SLC1A2

Solute carrier family 1 (glial high affinity glutamate transporter), member 2, also known as SLC1A2, is a human gene.cite web | title = Entrez Gene: SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6506| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.cite web | title = Entrez Gene: SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6506| accessdate = ]

ee also

* Glutamate transporter
* Solute carrier family

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wang Z, Trillo-Pazos G, Kim SY, "et al." |title=Effects of human immunodeficiency virus type 1 on astrocyte gene expression and function: potential role in neuropathogenesis. |journal=J. Neurovirol. |volume=10 Suppl 1 |issue= |pages= 25–32 |year= 2004 |pmid= 14982736 |doi=
*cite journal | author=Arriza JL, Fairman WA, Wadiche JI, "et al." |title=Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. |journal=J. Neurosci. |volume=14 |issue= 9 |pages= 5559–69 |year= 1994 |pmid= 7521911 |doi=
*cite journal | author=Manfras BJ, Rudert WA, Trucco M, Boehm BO |title=Cloning and characterization of a glutamate transporter cDNA from human brain and pancreas. |journal=Biochim. Biophys. Acta |volume=1195 |issue= 1 |pages= 185–8 |year= 1994 |pmid= 7522567 |doi=
*cite journal | author=Li X, Francke U |title=Assignment of the gene SLC1A2 coding for the human glutamate transporter EAAT2 to human chromosome 11 bands p13-p12. |journal=Cytogenet. Cell Genet. |volume=71 |issue= 3 |pages= 212–3 |year= 1995 |pmid= 7587378 |doi=
*cite journal | author=Shashidharan P, Wittenberg I, Plaitakis A |title=Molecular cloning of human brain glutamate/aspartate transporter II. |journal=Biochim. Biophys. Acta |volume=1191 |issue= 2 |pages= 393–6 |year= 1994 |pmid= 8172925 |doi=
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Milton ID, Banner SJ, Ince PG, "et al." |title=Expression of the glial glutamate transporter EAAT2 in the human CNS: an immunohistochemical study. |journal=Brain Res. Mol. Brain Res. |volume=52 |issue= 1 |pages= 17–31 |year= 1998 |pmid= 9450673 |doi=
*cite journal | author=Shimamoto K, Lebrun B, Yasuda-Kamatani Y, "et al." |title=DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters. |journal=Mol. Pharmacol. |volume=53 |issue= 2 |pages= 195–201 |year= 1998 |pmid= 9463476 |doi=
*cite journal | author=Lin CL, Bristol LA, Jin L, "et al." |title=Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis. |journal=Neuron |volume=20 |issue= 3 |pages= 589–602 |year= 1998 |pmid= 9539131 |doi=
*cite journal | author=Aoki M, Lin CL, Rothstein JD, "et al." |title=Mutations in the glutamate transporter EAAT2 gene do not cause abnormal EAAT2 transcripts in amyotrophic lateral sclerosis. |journal=Ann. Neurol. |volume=43 |issue= 5 |pages= 645–53 |year= 1998 |pmid= 9585360 |doi= 10.1002/ana.410430514
*cite journal | author=Trotti D, Aoki M, Pasinelli P, "et al." |title=Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity. |journal=J. Biol. Chem. |volume=276 |issue= 1 |pages= 576–82 |year= 2001 |pmid= 11031254 |doi= 10.1074/jbc.M003779200
*cite journal | author=Münch C, Schwalenstöcker B, Hermann C, "et al." |title=Differential RNA cleavage and polyadenylation of the glutamate transporter EAAT2 in the human brain. |journal=Brain Res. Mol. Brain Res. |volume=80 |issue= 2 |pages= 244–51 |year= 2001 |pmid= 11038258 |doi=
*cite journal | author=Honig LS, Chambliss DD, Bigio EH, "et al." |title=Glutamate transporter EAAT2 splice variants occur not only in ALS, but also in AD and controls. |journal=Neurology |volume=55 |issue= 8 |pages= 1082–8 |year= 2000 |pmid= 11071482 |doi=
*cite journal | author=Flowers JM, Powell JF, Leigh PN, "et al." |title=Intron 7 retention and exon 9 skipping EAAT2 mRNA variants are not associated with amyotrophic lateral sclerosis. |journal=Ann. Neurol. |volume=49 |issue= 5 |pages= 643–9 |year= 2001 |pmid= 11357955 |doi=
*cite journal | author=Rimaniol AC, Mialocq P, Clayette P, "et al." |title=Role of glutamate transporters in the regulation of glutathione levels in human macrophages. |journal=Am. J. Physiol., Cell Physiol. |volume=281 |issue= 6 |pages= C1964–70 |year= 2001 |pmid= 11698255 |doi=
*cite journal | author=Tozaki H, Kanno T, Nomura T, "et al." |title=Role of glial glutamate transporters in the facilitatory action of FK960 on hippocampal neurotransmission. |journal=Brain Res. Mol. Brain Res. |volume=97 |issue= 1 |pages= 7–12 |year= 2002 |pmid= 11744157 |doi=
*cite journal | author=Palmada M, Kinne-Saffran E, Centelles JJ, Kinne RK |title=Benzodiazepines differently modulate EAAT1/GLAST and EAAT2/GLT1 glutamate transporters expressed in CHO cells. |journal=Neurochem. Int. |volume=40 |issue= 4 |pages= 321–6 |year= 2002 |pmid= 11792462 |doi=
*cite journal | author=Marie H, Billups D, Bedford FK, "et al." |title=The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba. |journal=Mol. Cell. Neurosci. |volume=19 |issue= 2 |pages= 152–64 |year= 2002 |pmid= 11860269 |doi= 10.1006/mcne.2001.1066
*cite journal | author=Reye P, Sullivan R, Fletcher EL, Pow DV |title=Distribution of two splice variants of the glutamate transporter GLT1 in the retinas of humans, monkeys, rabbits, rats, cats, and chickens. |journal=J. Comp. Neurol. |volume=445 |issue= 1 |pages= 1–12 |year= 2002 |pmid= 11891650 |doi=

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