SLC22A8

SLC22A8

Solute carrier family 22 (organic anion transporter), member 8, also known as SLC22A8, is a human gene.cite web | title = Entrez Gene: SLC22A8 solute carrier family 22 (organic anion transporter), member 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9376| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney.cite web | title = Entrez Gene: SLC22A8 solute carrier family 22 (organic anion transporter), member 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9376| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Race JE, Grassl SM, Williams WJ, Holtzman EJ |title=Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). |journal=Biochem. Biophys. Res. Commun. |volume=255 |issue= 2 |pages= 508–14 |year= 1999 |pmid= 10049739 |doi= 10.1006/bbrc.1998.9978
*cite journal | author=Babu E, Takeda M, Narikawa S, "et al." |title=Human organic anion transporters mediate the transport of tetracycline. |journal=Jpn. J. Pharmacol. |volume=88 |issue= 1 |pages= 69–76 |year= 2002 |pmid= 11855680 |doi=
*cite journal | author=Motohashi H, Sakurai Y, Saito H, "et al." |title=Gene expression levels and immunolocalization of organic ion transporters in the human kidney. |journal=J. Am. Soc. Nephrol. |volume=13 |issue= 4 |pages= 866–74 |year= 2002 |pmid= 11912245 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Nishizato Y, Ieiri I, Suzuki H, "et al." |title=Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics. |journal=Clin. Pharmacol. Ther. |volume=73 |issue= 6 |pages= 554–65 |year= 2003 |pmid= 12811365 |doi= 10.1016/S0009-9236(03)00060-2
*cite journal | author=Bakhiya A, Bahn A, Burckhardt G, Wolff N |title=Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux. |journal=Cell. Physiol. Biochem. |volume=13 |issue= 5 |pages= 249–56 |year= 2004 |pmid= 14586168 |doi= 10.1159/000074539
*cite journal | author=Sakurai Y, Motohashi H, Ueo H, "et al." |title=Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases. |journal=Pharm. Res. |volume=21 |issue= 1 |pages= 61–7 |year= 2004 |pmid= 14984259 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Srimaroeng C, Chatsudthipong V, Aslamkhan AG, Pritchard JB |title=Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8). |journal=J. Pharmacol. Exp. Ther. |volume=313 |issue= 2 |pages= 621–8 |year= 2005 |pmid= 15644426 |doi= 10.1124/jpet.104.080366
*cite journal | author=Tahara H, Shono M, Kusuhara H, "et al." |title=Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney. |journal=Pharm. Res. |volume=22 |issue= 4 |pages= 647–60 |year= 2006 |pmid= 15846473 |doi= 10.1007/s11095-005-2503-0
*cite journal | author=Erdman AR, Mangravite LM, Urban TJ, "et al." |title=The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics. |journal=Am. J. Physiol. Renal Physiol. |volume=290 |issue= 4 |pages= F905–12 |year= 2006 |pmid= 16291576 |doi= 10.1152/ajprenal.00272.2005
*cite journal | author=Tahara H, Kusuhara H, Maeda K, "et al." |title=Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid. |journal=Drug Metab. Dispos. |volume=34 |issue= 5 |pages= 743–7 |year= 2006 |pmid= 16455804 |doi= 10.1124/dmd.105.008375
*cite journal | author=Bhatnagar V, Xu G, Hamilton BA, "et al." |title=Analyses of 5' regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3). |journal=J. Hum. Genet. |volume=51 |issue= 6 |pages= 575–80 |year= 2006 |pmid= 16648942 |doi= 10.1007/s10038-006-0398-1
*cite journal | author=Kikuchi R, Kusuhara H, Hattori N, "et al." |title=Regulation of the expression of human organic anion transporter 3 by hepatocyte nuclear factor 1alpha/beta and DNA methylation. |journal=Mol. Pharmacol. |volume=70 |issue= 3 |pages= 887–96 |year= 2006 |pmid= 16793932 |doi= 10.1124/mol.106.025494
*cite journal | author=Mizuno N, Takahashi T, Iwase Y, "et al." |title=Human organic anion transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) transport edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and its sulfate conjugate. |journal=Drug Metab. Dispos. |volume=35 |issue= 8 |pages= 1429–34 |year= 2007 |pmid= 17502342 |doi= 10.1124/dmd.106.013912
*cite journal | author=Matsumoto S, Yoshida K, Ishiguro N, "et al." |title=Involvement of rat and human organic anion transporter 3 in the renal tubular secretion of topotecan [(S)-9-dimethylaminomethyl-10-hydroxy-camptothecin hydrochloride] . |journal=J. Pharmacol. Exp. Ther. |volume=322 |issue= 3 |pages= 1246–52 |year= 2007 |pmid= 17556638 |doi= 10.1124/jpet.107.123323
*cite journal | author=Nozaki Y, Kusuhara H, Kondo T, "et al." |title=Species difference in the inhibitory effect of nonsteroidal anti-inflammatory drugs on the uptake of methotrexate by human kidney slices. |journal=J. Pharmacol. Exp. Ther. |volume=322 |issue= 3 |pages= 1162–70 |year= 2007 |pmid= 17578901 |doi= 10.1124/jpet.107.121491
*cite journal | author=VanWert AL, Bailey RM, Sweet DH |title=Organic anion transporter 3 (Oat3/"Slc22a8") knockout mice exhibit altered clearance and distribution of penicillin G. |journal=Am. J. Physiol. Renal Physiol. |volume=293 |issue= 4 |pages= F1332–41 |year= 2007 |pmid= 17686950 |doi= 10.1152/ajprenal.00319.2007
*cite journal | author=VanWert AL, Sweet DH |title=Impaired clearance of methotrexate in organic anion transporter 3 ("Slc22a8") knockout mice: A gender specific impact of reduced folates. |journal=Pharm. Res. |volume= [Epub ahead of print] |year= 2007 |pmid= 17660957 |doi= 10.1007/s11095-007-9407-0 |pages=453
*cite journal | author=Windass AS, Lowes S, Wang Y, Brown CD |title=The contribution of organic anion transporters OAT1 and OAT3 to the renal uptake of rosuvastatin. |journal=J. Pharmacol. Exp. Ther. |volume=322 |issue= 3 |pages= 1221–7 |year= 2007 |pmid= 17585018 |doi= 10.1124/jpet.107.125831

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