |volume=273 |issue= 26 |pages= 15971–9 |year= 1998 |pmid= 9632645 |doi=
*cite journal | author=Wu X, Kekuda R, Huang W, "et al." |title=Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. |journal=J. Biol. Chem. |volume=273 |issue= 49 |pages= 32776–86 |year= 1999 |pmid= 9830022 |doi=
*cite journal | author=Verhaagh S, Schweifer N, Barlow DP, Zwart R |title=Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. |journal=Genomics |volume=55 |issue= 2 |pages= 209–18 |year= 1999 |pmid= 9933568 |doi= 10.1006/geno.1998.5639
*cite journal | author=Gründemann D, Schechinger B, Rappold GA, Schömig E |title=Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. |journal=Nat. Neurosci. |volume=1 |issue= 5 |pages= 349–51 |year= 1999 |pmid= 10196521 |doi= 10.1038/1557
*cite journal | author=Gründemann D, Schömig E |title=Gene structures of the human non-neuronal monoamine transporters EMT and OCT2. |journal=Hum. Genet. |volume=106 |issue= 6 |pages= 627–35 |year= 2000 |pmid= 10942111 |doi=
*cite journal | author=Wu X, Huang W, Ganapathy ME, "et al." |title=Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. |journal=Am. J. Physiol. Renal Physiol. |volume=279 |issue= 3 |pages= F449–58 |year= 2000 |pmid= 10966924 |doi=
*cite journal | author=Wieland A, Hayer-Zillgen M, Bönisch H, Brüss M |title=Analysis of the gene structure of the human (SLC22A3) and murine (Slc22a3) extraneuronal monoamine transporter. |journal=Journal of neural transmission (Vienna, Austria : 1996) |volume=107 |issue= 10 |pages= 1149–57 |year= 2001 |pmid= 11129104 |doi=
*cite journal | author=Wessler I, Roth E, Deutsch C, "et al." |title=Release of non-neuronal acetylcholine from the isolated human placenta is mediated by organic cation transporters. |journal=Br. J. Pharmacol. |volume=134 |issue= 5 |pages= 951–6 |year= 2001 |pmid= 11682442 |doi= 10.1038/sj.bjp.0704335
*cite journal | author=Martel F, Keating E, Calhau C, "et al." |title=Regulation of human extraneuronal monoamine transporter (hEMT) expressed in HEK293 cells by intracellular second messenger systems. |journal=Naunyn Schmiedebergs Arch. Pharmacol. |volume=364 |issue= 6 |pages= 487–95 |year= 2002 |pmid= 11770002 |doi=
*cite journal | author=Hayer-Zillgen M, Brüss M, Bönisch H |title=Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. |journal=Br. J. Pharmacol. |volume=136 |issue= 6 |pages= 829–36 |year= 2003 |pmid= 12110607 |doi= 10.1038/sj.bjp.0704785
*cite journal | author=Gründemann D, Hahne C, Berkels R, Schömig E |title=Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2). |journal=J. Pharmacol. Exp. Ther. |volume=304 |issue= 2 |pages= 810–7 |year= 2003 |pmid= 12538837 |doi= 10.1124/jpet.102.044404
*cite journal | author=Lazar A, Gründemann D, Berkels R, "et al." |title=Genetic variability of the extraneuronal monoamine transporter EMT (SLC22A3). |journal=J. Hum. Genet. |volume=48 |issue= 5 |pages= 226–30 |year= 2003 |pmid= 12768439 |doi= 10.1007/s10038-003-0015-5
*cite journal | author=Haag C, Berkels R, Gründemann D, "et al." |title=The localisation of the extraneuronal monoamine transporter (EMT) in rat brain. |journal=J. Neurochem. |volume=88 |issue= 2 |pages= 291–7 |year= 2004 |pmid= 14690517 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Bottalico B, Larsson I, Brodszki J, "et al." |title=Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies. |journal=Placenta |volume=25 |issue= 6 |pages= 518–29 |year= 2004 |pmid= 15135235 |doi= 10.1016/j.placenta.2003.10.017
*cite journal | author=Jiang W, Prokopenko O, Wong L, "et al." |title=IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity. |journal=Mol. Cell. Biol. |volume=25 |issue= 15 |pages= 6496–508 |year= 2005 |pmid= 16024787 |doi= 10.1128/MCB.25.15.6496-6508.2005
*cite journal | author=Bourdet DL, Pritchard JB, Thakker DR |title=Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3). |journal=J. Pharmacol. Exp. Ther. |volume=315 |issue= 3 |pages= 1288–97 |year= 2006 |pmid= 16141367 |doi= 10.1124/jpet.105.091223
*cite journal | author=Aoyama N, Takahashi N, Kitaichi K, "et al." |title=Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder. |journal=Alcohol. Clin. Exp. Res. |volume=30 |issue= 10 |pages= 1644–9 |year= 2006 |pmid= 17010131 |doi= 10.1111/j.1530-0277.2006.00215.x
*cite journal | author=Bottalico B, Noskova V, Pilka R, "et al." |title=The organic cation transporters (OCT1, OCT2, EMT) and the plasma membrane monoamine transporter (PMAT) show differential distribution and cyclic expression pattern in human endometrium and early pregnancy decidua. |journal=Mol. Reprod. Dev. |volume=74 |issue= 10 |pages= 1303–11 |year= 2007 |pmid= 17393420 |doi= 10.1002/mrd.20697

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • SLC22A1 — Solute carrier family 22 (organic cation transporter), member 1 Identifiers Symbols SLC22A1; HOCT1; OCT1; oct1 cds External IDs …   Wikipedia

  • SLC22A2 — Solute carrier family 22 (organic cation transporter), member 2, also known as SLC22A2, is a human gene.cite web | title = Entrez Gene: SLC22A2 solute carrier family 22 (organic cation transporter), member 2| url =… …   Wikipedia

  • Membrane transport protein — A membrane transport protein (or simply transporter) is a membrane protein[1] involved in the movement of ions, small molecules, or macromolecules, such as another protein across a biological membrane. Transport proteins are integral membrane… …   Wikipedia

  • Dopamine transporter — Solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Identifiers Symbols …   Wikipedia

  • Norepinephrine transporter — Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Identifiers Symbols SLC6A2; NAT1; NET; NET1; SLC6A5 External IDs …   Wikipedia

  • Glucose transporter — Glucose Glucose transporters are a wide group of membrane proteins that facilitate the transport of glucose over a plasma membrane. Because glucose is a vital source of energy for all life these transporters are present in all phyla. The GLUT or… …   Wikipedia

  • Band 3 — Solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) Atomic microscope image of Band 3 …   Wikipedia

  • Solute carrier family — The SoLute Carrier (SLC) group of membrane transport proteins include over 300 members organized into 47 families.cite journal |author=Hediger MA, Romero MF, Peng JB, Rolfs A, Takanaga H, Bruford EA|title=The ABCs of solute carriers:… …   Wikipedia

  • Sodium-glucose transport proteins — solute carrier family 5 (sodium/glucose cotransporter), member 1 Identifiers Symbol SLC5A1 Alt. symbols SGLT1 Entrez …   Wikipedia

  • Sodium-chloride symporter — Solute carrier family 12 (sodium/chloride transporters), member 3 Identifiers Symbols SLC12A3; FLJ96318; NCCT; TSC External IDs …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”