SLC27A2

Solute carrier family 27 (fatty acid transporter), member 2, also known as SLC27A2, is a human gene.cite web | title = Entrez Gene: SLC27A2 solute carrier family 27 (fatty acid transporter), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11001| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy.cite web | title = Entrez Gene: SLC27A2 solute carrier family 27 (fatty acid transporter), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11001| accessdate = ]

ee also

* Solute carrier family

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Uchiyama A, Aoyama T, Kamijo K, "et al." |title=Molecular cloning of cDNA encoding rat very long-chain acyl-CoA synthetase. |journal=J. Biol. Chem. |volume=271 |issue= 48 |pages= 30360–5 |year= 1997 |pmid= 8939997 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Hirsch D, Stahl A, Lodish HF |title=A family of fatty acid transporters conserved from mycobacterium to man. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 15 |pages= 8625–9 |year= 1998 |pmid= 9671728 |doi=
*cite journal | author=Wakui K, Aoyama T, Uchiyama A, "et al." |title=Assignment of human fatty-acid-coenzyme A ligase, very long-chain 1 gene (FACVL1) to human chromosome band 15q21.2 by fluorescence in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=81 |issue= 3-4 |pages= 292–3 |year= 1998 |pmid= 9730624 |doi=
*cite journal | author=Steinberg SJ, Wang SJ, Kim DG, "et al." |title=Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism. |journal=Biochem. Biophys. Res. Commun. |volume=257 |issue= 2 |pages= 615–21 |year= 1999 |pmid= 10198260 |doi= 10.1006/bbrc.1999.0510
*cite journal | author=Watkins PA, Pevsner J, Steinberg SJ |title=Human very long-chain acyl-CoA synthetase and two human homologs: initial characterization and relationship to fatty acid transport protein. |journal=Prostaglandins Leukot. Essent. Fatty Acids |volume=60 |issue= 5-6 |pages= 323–8 |year= 2000 |pmid= 10471116 |doi=
*cite journal | author=Steinberg SJ, Wang SJ, McGuinness MC, Watkins PA |title=Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein. |journal=Mol. Genet. Metab. |volume=68 |issue= 1 |pages= 32–42 |year= 1999 |pmid= 10479480 |doi= 10.1006/mgme.1999.2883
*cite journal | author=Mihalik SJ, Steinberg SJ, Pei Z, "et al." |title=Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling. |journal=J. Biol. Chem. |volume=277 |issue= 27 |pages= 24771–9 |year= 2002 |pmid= 11980911 |doi= 10.1074/jbc.M203295200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285

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