- SLC26A5
Solute carrier family 26, member 5 (prestin), also known as SLC26A5, is a human
gene .cite web | title = Entrez Gene: SLC26A5 solute carrier family 26, member 5 (prestin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=375611| accessdate = ]PBB_Summary
section_title =
summary_text = This gene is a member of the SLC26A/SulP transporter family. It encodes a protein that is specifically expressed in outer hair cells (OHCs) of the cochlea and is essential in auditory processing. Intracellular anions are thought to act as extrinsic voltage sensors, which bind to this protein and trigger the conformational changes required for rapid length changes in OHCs. Mutations in this gene have been associated with non-syndromic hearing loss. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.cite web | title = Entrez Gene: SLC26A5 solute carrier family 26, member 5 (prestin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=375611| accessdate = ]ee also
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Solute carrier family References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Markovich D |title=Physiological roles and regulation of mammalian sulfate transporters. |journal=Physiol. Rev. |volume=81 |issue= 4 |pages= 1499–533 |year= 2001 |pmid= 11581495 |doi=
*cite journal | author=Dallos P, Fakler B |title=Prestin, a new type of motor protein. |journal=Nat. Rev. Mol. Cell Biol. |volume=3 |issue= 2 |pages= 104–11 |year= 2002 |pmid= 11836512 |doi= 10.1038/nrm730
*cite journal | author=Dallos P, Zheng J, Cheatham MA |title=Prestin and the cochlear amplifier. |journal=J. Physiol. (Lond.) |volume=576 |issue= Pt 1 |pages= 37–42 |year= 2006 |pmid= 16873410 |doi= 10.1113/jphysiol.2006.114652
*cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=
*cite journal | author=Zheng J, Shen W, He DZ, "et al." |title=Prestin is the motor protein of cochlear outer hair cells. |journal=Nature |volume=405 |issue= 6783 |pages= 149–55 |year= 2000 |pmid= 10821263 |doi= 10.1038/35012009
*cite journal | author=Lohi H, Kujala M, Kerkelä E, "et al." |title=Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger. |journal=Genomics |volume=70 |issue= 1 |pages= 102–12 |year= 2001 |pmid= 11087667 |doi= 10.1006/geno.2000.6355
*cite journal | author=Oliver D, He DZ, Klöcker N, "et al." |title=Intracellular anions as the voltage sensor of prestin, the outer hair cell motor protein. |journal=Science |volume=292 |issue= 5525 |pages= 2340–3 |year= 2001 |pmid= 11423665 |doi= 10.1126/science.1060939
*cite journal | author=Weber T, Zimmermann U, Winter H, "et al." |title=Thyroid hormone is a critical determinant for the regulation of the cochlear motor protein prestin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 5 |pages= 2901–6 |year= 2002 |pmid= 11867734 |doi= 10.1073/pnas.052609899
*cite journal | author=Liberman MC, Gao J, He DZ, "et al." |title=Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier. |journal=Nature |volume=419 |issue= 6904 |pages= 300–4 |year= 2002 |pmid= 12239568 |doi= 10.1038/nature01059
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Liu XZ, Ouyang XM, Xia XJ, "et al." |title=Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss. |journal=Hum. Mol. Genet. |volume=12 |issue= 10 |pages= 1155–62 |year= 2004 |pmid= 12719379 |doi=
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Dong XX, Iwasa KH |title=Tension sensitivity of prestin: comparison with the membrane motor in outer hair cells. |journal=Biophys. J. |volume=86 |issue= 2 |pages= 1201–8 |year= 2004 |pmid= 14747354 |doi=
*cite journal | author=Matsuda K, Zheng J, Du GG, "et al." |title=N-linked glycosylation sites of the motor protein prestin: effects on membrane targeting and electrophysiological function. |journal=J. Neurochem. |volume=89 |issue= 4 |pages= 928–38 |year= 2004 |pmid= 15140192 |doi= 10.1111/j.1471-4159.2004.02377.x
*cite journal | author=Chambard JM, Ashmore JF |title=Regulation of the voltage-gated potassium channel KCNQ4 in the auditory pathway. |journal=Pflugers Arch. |volume=450 |issue= 1 |pages= 34–44 |year= 2005 |pmid= 15660259 |doi= 10.1007/s00424-004-1366-2
*cite journal | author=Rajagopalan L, Patel N, Madabushi S, "et al." |title=Essential helix interactions in the anion transporter domain of prestin revealed by evolutionary trace analysis. |journal=J. Neurosci. |volume=26 |issue= 49 |pages= 12727–34 |year= 2006 |pmid= 17151276 |doi= 10.1523/JNEUROSCI.2734-06.2006
*cite journal | author=Toth T, Deak L, Fazakas F, "et al." |title=A new mutation in the human pres gene and its effect on prestin function. |journal=Int. J. Mol. Med. |volume=20 |issue= 4 |pages= 545–50 |year= 2007 |pmid= 17786286 |doi=PBB_Controls
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