SLC22A2

Solute carrier family 22 (organic cation transporter), member 2, also known as SLC22A2, is a human gene.cite web | title = Entrez Gene: SLC22A2 solute carrier family 22 (organic cation transporter), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6582| accessdate = ]

PBB_Summary
section_title =
summary_text = Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.cite web | title = Entrez Gene: SLC22A2 solute carrier family 22 (organic cation transporter), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6582| accessdate = ]

ee also

* Solute carrier family

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Berkhout B, Jeang KT |title=Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat. |journal=J. Virol. |volume=66 |issue= 1 |pages= 139–49 |year= 1992 |pmid= 1727476 |doi=
*cite journal | author=Jeang KT, Chun R, Lin NH, "et al." |title=In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor. |journal=J. Virol. |volume=67 |issue= 10 |pages= 6224–33 |year= 1993 |pmid= 7690421 |doi=
*cite journal | author=Liu YZ, Lania L, Latchman DS |title=Functional interaction between the HIV-1 Tat transactivator and the inhibitory domain of the Oct-2 cellular transcription factor. |journal=AIDS |volume=10 |issue= 12 |pages= 1323–9 |year= 1997 |pmid= 8902060 |doi=
*cite journal | author=Liu YZ, Latchman DS |title=The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat. |journal=Biochem. J. |volume=322 ( Pt 1) |issue= |pages= 155–8 |year= 1997 |pmid= 9078256 |doi=
*cite journal | author=Gorboulev V, Ulzheimer JC, Akhoundova A, "et al." |title=Cloning and characterization of two human polyspecific organic cation transporters. |journal=DNA Cell Biol. |volume=16 |issue= 7 |pages= 871–81 |year= 1997 |pmid= 9260930 |doi=
*cite journal | author=Koehler MR, Wissinger B, Gorboulev V, "et al." |title=The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26. |journal=Cytogenet. Cell Genet. |volume=79 |issue= 3-4 |pages= 198–200 |year= 1998 |pmid= 9605850 |doi=
*cite journal | author=Busch AE, Karbach U, Miska D, "et al." |title=Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. |journal=Mol. Pharmacol. |volume=54 |issue= 2 |pages= 342–52 |year= 1998 |pmid= 9687576 |doi=
*cite journal | author=Verhaagh S, Schweifer N, Barlow DP, Zwart R |title=Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. |journal=Genomics |volume=55 |issue= 2 |pages= 209–18 |year= 1999 |pmid= 9933568 |doi= 10.1006/geno.1998.5639
*cite journal | author=Gründemann D, Schömig E |title=Gene structures of the human non-neuronal monoamine transporters EMT and OCT2. |journal=Hum. Genet. |volume=106 |issue= 6 |pages= 627–35 |year= 2000 |pmid= 10942111 |doi=
*cite journal | author=Pietig G, Mehrens T, Hirsch JR, "et al." |title=Properties and regulation of organic cation transport in freshly isolated human proximal tubules. |journal=J. Biol. Chem. |volume=276 |issue= 36 |pages= 33741–6 |year= 2001 |pmid= 11447227 |doi= 10.1074/jbc.M104617200
*cite journal | author=Boehm J, He Y, Greiner A, "et al." |title=Regulation of BOB.1/OBF.1 stability by SIAH. |journal=EMBO J. |volume=20 |issue= 15 |pages= 4153–62 |year= 2001 |pmid= 11483518 |doi= 10.1093/emboj/20.15.4153
*cite journal | author=Barendt WM, Wright SH |title=The human organic cation transporter (hOCT2) recognizes the degree of substrate ionization. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22491–6 |year= 2002 |pmid= 11953440 |doi= 10.1074/jbc.M203114200
*cite journal | author=Urakami Y, Akazawa M, Saito H, "et al." |title=cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. |journal=J. Am. Soc. Nephrol. |volume=13 |issue= 7 |pages= 1703–10 |year= 2002 |pmid= 12089365 |doi=
*cite journal | author=Leabman MK, Huang CC, Kawamoto M, "et al." |title=Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. |journal=Pharmacogenetics |volume=12 |issue= 5 |pages= 395–405 |year= 2003 |pmid= 12142729 |doi=
*cite journal | author=Cetinkaya I, Ciarimboli G, Yalçinkaya G, "et al." |title=Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinases. |journal=Am. J. Physiol. Renal Physiol. |volume=284 |issue= 2 |pages= F293–302 |year= 2003 |pmid= 12388397 |doi= 10.1152/ajprenal.00251.2002
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gründemann D, Hahne C, Berkels R, Schömig E |title=Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2). |journal=J. Pharmacol. Exp. Ther. |volume=304 |issue= 2 |pages= 810–7 |year= 2003 |pmid= 12538837 |doi= 10.1124/jpet.102.044404
*cite journal | author=Bottalico B, Larsson I, Brodszki J, "et al." |title=Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies. |journal=Placenta |volume=25 |issue= 6 |pages= 518–29 |year= 2004 |pmid= 15135235 |doi= 10.1016/j.placenta.2003.10.017
*cite journal | author=Lips KS, Volk C, Schmitt BM, "et al." |title=Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium. |journal=Am. J. Respir. Cell Mol. Biol. |volume=33 |issue= 1 |pages= 79–88 |year= 2005 |pmid= 15817714 |doi= 10.1165/rcmb.2004-0363OC
*cite journal | author=Jiang W, Prokopenko O, Wong L, "et al." |title=IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity. |journal=Mol. Cell. Biol. |volume=25 |issue= 15 |pages= 6496–508 |year= 2005 |pmid= 16024787 |doi= 10.1128/MCB.25.15.6496-6508.2005

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