ATP1A1

ATP1A1

ATPase, Na+/K+ transporting, alpha 1 polypeptide, also known as ATP1A1, is a human gene.cite web | title = Entrez Gene: ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=476| accessdate = ]

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+-ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lingrel JB, Orlowski J, Shull MM, Price EM |title=Molecular genetics of Na,K-ATPase. |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=38 |issue= |pages= 37–89 |year= 1990 |pmid= 2158121 |doi=
*cite journal | author=Dunbar LA, Caplan MJ |title=Ion pumps in polarized cells: sorting and regulation of the Na+, K+- and H+, K+-ATPases. |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 29617–20 |year= 2001 |pmid= 11404365 |doi= 10.1074/jbc.R100023200
*cite journal | author=Wangemann P |title=K+ cycling and the endocochlear potential. |journal=Hear. Res. |volume=165 |issue= 1-2 |pages= 1–9 |year= 2002 |pmid= 12031509 |doi=
*cite journal | author=Xie Z, Cai T |title=Na+-K+--ATPase-mediated signal transduction: from protein interaction to cellular function. |journal=Mol. Interv. |volume=3 |issue= 3 |pages= 157–68 |year= 2004 |pmid= 14993422 |doi= 10.1124/mi.3.3.157
*cite journal | author=Shull MM, Pugh DG, Lingrel JB |title=The human Na, K-ATPase alpha 1 gene: characterization of the 5'-flanking region and identification of a restriction fragment length polymorphism. |journal=Genomics |volume=6 |issue= 3 |pages= 451–60 |year= 1990 |pmid= 1970326 |doi=
*cite journal | author=Herrera VL, Ruiz-Opazo N |title=Alteration of alpha 1 Na+,K(+)-ATPase 86Rb+ influx by a single amino acid substitution. |journal=Science |volume=249 |issue= 4972 |pages= 1023–6 |year= 1990 |pmid= 1975705 |doi=
*cite journal | author=Kawakami K, Ohta T, Nojima H, Nagano K |title=Primary structure of the alpha-subunit of human Na,K-ATPase deduced from cDNA sequence. |journal=J. Biochem. |volume=100 |issue= 2 |pages= 389–97 |year= 1986 |pmid= 2430951 |doi=
*cite journal | author=Yang-Feng TL, Schneider JW, Lindgren V, "et al." |title=Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes. |journal=Genomics |volume=2 |issue= 2 |pages= 128–38 |year= 1988 |pmid= 2842249 |doi=
*cite journal | author=Sverdlov ED, Broude NE, Sverdlov VE, "et al." |title=Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism. |journal=FEBS Lett. |volume=221 |issue= 1 |pages= 129–33 |year= 1987 |pmid= 2887455 |doi=
*cite journal | author=Chehab FF, Kan YW, Law ML, "et al." |title=Human placental Na+,K+-ATPase alpha subunit: cDNA cloning, tissue expression, DNA polymorphism, and chromosomal localization. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 22 |pages= 7901–5 |year= 1987 |pmid= 2891135 |doi=
*cite journal | author=Ovchinnikov YuA , Monastyrskaya GS, Broude NE, "et al." |title=The family of human Na+,K+-ATPase genes. A partial nucleotide sequence related to the alpha-subunit. |journal=FEBS Lett. |volume=213 |issue= 1 |pages= 73–80 |year= 1987 |pmid= 3030810 |doi=
*cite journal | author=Shull MM, Lingrel JB |title=Multiple genes encode the human Na+,K+-ATPase catalytic subunit. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 12 |pages= 4039–43 |year= 1987 |pmid= 3035563 |doi=
*cite journal | author=Sverdlov ED, Monastyrskaya GS, Broude NE, "et al." |title=The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit. |journal=FEBS Lett. |volume=217 |issue= 2 |pages= 275–8 |year= 1987 |pmid= 3036582 |doi=
*cite journal | author=Ruiz A, Bhat SP, Bok D |title=Characterization and quantification of full-length and truncated Na,K-ATPase alpha 1 and beta 1 RNA transcripts expressed in human retinal pigment epithelium. |journal=Gene |volume=155 |issue= 2 |pages= 179–84 |year= 1995 |pmid= 7536695 |doi=
*cite journal | author=Hundal HS, Maxwell DL, Ahmed A, "et al." |title=Subcellular distribution and immunocytochemical localization of Na,K-ATPase subunit isoforms in human skeletal muscle. |journal=Mol. Membr. Biol. |volume=11 |issue= 4 |pages= 255–62 |year= 1995 |pmid= 7711835 |doi=
*cite journal | author=Feschenko MS, Sweadner KJ |title=Structural basis for species-specific differences in the phosphorylation of Na,K-ATPase by protein kinase C. |journal=J. Biol. Chem. |volume=270 |issue= 23 |pages= 14072–7 |year= 1995 |pmid= 7775468 |doi=
*cite journal | author=Ruiz-Opazo N, Barany F, Hirayama K, Herrera VL |title=Confirmation of mutant alpha 1 Na,K-ATPase gene and transcript in Dahl salt-sensitive/JR rats. |journal=Hypertension |volume=24 |issue= 3 |pages= 260–70 |year= 1994 |pmid= 8082931 |doi=
*cite journal | author=Zahler R, Gilmore-Hebert M, Baldwin JC, "et al." |title=Expression of alpha isoforms of the Na,K-ATPase in human heart. |journal=Biochim. Biophys. Acta |volume=1149 |issue= 2 |pages= 189–94 |year= 1993 |pmid= 8391840 |doi=
*cite journal | author=Wang J, Schwinger RH, Frank K, "et al." |title=Regional expression of sodium pump subunits isoforms and Na+-Ca++ exchanger in the human heart. |journal=J. Clin. Invest. |volume=98 |issue= 7 |pages= 1650–8 |year= 1996 |pmid= 8833915 |doi=

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